Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC13852CalcitriolCAS: 32222-06-3纯度: >99.00% / >99.50%
骨化三醇作为类固醇激素维生素 D 的最具生物活性的代谢产物，抑制骨化三醇会导致抗癌药物的作用降低。
- GC1388725(R)-27-hydroxy CholesterolCAS: 20380-11-4纯度: >98.00%
25(R)-27-hydroxy Cholesterol是肝脏X受体（LXR）α和LXRβ的激动剂，EC 50 值分别为0.085μM和0.071μM。
- GC13890(±)-Palmitoylcarnitine chlorideCAS: 6865-14-1
A long-chain acylcarnitine with intracellular and extracellular roles
- GC13967Tosyllysine Chloromethyl Ketone (hydrochloride)CAS: 4272-74-6纯度: >98.00%
A non-selective proteinase inhibitor
- GC14049(-)-Epigallocatechin gallate (EGCG)CAS: 989-51-5纯度: >99.50% / >99.00% / >98.00%
(-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。
- GC14057GSK1349572 sodiuM saltCAS: 1051375-19-9纯度: >99.00%
GSK1349572 sodiuM salt (S/GSK1349572 sodium) 是一种高效的口服生物可利用的 HIV 整合酶链转移抑制剂，对 HIV-1 整合酶催化的链转移的 IC50 为 2.7 nM。
- GC14064p-ChlorophenylalanineCAS: 7424-00-2纯度: >98.00% / >98.50% / >99.50%
An inhibitor of tryptophan hydroxylase
- GC14331Folinic acidCAS: 58-05-9纯度: >99.50%
亚叶酸 (Leucovorin) 是一种生物叶酸，通常与甲氨蝶呤 (MTX) 一起作为救援剂给药，以降低 MTX 诱导的毒性。
- GC14411ApoptozoleCAS: 1054543-47-3纯度: >99.50%
Apoptozole是一种小分子抑制剂，可靶向HSC70和HSP72，K D 值分别为210nM和140nM。
- GC144337α,25-dihydroxy CholesterolCAS: 64907-22-8纯度: ≥95.00% / >99.50%
A potent and selective agonist of GPR183
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC13852 | Calcitriol | 32222-06-3 | >99.00% / >99.50% | |
骨化三醇作为类固醇激素维生素 D 的最具生物活性的代谢产物，抑制骨化三醇会导致抗癌药物的作用降低。 | ||||
| GC13877 | 1,2-Dipalmitoyl-sn-glycerol | 30334-71-5 | >95.00% / >97.00% | |
A diacylglycerol | ||||
| GC13887 | 25(R)-27-hydroxy Cholesterol | 20380-11-4 | >98.00% | |
25(R)-27-hydroxy Cholesterol是肝脏X受体（LXR）α和LXRβ的激动剂，EC 50 值分别为0.085μM和0.071μM。 | ||||
| GC13890 | (±)-Palmitoylcarnitine chloride | 6865-14-1 | - | |
A long-chain acylcarnitine with intracellular and extracellular roles | ||||
| GC13949 | Alogliptin Benzoate | 850649-62-6 | >99.50% | |
A DPP-4 inhibitor | ||||
| GC13955 | Enoxolone | 471-53-4 | >99.50% / >98.00% | |
An anti-inflammatory and immunomodulatory compound | ||||
| GC13958 | BPTES | 314045-39-1 | >98.00% | |
BPTES是一种高效且选择性的肾型谷氨酰胺酶（GLS）变构抑制剂，已被用作分子探针以确定GLS抑制的治疗潜力。 | ||||
| GC13967 | Tosyllysine Chloromethyl Ketone (hydrochloride) | 4272-74-6 | >98.00% | |
A non-selective proteinase inhibitor | ||||
| GC14042 | Oleamide | 301-02-0 | >65.00% | |
An amide of oleic acid and agonist of CB 1 receptors | ||||
| GC14049 | (-)-Epigallocatechin gallate (EGCG) | 989-51-5 | >99.50% / >99.00% / >98.00% | |
(-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。 | ||||
| GC14055 | Vanillin | 121-33-5 | >99.50% | |
An Analytical Reference Standard | ||||
| GC14057 | GSK1349572 sodiuM salt | 1051375-19-9 | >99.00% | |
GSK1349572 sodiuM salt (S/GSK1349572 sodium) 是一种高效的口服生物可利用的 HIV 整合酶链转移抑制剂，对 HIV-1 整合酶催化的链转移的 IC50 为 2.7 nM。 | ||||
| GC14064 | p-Chlorophenylalanine | 7424-00-2 | >98.00% / >98.50% / >99.50% | |
An inhibitor of tryptophan hydroxylase | ||||
| GC14098 | Menadione | 58-27-5 | >98.00% | |
A provitamin | ||||
| GC14106 | Adenosine | 58-61-7 | >99.50% / >99.00% | |
Adenosine是一种内源性神经调节物质，包含腺嘌呤，通过β-N9-糖苷键与核糖分子（呋喃核糖）部分连接。 | ||||
| GC14142 | Acetylcholine Chloride | 60-31-1 | >99.00% / >98.00% | |
A neurotransmitter | ||||
| GC14188 | Z-YVAD-FMK | 210344-97-1 | >98.00% | |
Z-YVAD-FMK是一种可穿透细胞的不可逆caspase-1和caspase-4 抑制剂。 | ||||
| GC14203 | Citric acid | 77-92-9 | >99.00% / >98.00% | |
柠檬酸是一种天然防腐剂和食品酸味增强剂。 | ||||
| GC14301 | Spaglumic acid | 3106-85-2 | >98.00% | |
A peptide neurotransmitter | ||||
| GC14328 | FCCP | 370-86-5 | >99.50% / >98.00% | |
FCCP是一种质子载体（H+离子载体），也是一种强磷酸化解偶联剂，促进质膜和线粒体膜的去极化。 | ||||
| GC14331 | Folinic acid | 58-05-9 | >99.50% | |
亚叶酸 (Leucovorin) 是一种生物叶酸，通常与甲氨蝶呤 (MTX) 一起作为救援剂给药，以降低 MTX 诱导的毒性。 | ||||
| GC14385 | Estrone | 53-16-7 | >98.00% | |
Estrone是三种主要的内源性雌激素之一，其他是雌二醇和雌三醇。 | ||||
| GC14411 | Apoptozole | 1054543-47-3 | >99.50% | |
Apoptozole是一种小分子抑制剂，可靶向HSC70和HSP72，K D 值分别为210nM和140nM。 | ||||
| GC14433 | 7α,25-dihydroxy Cholesterol | 64907-22-8 | ≥95.00% / >99.50% | |
A potent and selective agonist of GPR183 | ||||