Poly-L-lysine (M.W 70000~150000) is a polymer consists of numerous L-lysine with great biocompatibility [1]. Poly-L-lysine shows a wide range of antimicrobial activity and is stable at high temperatures and under both acidic and alkaline conditions[2]. The mechanism of the inhibitory effect of Poly-L-lysine on microbial growth is the electrostatic adsorption to the cell surface of microorganisms on the basis of the poly-cationic property [2]. Poly-L-lysine has effectively been used to adhere biological material such as human red blood cells, mouse leukemic cells, and marine dinoflagellates to glass coverslips[3]. Poly-L-lysine has been widely used as a coating material for porous biomass carrier particles to increase the density of immobilized Escherichia coli cells[4]. Poly-L-lysine is widely used in imaging identification and bio-silicification, not only as antimicrobial or antiviral drug carriers of proteins, and nucleic acids but also as adjuvants, modifiers, temples, or catalysts for certain drugs [5].
References:
[1] Stagi L, Sini M, Carboni D, et al. Modulating the poly-l-lysine structure through the control of the protonation–deprotonation state of l-lysine[J]. Scientific Reports, 2022, 12(1): 19719.
[2] Yoshida T, Nagasawa T. ε-Poly-l-lysine: microbial production, biodegradation and application potential[J]. Applied microbiology and biotechnology, 2003, 62(1): 21-26.
[3] Botes L, Price B, Waldron M, et al. A simple and rapid scanning electron microscope preparative technique for delicate “gymnodinioid” dinoflagellates[J]. Microscopy research and technique, 2002, 59(2): 128-130.
[4] Huang J, Yamaji H, Fukuda H. Immobilization of Escherichia coli cells using porous support particles coated with cationic polymers[J]. Journal of bioscience and bioengineering, 2007, 104(2): 98-103.
[5] Chen S, Huang S, Li Y, et al. Recent advances in epsilon-poly-L-lysine and L-lysine-based dendrimer synthesis, modification, and biomedical applications[J]. Frontiers in Chemistry, 2021, 9: 659304.
Poly-L-lysine (M.W 70000~150000)是一种由大量L-赖氨酸组成的聚合物，具有良好的生物相容性[1]。Poly-L-lysine表现出广谱抗菌活性，并且在高温、酸性和碱性条件下均能保持稳定[2]。Poly-L-lysine抑制微生物生长的机制是基于聚阳离子特性，通过静电吸附到微生物的细胞表面[2]。Poly-L-lysine已被有效地用于将生物材料（如人红细胞、小鼠白血病细胞和海洋甲藻）粘附到玻璃盖玻片上[3]。Poly-L-lysine已被广泛用作多孔生物质载体颗粒的涂层材料，以增加固定化大肠杆菌细胞的密度[4]。Poly-L-lysine广泛应用于成像识别和生物硅化领域，不仅作为蛋白质和核酸的抗菌或抗病毒药物载体，还作为某些药物的佐剂、修饰剂、模板或催化剂[5]。