GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC11969 structure
    GC11969Adenosine-5'-diphosphate
    CAS: 58-64-0
    纯度: >98.00% / >99.50%

    Adenosine-5'-diphosphate是 P2Y1、P2Y12、P2Y13 等嘌呤能 P2Y 受体的天然激动剂，可直接结合并触发下游信号级联。

  • GC11973 structure
    GC11973HSP990 (NVP-HSP990)
    CAS: 934343-74-5
    纯度: >98.00%

    An Hsp90 inhibitor

  • GC11981 structure
    GC11981Neutrophil Elastase Inhibitor
    CAS: 1448314-31-5
    纯度: >95.00%

    A selective inhibitor of neutrophil elastase

  • GC11988 structure
    GC1198815-acetoxy Scirpenol
    CAS: 2623-22-5

    A trichothecene mycotoxin

  • GC11989 structure
    GC11989Nortriptyline (hydrochloride)
    CAS: 894-71-3
    纯度: >99.50%

    A tricyclic antidepressant

  • GC12040 structure
    GC12040L-Kynurenine
    CAS: 2922-83-0
    纯度: >98.00%

    L-Kynurenine是L-色氨酸的代谢物，也是一种芳香烃受体 (aryl hydrocarbon receptor; AhR) 激动剂。

  • GC12088 structure
    GC12088BAY-678
    CAS: 675103-36-3
    纯度: >99.00%

    A selective, cell permeable inhibitor of human neutrophil elastase

  • GC12090 structure
    GC12090Nonactin
    CAS: 6833-84-7
    纯度: >95.00%

    Nonactin是一种大环四内酯类抗生素和线粒体氧化磷酸化解偶联剂。

  • GC12096 structure
    GC12096Semagacestat (LY450139)
    CAS: 425386-60-3
    纯度: >99.50%

    A pan γ-secretase inhibitor

  • GC12117 structure
    GC12117JNJ-26854165 (Serdemetan)
    CAS: 881202-45-5
    纯度: >99.00%

    An antagonist of MDM2 action

  • GC12123 structure
    GC12123sn-Glycero-3-phosphocholine
    CAS: 28319-77-9
    纯度: >98.00%

    A nootropic phospholipid

  • GC12148 structure
    GC12148Ethinyl Estradiol
    CAS: 57-63-6
    纯度: >99.50%

    A 17β-estradiol analog

  • GC12175 structure
    GC12175MLN4924 HCl salt
    CAS: 1160295-21-5
    纯度: >98.00%

    A selective inhibitor of NEDD8-activating enzyme

  • GC12182 structure
    GC12182Estriol
    CAS: 50-27-1
    纯度: >99.00%

    Estriol是雌激素受体（ERα和ERβ）的激动剂和G蛋白偶联受体30（GPR30）的拮抗剂。

  • GC12203 structure
    GC12203L-Glutathione Reduced
    CAS: 70-18-8
    纯度: >99.00% / >97.00%

    Nucleophilic co-substrate to glutathione transferases and electron donor to glutathione peroxidases

  • GC12223 structure
    GC12223Z-Asp-CH2-DCB
    CAS: 153088-73-4
    纯度: >99.00%

    A pan-caspase inhibitor

  • GC12235 structure
    GC12235Sitagliptin (phosphate)
    CAS: 654671-78-0
    纯度: >98.00%

    A DPP-4 inhibitor

  • GC12256 structure
    GC12256D-Mannitol
    CAS: 69-65-8
    纯度: >99.00%

    An Analytical Reference Standard

  • GC12287 structure
    GC12287Z-DEVD-FMK
    CAS: 210344-95-9
    纯度: >95.00% / >98.00% / >98.50%

    Z-DEVD-FMK是一种特异性的不可逆的半胱氨酸-天冬氨酸蛋白酶3（caspase-3）抑制剂，IC 50 为18μM。

  • GC12301 structure
    GC12301Mizoribine
    CAS: 50924-49-7
    纯度: >98.50%

    An imidazole nucleoside with immunosuppressive properties

  • GC12327 structure
    GC12327Corticosterone
    CAS: 50-22-6
    纯度: >99.50% / >97.00% / >98.00% / >99.00%

    Corticosterone (17 deoxycortisol) 是一种具有口服活性的糖皮质激素，由肾上腺皮质产生，对调节边缘系统（包括海马、前额叶皮层和杏仁核）的神经元功能具有重要作用。

  • GC12339 structure
    GC12339Ivermectin
    CAS: 70288-86-7
    纯度: >98.00%

    Ivermectin是一种大环内酯类内外抗寄生虫药，对体内和体外寄生虫均有活性。

  • GC12344 structure
    GC12344TAPI-1
    CAS: 163847-77-6

    TAPI-1是一种TACE（肿瘤坏死因子-α转化酶）抑制剂，通过抑制TACE的蛋白水解酶活性，阻断其介导的细胞膜蛋白（两性调节蛋白（AREG））的胞外域脱落过程。

  • GC12349 structure
    GC12349Deoxycorticosterone acetate
    CAS: 56-47-3
    纯度: >98.00%

    A corticosteroid