GlpBio

Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

  • GC12360 structure
    GC12360UAMC 00039 dihydrochloride
    CAS: 697797-51-6
    纯度: >99.50%

    A potent DPP-2 inhibitor

  • GC12368 structure
    GC12368Quinapril HCl
    CAS: 82586-55-8
    纯度: >99.00%

    A prodrug form of quinaprilat

  • GC12387 structure
    GC12387Tiplaxtinin(PAI-039)
    CAS: 393105-53-8
    纯度: >98.00%

    Tiplaxtinin(PAI-039)是一种口服生物利用的尿激酶型纤溶酶原激活物抑制剂-1（PAI-1）拮抗剂，IC 50 值为2.7μM。

  • GC12391 structure
    GC12391Xanthohumol
    CAS: 6754-58-1
    纯度: >99.50% / >98.00%

    Xanthohumol是啤酒花中主要的异戊烯基黄酮类化合物，能够抑制二酰甘油酰基转移酶（DGAT），IC 50 值为50.3μM。

  • GC12395 structure
    GC12395(D)-(+)-Neopterin
    CAS: 2009-64-5
    纯度: >98.00%

    A biochemical tool to screen for immune disorders

  • GC12408 structure
    GC12408Progesterone
    CAS: 57-83-0
    纯度: >98.00%

    An endogenous hormone and hormone precursor

  • GC12411 structure
    GC12411RHC 80267
    CAS: 83654-05-1
    纯度: >99.50%

    RHC 80267是一种有效的、选择性二酰基甘油脂酶（DAGL）抑制剂，RHC 80267还能够抑制胆碱酯酶活性（IC₅₀=4μM），可抑制环氧化酶（COX）活性和磷脂酰胆碱的水解。

  • GC12431 structure
    GC12431RSL3
    CAS: 1219810-16-8
    纯度: >98.00%

    RSL3被认为是一种强效的诱导铁死亡剂，其作用依赖于GPX4的活性。

  • GC12444 structure
    GC12444Clemizole
    CAS: 442-52-4

    An antihistamine and TRPC5 channel blocker

  • GC12479 structure
    GC12479Calpain Inhibitor XII
    CAS: 181769-57-3

    A selective inhibitor of calpain I

  • GC12508 structure
    GC12508Nutlin-3b
    CAS: 675576-97-3
    纯度: >98.00%

    The less active enantiomer of (–)-nutlin-3

  • GC12518 structure
    GC12518L-Dihydroorotic acid
    CAS: 5988-19-2
    纯度: >98.00%

    L-二氢乳清酸可以通过二氢乳清酶可逆地水解产生无环L-脲基琥珀酸。

  • GC12527 structure
    GC12527MG-101 (Calpain Inhibitor I, ALLN)
    CAS: 110044-82-1
    纯度: >98.00%

    MG-101 (Calpain Inhibitor I, ALLN)是半胱氨酸蛋白酶 的抑制剂，抑制钙蛋白酶I，钙蛋白酶II，组织蛋白酶B和组织蛋白酶L，其Ki值分别为90，220，150和500pM。

  • GC12545 structure
    GC125452-HBA
    CAS: 131359-24-5
    纯度: >98.00%

    An indirect inhibitor of Keap1-Nrf2 interactions

  • GC12604 structure
    GC12604Fumonisin B1
    CAS: 116355-83-0
    纯度: >98.00% / >95.00%

    A mycotoxin

  • GC12647 structure
    GC12647NVP-CGM097
    CAS: 1313363-54-0
    纯度: >98.50%

    An inhibitor of the MDM2-p53 interaction

  • GC12661 structure
    GC12661Indirubin-3'-oxime
    CAS: 160807-49-8
    纯度: >99.00%

    Inhibitor of GSK3β and cyclin-dependent kinases

  • GC12664 structure
    GC12664Urea
    CAS: 57-13-6
    纯度: >98.00% / >99.00%

    尿素是一种强大的蛋白质变性剂，通过直接和间接机制。

  • GC12685 structure
    GC12685Ercalcitriol
    CAS: 60133-18-8
    纯度: >99.00%

    A potent agonist of the vitamin D receptor

  • GC12713 structure
    GC127135-Aminovaleric acid hydrochloride
    CAS: 660-88-8
    纯度: >98.00%

    5-氨基戊酸盐酸盐被认为是 γ-氨基丁酸 (GABA) 的亚甲基同系物，并作为弱 GABA 激动剂发挥作用。

  • GC12715 structure
    GC12715Synephrine HCl
    CAS: 5985-28-4
    纯度: >99.50%

    An alkaloid

  • GC12732 structure
    GC12732TNP-470
    CAS: 129298-91-5
    纯度: >99.50%

    An inhibitor of angiogenesis

  • GC12751 structure
    GC12751Balicatib
    CAS: 354813-19-7
    纯度: >98.00%

    A cathepsin K inhibitor

  • GC12809 structure
    GC12809Itaconic acid
    CAS: 97-65-4
    纯度: >98.00%

    Itaconic acid是一种不饱和二羧酸，可由原核生物和真菌合成，也可在哺乳动物巨噬细胞感染过程中由乌头酸脱羧酶1（ACOD1，也称为IRG1）产生和分泌。