Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC13392Flavin adenine dinucleotideCAS: 146-14-5纯度: >98.00% / >97.00%
Flavin adenine dinucleotide（黄素腺嘌呤二核苷酸，FAD）是一种重要的氧化还原辅因子，广泛参与细胞的能量代谢和电子传递过程。
- GC13441CyclopamineCAS: 4449-51-8纯度: >99.50%
Cyclopamine是一种天然存在的Hedgehog (Hh)特异性小分子信号甾体生物碱抑制剂，对肿瘤生长具有深远的抑制作用，在人乳腺癌细胞中具有显著的抗侵袭、抗增殖和抗雌激素活性。
- GC13464GSK 2837808ACAS: 1445879-21-9纯度: >99.00%
GSK2837808A 是一种选择性的 LDHA (lactate dehydrogenase A) 的抑制剂,对hLDHA和hLDHB的IC50分别为2.6 nM和43 nM.GSK2837808A(10 µM;24-72h)通过促进有氧糖酵解、增殖、细胞周期和细胞凋亡抵抗,阻断了着丝粒蛋白N (CENP-N)过表达对鼻咽癌细胞的影响。
- GC13531Deoxyadenosine 5-triphosphateCAS: 1927-31-7纯度: >98.00%
Deoxyadenosine 5-triphosphate是一种由一个腺嘌呤碱基、一个脱氧核糖和三个磷酸基团组成的脱氧核苷酸三磷酸。
- GC13670MethylmalonateCAS: 516-05-2纯度: >98.00%
A dicarboxylic acid and byproduct of propionate catabolism
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC13312 | HZ-1157 | 1009734-33-1 | >98.50% | |
An HCV NS3/4A protease and Dengue virus inhibitor | ||||
| GC13363 | Ursodiol | 128-13-2 | >98.00% | |
Ursodiol（UDCA）是一种微生物通过初级胆汁酸鹅去氧胆酸（CDCA）的7α/β 异构化转化而来的次级胆汁酸。Ursodiol可用于多种肝脏疾病和胃肠道疾病的研究。 | ||||
| GC13377 | 3-hydroxy Anthranilic Acid | 548-93-6 | >95.00% | |
A tryptophan metabolite | ||||
| GC13392 | Flavin adenine dinucleotide | 146-14-5 | >98.00% / >97.00% | |
Flavin adenine dinucleotide（黄素腺嘌呤二核苷酸，FAD）是一种重要的氧化还原辅因子，广泛参与细胞的能量代谢和电子传递过程。 | ||||
| GC13421 | UCF 101 | 313649-08-0 | >98.00% | |
An Omi/HtrA2 protease inhibitor | ||||
| GC13432 | Adenine | 73-24-5 | >99.50% / >98.50% | |
腺嘌呤（6-氨基嘌呤）是一种嘌呤，是DNA核酸中的四种核碱基之一。腺嘌呤是DNA和RNA的化学成分。腺嘌呤还在涉及细胞呼吸、ATP 和辅因子（NAD 和 FAD）的形式以及蛋白质合成的生物化学中发挥重要作用。 | ||||
| GC13434 | CP-640186 | 591778-68-6 | >98.50% | |
An ACC inhibitor | ||||
| GC13441 | Cyclopamine | 4449-51-8 | >99.50% | |
Cyclopamine是一种天然存在的Hedgehog (Hh)特异性小分子信号甾体生物碱抑制剂，对肿瘤生长具有深远的抑制作用，在人乳腺癌细胞中具有显著的抗侵袭、抗增殖和抗雌激素活性。 | ||||
| GC13450 | PD 145305 | 90536-15-5 | - | |
An inactive analog of PD 150606 | ||||
| GC13454 | L-Leucine 4-methoxy-β-naphthylamide (hydrochloride) | 4467-68-9 | - | |
An aminopeptidase substrate | ||||
| GC13456 | Doxycycline hyclate | 24390-14-5 | >98.00% | |
Doxycycline hyclate是四环素的衍生物，具有抗炎和抗菌活性。 | ||||
| GC13464 | GSK 2837808A | 1445879-21-9 | >99.00% | |
GSK2837808A 是一种选择性的 LDHA (lactate dehydrogenase A) 的抑制剂,对hLDHA和hLDHB的IC50分别为2.6 nM和43 nM.GSK2837808A(10 µM;24-72h)通过促进有氧糖酵解、增殖、细胞周期和细胞凋亡抵抗,阻断了着丝粒蛋白N (CENP-N)过表达对鼻咽癌细胞的影响。 | ||||
| GC13502 | Cysteamine HCl | 156-57-0 | >98.00% | |
A radioprotective aminothiol | ||||
| GC13531 | Deoxyadenosine 5-triphosphate | 1927-31-7 | >98.00% | |
Deoxyadenosine 5-triphosphate是一种由一个腺嘌呤碱基、一个脱氧核糖和三个磷酸基团组成的脱氧核苷酸三磷酸。 | ||||
| GC13556 | VER-49009 | 558640-51-0 | >99.00% | |
An Hsp90 inhibitor | ||||
| GC13571 | 2-Deoxyuridine | 951-78-0 | >98.00% | |
A pyrimidine nucleoside | ||||
| GC13590 | SJ 172550 | 431979-47-4 | >98.00% | |
A small molecule inhibitor of MDMX | ||||
| GC13621 | Hexylresorcinol | 136-77-6 | >98.00% | |
An alkylresorcinol | ||||
| GC13670 | Methylmalonate | 516-05-2 | >98.00% | |
A dicarboxylic acid and byproduct of propionate catabolism | ||||
| GC13726 | TRO 19622 | 22033-87-0 | >99.50% | |
A mitochondrial-targeted neuroprotective agent | ||||
| GC13729 | Cytidine | 65-46-3 | >99.50% / >98.00% | |
A pyrimidine nucleoside | ||||
| GC13742 | Uridine | 58-96-8 | >99.50% | |
Uridine是一种核苷，包含尿嘧啶，通过β-N1-糖苷键与核糖环连接。 | ||||
| GC13749 | O-Phosphorylethanolamine | 1071-23-4 | >98.00% | |
A phospholipid metabolite | ||||
| GC13804 | Ercalcidiol | 21343-40-8 | >99.00% | |
Ercalcidiol是一种可反映体内维生素D营养水平的维生素D 2 代谢物。 | ||||