Proteases

Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

研究方向

Proteases 相关产品(4079)

GC14435 Zileuton sodium
CAS: 118569-21-4
A reversible inhibitor of 5-lipoxygenase
GC14441 SW033291
CAS: 459147-39-8
纯度: >98.50% / >99.00% / >98.00%
SW033291是15-羟基前列腺素脱氢酶（15-PGDH）的小分子抑制剂，15-PGDH是一种催化PGE2氧化和失活的酶。
GC14502 AEBSF.HCl
CAS: 30827-99-7
纯度: >99.50% / >98.50% / >98.00% / >99.00%
AEBSF.HCl是丝氨酸蛋白酶广谱的不可逆的抑制剂，可抑制胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶等。
GC14511 All-trans Retinal
CAS: 116-31-4
纯度: >98.00%
All-trans Retinal 是一种具有活性的vitamin A aldehyde，对CRBP-I和CRBP-II蛋白的K d 值分别为50nM和90nM。
GC14533 Kynurenic acid
CAS: 492-27-3
纯度: >99.00% / >98.00%
Kynurenic acid 是一种内源性色氨酸代谢物，是一种针对 NMDA、谷氨酸、α7 烟碱乙酰胆碱受体的广谱拮抗剂。
GC14547 Quinolinic acid
CAS: 89-00-9
纯度: >99.00%
An excitotoxic agonist at NMDA receptors
GC14549 3-Hydroxyphenylacetic acid
CAS: 621-37-4
A phenolic acid with diverse biological activities
GC14573 Xylose
CAS: 25990-60-7
纯度: >98.00%
木糖是有机合成的中间体。
GC14727 CCCP
CAS: 555-60-2
纯度: >98.00% / >99.50%
Carbonylcyanide-3-chlorophenylhydrazone (CCCP) 是一种质子载体，可导致线粒体内膜中的质子梯度解偶联，从而抑制 ATP 合成速率。
GC14751 Malotilate
CAS: 59937-28-9
纯度: >99.50%
A hepatoprotective agent
GC14757 AGI-6780
CAS: 1432660-47-3
纯度: >98.00%
A potent, selective inhibitor of mutant IDH2
GC14762 Palifosfamide
CAS: 31645-39-3
An active metabolite of ifosfamide
GC14776 EC 144
CAS: 911397-80-3
EC 144 是一种有效的选择性热休克蛋白 90 (Hsp90) 抑制剂，IC50 为 1.1 nM。 EC 144 抑制肿瘤生长并导致部分肿瘤消退。 EC 144 具有研究癌症疾病的潜力。
GC14780 Oseltamivir acid
CAS: 187227-45-8
纯度: >98.50% / >98.00%
A neuraminidase inhibitor and antiviral
GC14786 P32/98 (hemifumarate)
CAS: 251572-86-8
A DPP IV inhibitor
GC14816 L-Adrenaline
CAS: 51-43-4
纯度: >99.50% / >98.00%
An adrenergic receptor agonist
GC14827 Linagliptin (BI-1356)
CAS: 668270-12-0
纯度: >99.50%
A potent DPP-4 inhibitor
GC14843 Serotonin HCl
CAS: 153-98-0
纯度: >99.50% / >98.00%
Serotonin HCl是一种神经递质，是介导人体多种中枢和外周功能的关键信使。
GC14847 Psoralidin
CAS: 18642-23-4
纯度: >98.00%
A furanocoumarin with anti-cancer activity
GC14851 Vidofludimus
CAS: 717824-30-1
纯度: >98.50%
An immunosuppressive drug that inhibits DHODH
GC14930 Benzbromarone
CAS: 3562-84-3
纯度: >99.50%
An inhibitor of URAT1
GC14943 Hypotaurine
CAS: 300-84-5
纯度: >99.50% / >98.00%
Hypotaurine是牛磺酸生物合成的前体，是甘氨酸受体（glycine receptor）的内源性抑制性氨基酸。
GC14953 Spermine
CAS: 71-44-3
纯度: >99.00% / >97.00%
A natural polyamine
GC14954 L-Canaline
CAS: 496-93-5
纯度: >95.00%
A natural inhibitor of aminotransferases

分类产品列表
货号	产品名称	CAS号	纯度
GC14435	Zileuton sodium	118569-21-4	-
GC14435	A reversible inhibitor of 5-lipoxygenase
GC14441	SW033291	459147-39-8	>98.50% / >99.00% / >98.00%
GC14441	SW033291是15-羟基前列腺素脱氢酶（15-PGDH）的小分子抑制剂，15-PGDH是一种催化PGE2氧化和失活的酶。
GC14502	AEBSF.HCl	30827-99-7	>99.50% / >98.50% / >98.00% / >99.00%
GC14502	AEBSF.HCl是丝氨酸蛋白酶广谱的不可逆的抑制剂，可抑制胰凝乳蛋白酶，激肽释放酶，纤溶酶，凝血酶，胰蛋白酶和相关的溶栓酶等。
GC14511	All-trans Retinal	116-31-4	>98.00%
GC14511	All-trans Retinal 是一种具有活性的vitamin A aldehyde，对CRBP-I和CRBP-II蛋白的K d 值分别为50nM和90nM。
GC14533	Kynurenic acid	492-27-3	>99.00% / >98.00%
GC14533	Kynurenic acid 是一种内源性色氨酸代谢物，是一种针对 NMDA、谷氨酸、α7 烟碱乙酰胆碱受体的广谱拮抗剂。
GC14547	Quinolinic acid	89-00-9	>99.00%
GC14547	An excitotoxic agonist at NMDA receptors
GC14549	3-Hydroxyphenylacetic acid	621-37-4	-
GC14549	A phenolic acid with diverse biological activities
GC14573	Xylose	25990-60-7	>98.00%
GC14573	木糖是有机合成的中间体。
GC14727	CCCP	555-60-2	>98.00% / >99.50%
GC14727	Carbonylcyanide-3-chlorophenylhydrazone (CCCP) 是一种质子载体，可导致线粒体内膜中的质子梯度解偶联，从而抑制 ATP 合成速率。
GC14751	Malotilate	59937-28-9	>99.50%
GC14751	A hepatoprotective agent
GC14757	AGI-6780	1432660-47-3	>98.00%
GC14757	A potent, selective inhibitor of mutant IDH2
GC14762	Palifosfamide	31645-39-3	-
GC14762	An active metabolite of ifosfamide
GC14776	EC 144	911397-80-3	-
GC14776	EC 144 是一种有效的选择性热休克蛋白 90 (Hsp90) 抑制剂，IC50 为 1.1 nM。 EC 144 抑制肿瘤生长并导致部分肿瘤消退。 EC 144 具有研究癌症疾病的潜力。
GC14780	Oseltamivir acid	187227-45-8	>98.50% / >98.00%
GC14780	A neuraminidase inhibitor and antiviral
GC14786	P32/98 (hemifumarate)	251572-86-8	-
GC14786	A DPP IV inhibitor
GC14816	L-Adrenaline	51-43-4	>99.50% / >98.00%
GC14816	An adrenergic receptor agonist
GC14827	Linagliptin (BI-1356)	668270-12-0	>99.50%
GC14827	A potent DPP-4 inhibitor
GC14843	Serotonin HCl	153-98-0	>99.50% / >98.00%
GC14843	Serotonin HCl是一种神经递质，是介导人体多种中枢和外周功能的关键信使。
GC14847	Psoralidin	18642-23-4	>98.00%
GC14847	A furanocoumarin with anti-cancer activity
GC14851	Vidofludimus	717824-30-1	>98.50%
GC14851	An immunosuppressive drug that inhibits DHODH
GC14930	Benzbromarone	3562-84-3	>99.50%
GC14930	An inhibitor of URAT1
GC14943	Hypotaurine	300-84-5	>99.50% / >98.00%
GC14943	Hypotaurine是牛磺酸生物合成的前体，是甘氨酸受体（glycine receptor）的内源性抑制性氨基酸。
GC14953	Spermine	71-44-3	>99.00% / >97.00%
GC14953	A natural polyamine
GC14954	L-Canaline	496-93-5	>95.00%
GC14954	A natural inhibitor of aminotransferases