GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC11547 structure
    GC11547MI-773 (SAR405838)
    CAS: 1303607-60-4
    纯度: >95.00% / >98.00%

    An inhibitor of MDM2-p53 protein-protein interactions

  • GC11551 structure
    GC11551Hydrocortisone
    CAS: 50-23-7
    纯度: >99.50% / >98.00%

    氢化可的松是一种由肾上腺和肾上腺外组织分泌的天然糖皮质激素，通过与其同源糖皮质激素受体 (GR) 结合，局部控制参与炎症、免疫反应、新陈代谢和能量稳态的基因的转录 。

  • GC11553 structure
    GC115532-cyano-Pyrimidine
    CAS: 14080-23-0
    纯度: >99.50%

    A cathepsin K inhibitor

  • GC11560 structure
    GC11560Resorcinolnaphthalein
    CAS: 41307-63-5
    纯度: >98.50%

    Activator of ACE2

  • GC11581 structure
    GC115812-Deoxyinosine
    CAS: 890-38-0
    纯度: >98.00%

    A nucleoside form of hypoxanthine

  • GC11594 structure
    GC11594RG7388
    CAS: 1229705-06-9
    纯度: >99.50%

    RG7388是一种具有口服活性的MDM2（IC 50 =6nM）拮抗剂，RG7388通过抑制MDM2-p53相互作用来激活p53通路。

  • GC11642 structure
    GC116422-Deoxyadenosine
    CAS: 958-09-8
    纯度: >98.00%

    2-Deoxyadenosine 是一种核苷腺苷衍生物，与双链 DNA 中的脱氧胸苷 (T) 配对。

  • GC11655 structure
    GC11655Moexipril HCl
    CAS: 82586-52-5
    纯度: >98.00%

    A prodrug form of moexiprilat

  • GC11669 structure
    GC11669Tamoxifen Citrate
    CAS: 54965-24-1
    纯度: >99.50%

    A selective estrogen receptor modulator

  • GC11672 structure
    GC11672Argatroban
    CAS: 74863-84-6

    A thrombin inhibitor

  • GC11720 structure
    GC1172017-AAG (KOS953)
    CAS: 75747-14-7
    纯度: >99.00% / >98.00%

    17-AAG（格尔德霉素）是一种天然的苯醌安沙霉素抗生素，是第一个确定的 Hsp90 抑制剂。

  • GC11764 structure
    GC11764MMP Inhibitor II
    CAS: 203915-59-7

    A broad-range inhibitor of MMPs

  • GC11784 structure
    GC11784LCZ696
    CAS: 936623-90-4
    纯度: >99.50%

    A dual angiotensin II receptor antagonist and neprilysin inhibitor

  • GC11786 structure
    GC11786Acetylcysteine
    CAS: 616-91-1
    纯度: >99.00%

    乙酰半胱氨酸是半胱氨酸的 N-乙酰基衍生物。

  • GC11804 structure
    GC118042-Guanidinoethylmercaptosuccinic Acid
    CAS: 77482-44-1

    A carboxypeptidase inhibitor

  • GC11828 structure
    GC11828N-carbamoyl-DL-aspartic acid
    CAS: 923-37-5

    An intermediate in pyrimidine biosynthesis

  • GC11843 structure
    GC11843Azaguanine-8
    CAS: 134-58-7
    纯度: >98.00%

    Azaguanine-8 是一种嘌呤类似物，具有抗肿瘤活性。 Azaguanine-8 起抗代谢物的作用，很容易与核糖核酸结合，干扰正常的生物合成途径，从而抑制细胞生长。

  • GC11847 structure
    GC11847(Z-Ala-Ala-Ala-Ala)2Rh110
    CAS: 149695-85-2
    纯度: >95.00%

    (Z-Ala-Ala-Ala-Ala)2Rh110是一种灵敏的荧光弹性蛋白酶底物，无色且不发荧光的 (Z-Ala-Ala-Ala-Ala)2Rh110被弹性蛋白酶选择性裂解，产生强荧光化合物罗丹明110，罗丹明110的激发/发射波长为485nm/525nm。

  • GC11865 structure
    GC11865UK-5099
    CAS: 56396-35-1
    纯度: >99.50%

    UK-5099是一种线粒体丙酮酸载体（MPC）抑制剂，抑制丙酮酸依赖性O 2 消耗的IC 50 值为50nM。

  • GC11869 structure
    GC11869SZL P1-41
    CAS: 222716-34-9
    纯度: >98.00%

    SZL P1-41是一种特异性S期激酶相关蛋白2（Skp2）抑制剂。

  • GC11872 structure
    GC11872Creatinine
    CAS: 60-27-5
    纯度: >99.50%

    The end product of the creatine-creatine phosphate energy shuttle

  • GC11894 structure
    GC11894BMS 309403
    CAS: 300657-03-8
    纯度: >99.50% / >98.00%

    BMS 309403是一种强效、具有口服活性且选择性的adipocyte fatty acid binding protein (FABP4)抑制剂，IC 50 值为0.71μM。

  • GC11930 structure
    GC11930KNK437
    CAS: 218924-25-5
    纯度: >98.00%

    Prevents the synthesis of inducible heat shock proteins

  • GC11941 structure
    GC11941Flavin adenine dinucleotide disodium
    CAS: 84366-81-4
    纯度: >98.00% / >95.00% / >99.00%

    Flavin adenine dinucleotide disodium（黄素腺嘌呤二核苷酸，FAD）是一种重要的氧化还原辅因子，广泛参与细胞的能量代谢和电子传递过程。