Phenylephrine HCl is a selective α1-adrenergic receptor agonist[1]. Phenylephrine HCl is commonly used to treat symptoms such as hypotension and nasal congestion[2]. Phenylephrine HCl can induce cardiac hypertrophy[3].
In vitro, phenylephrine HCl (0.1, 1, 10μM) treated cardiac fibroblasts for 48h stimulated cell proliferation in a dose-dependent manner, upregulated calcineurin (CaN) levels, and caused nuclear factor of activated T cells 3 (NFAT3) nuclear translocation[4].
In vivo, phenylephrine HCl (0.001-10μM) was injected into the alveolar cavity to treat rats with high tidal volume (HVT) mechanical ventilation-induced lung injury, which increased the alveolar fluid clearance (AFC) of rats and accelerated the absorption of pulmonary edema[5].
References:
[1] Bouchelouche K, Andersen L, Alvarez S, et al. Increased contractile response to phenylephrine in detrusor of patients with bladder outlet obstruction: effect of the α1A and α1D-adrenergic receptor antagonist tamsulosin[J]. The Journal of urology, 2005, 173(2): 657-661.
[2] Eccles R. Substitution of phenylephrine for pseudoephedrine as a nasal decongeststant. An illogical way to control methamphetamine abuse[J]. British journal of clinical pharmacology, 2007, 63(1): 10-14.
[3] Zheng J, Tian J, Wang S, et al. Stachydrine hydrochloride suppresses phenylephrine-induced pathological cardiac hypertrophy by inhibiting the calcineurin/nuclear factor of activated T-cell signalling pathway[J]. European Journal of Pharmacology, 2020, 883: 173386.
[4] Wang J, Wang Y, Zhang W, et al. Phenylephrine promotes cardiac fibroblast proliferation through calcineurin-NFAT pathway[J]. development, 2016.
[5] Li N, Gu X, Li W, et al. Effect of phenylephrine on alveolar fluid clearance in ventilator-induced lung injury[J]. Chinese Medical Sciences Journal, 2013, 28(1): 1-6.
Phenylephrine HCl（盐酸去氧肾上腺素）是一种选择性的α1-肾上腺素能受体激动剂[1]。Phenylephrine HCl常用于治疗低血压、鼻塞等症状[2]。Phenylephrine HCl可以诱导心脏肥大[3]。
在体外，Phenylephrine HCl（0.1, 1, 10μM）处理心脏成纤维细胞48h，以剂量依赖性方式刺激细胞增殖，上调了钙调磷酸酶（CaN）水平，引起了活化T细胞核因子3（NFAT3）核转位[4]。
在体内，Phenylephrine HCl（0.001-10μM）通过注入肺泡腔治疗高潮气量（HVT）机械通气诱导的肺损伤大鼠，可增加大鼠的肺泡液清除率（AFC）并加速肺水肿的吸收[5]。