Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC12974Medroxyprogesterone acetateCAS: 71-58-9纯度: >99.50%
Medroxyprogesterone acetate（MPA）是一种人工合成的孕激素。
- GC13216trans-trans Muconic acidCAS: 3588-17-8纯度: >98.00%
trans-trans Muconic acid 是一种苯的尿代谢物，已被用作人体接触苯的生物标志物。
- GC13228Phosphocreatine disodium saltCAS: 922-32-7纯度: >98.00% / >97.00%
Phosphocreatine disodium salt是肌肉和大脑等高能量波动需求组织中的重要能量储备物质。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC12829 | 5-hydroxy Tryptophol | 154-02-9 | >98.00% | |
A metabolite of tryptophan | ||||
| GC12838 | Edaravone | 89-25-8 | >99.50% | |
Edaravone是一种经典的自由基清除剂，作为有机小分子可穿越血脑屏障，为脑细胞提供保护。 | ||||
| GC12850 | 2-Deoxy-D-ribose | 533-67-5 | - | |
A reducing sugar | ||||
| GC12859 | Cilazapril | 88768-40-5 | - | |
A prodrug form of cilazaprilat | ||||
| GC12917 | Acetaminophen | 103-90-2 | >99.00% | |
An analgesic and antipyretic compound | ||||
| GC12920 | Pregnenolone | 145-13-1 | >98.00% | |
A natural steroid hormone | ||||
| GC12945 | Atazanavir | 198904-31-3 | - | |
An inhibitor of HIV-1 protease | ||||
| GC12964 | 2-3-Dihydroxybenzoic acid | 303-38-8 | - | |
2-3-二羟基苯甲酸是一种在血浆中发现的正常人体苯甲酸代谢物，在服用阿司匹林后水平会升高。 | ||||
| GC12974 | Medroxyprogesterone acetate | 71-58-9 | >99.50% | |
Medroxyprogesterone acetate（MPA）是一种人工合成的孕激素。 | ||||
| GC13005 | MMP-2 Inhibitor II | 869577-51-5 | - | |
A selective MMP-2 inhibitor | ||||
| GC13019 | RG7112 | 939981-39-2 | >99.50% | |
An inhibitor of the MDM2-p53 interaction | ||||
| GC13072 | Epiandrosterone | 481-29-8 | >98.00% | |
An Analytical Reference Standard | ||||
| GC13077 | RETF-4NA | 1160928-63-1 | - | |
RETF-4NA 是一种糜酶特异性底物，当游离或与 α2M 结合时，它是一种敏感和选择性的糜酶底物。 | ||||
| GC13078 | Imidapril HCl | 89396-94-1 | >99.50% | |
A prodrug form of imidaprilat | ||||
| GC13084 | Ketoisovaleric acid | 759-05-7 | >98.00% | |
Ketoisovaleric acid（KIV）是亮氨酸和缬氨酸合成的前体。 | ||||
| GC13130 | Apixaban | 503612-47-3 | >99.50% | |
An inhibitor of Factor Xa | ||||
| GC13147 | AG-221 (Enasidenib) | 1446502-11-9 | >99.50% | |
An inhibitor of mutant IDH2 | ||||
| GC13161 | Escitalopram | 128196-01-0 | - | |
Escitalopram是一种高选择性的5-羟色胺再摄取抑制剂（K i =0.89nM）。 | ||||
| GC13172 | Adenosine 5-monophosphate | 61-19-8 | >99.00% | |
5-单磷酸腺苷是调节能量稳态和信号转导的关键细胞代谢物。 | ||||
| GC13206 | Nicotinic Acid | 59-67-6 | >99.50% | |
烟酸（维生素 B3）是一种具有口服活性的水溶性维生素 B3，是人体必需的营养素。 | ||||
| GC13216 | trans-trans Muconic acid | 3588-17-8 | >98.00% | |
trans-trans Muconic acid 是一种苯的尿代谢物，已被用作人体接触苯的生物标志物。 | ||||
| GC13228 | Phosphocreatine disodium salt | 922-32-7 | >98.00% / >97.00% | |
Phosphocreatine disodium salt是肌肉和大脑等高能量波动需求组织中的重要能量储备物质。 | ||||
| GC13293 | LP533401 hcl | 1040526-12-2 | >98.50% | |
An inhibitor of gut-derived serotonin biosynthesis | ||||
| GC13307 | PU-WS13 | 1454619-14-7 | >98.00% | |
PU-WS13是一种嘌呤支架类Grp94特异性热休克蛋白90（Hsp90）抑制剂。 | ||||