1-Amino-1-deoxy-D-fructose is an amino monosaccharide.1 It induces site-specific DNA damage at pyrimidine residues in cell-free assays. 1-Amino-1-deoxy-D-fructose moieties have been found as a component of fructosamines, glycated serum proteins that are elevated in patients with conditions such as diabetes.2,3
1.Nanjou, S., Fujii, S., Morita, J., et al.Sequence-specific alkali-labile lesions in DNA caused by ?-isoglucosamineBiochim. Biophys. Acta866(1)44-52(1986) 2.Danese, E., Montagnana, M., Novenne, A., et al.Advantages and pitfalls of fructosamine and glycated albumin in the diagnosis and treatment of diabetesJ. Diabetes Sci. Technol.9(2)169-176(2015) 3.Armbruster, D.A.Fructosamine: Structure, analysis, and clinical usefulnessClin. Chem.33(12)2153-2163(1987)