Serotonin HCl a neurotransmitter, is a key messenger that mediates several central and peripheral functions in the human body[1]. Serotonin HCl is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 µM[2].
In vitro, Serotonin HCl (1 nmol/L-10 micromol/L) caused vasoconstriction in a concentration-dependent manner[3]. In vitro, 10 μM Serotonin HCl proliferates colon cancer cells through enhancing YAP (Yes-associated protein) expression[1]. In vitro, for left lower lobe of lungs isolated from the dog, infusion of Serotonin HCl (100 micrograms/min) increased the pulmonary pre- and post-capillary resistances, but did not change the filtration coefficient[4].
In vivo, topical Serotonin HCl (1-10 nmols) or the Serotonin HCl1/7 receptor agonist, 5-carboxamidotryptamine (10-30 nM), dilated third- and fourth-order arterioles, responses that were abolished by 1 μM SB269970, a selective Serotonin HCl7 receptor antagonist[5].
References:
[1] Yu H, et al. Serotonin acts through YAP to promote cell proliferation: mechanism and implication in colorectal cancer progression. Cell Commun Signal. 2023 Apr 12;21(1):75.
[2] Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25.
[3] Tanaka N, et al. Both 5-hydroxytryptamine 5-HT2A and 5-HT1B receptors are involved in the vasoconstrictor response to 5-HT in the human isolated internal thoracic artery. Clin Exp Pharmacol Physiol. 2008 Jul;35(7):836-40.
[4] Sumita T, et al. 5-Hydroxytryptamine receptor subtypes participating in pulmonary edema in dogs. Eur J Pharmacol. 1989 May 2;164(1):69-75.
[5] Jackson WF, et al. 5-HT7 receptors mediate dilation of rat cremaster muscle arterioles in vivo.Microcirculation. 2023 Aug;30(5-6):e12808.
Serotonin HCl是一种神经递质，是介导人体多种中枢和外周功能的关键信使[1]。
在体外，Serotonin HCl（1 nmol/L-10 micromol/L）以浓度依赖的方式引起血管收缩[2]。在体外，10 μM 5-HT通过增强YAP（Yes-associated protein）的表达来增殖结肠癌细胞[1]。在体外，对于从狗身上分离的左肺下叶，输注Serotonin HCl（100微克/分钟）会增加肺毛细血管前和毛细血管后的阻力，但不会改变过滤系数[3]。
在体内，局部Serotonin HCl（1-10 nmols）或Serotonin HCl 1/7受体激动剂5-甲酰胺色氨酸（10-30 nM）扩张第三和第四级小动脉，反应被1μM SB269970（一种选择性Serotonin HCl 7受体拮抗剂）消除[4]。