(-)-Epigallocatechin Gallate sulfate (EGCG) is a major polyphenol in green tea that inhibits cell proliferation and induces apoptosis[1-2]. EGCG has free radical scavenging properties[3]. EGCG has anti-inflammatory and anti-apoptotic effects against oxidative stress in neurons[4].In addition, it inhibits the activity of glutamate dehydrogenase 1/2 (GDH1/2, GLUD1/2) [5].
(-)- Epigallocatechin Gallate(EGCG) (200 µM; 1 h) downregulates expression levels of pro-inflammatory cytokine and mediators in CoCl2-treated BV2 cells[6]. EGCG inhibits 3T3-L1 cell growth via miR-143/MAPK7 pathway[7].
(-)- Epigallocatechin Gallate(EGCG) (5 -30 mg/kg; i.g; 14 days) reduces tumor(HT-29 colorectal cancer) growth[8]. EGCG treatment(50 mg/kg per day) dissolved in corn oil was administrated via intraperitoneal injection from day 7 to 11 at 1 h before house dust mite (HDM) challenge) relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages[9].
References:
[1]. Jin CF, Shen SR Sr, et,al. Different effects of five catechins on 6-hydroxydopamine-induced apoptosis in PC12 cells. J Agric Food Chem. 2001 Dec;49(12):6033-8. doi: 10.1021/jf010903r. PMID: 11743804.
[2]. De Amicis F, Perri A, et,al. Epigallocatechin gallate inhibits growth and epithelial-to-mesenchymal transition in human thyroid carcinoma cell lines. J Cell Physiol. 2013 Oct;228(10):2054-62. doi: 10.1002/jcp.24372. PMID: 23553645.
[3]. Kondo K, Kurihara M, et,al. Scavenging mechanisms of (-)-epigallocatechin gallate and (-)-epicatechin gallate on peroxyl radicals and formation of superoxide during the inhibitory action. Free Radic Biol Med. 1999 Oct;27(7-8):855-63. doi: 10.1016/s0891-5849(99)00133-1. PMID: 10515590.
[4]. Schroeder EK, Kelsey NA, et,al. Green tea epigallocatechin 3-gallate accumulates in mitochondria and displays a selective antiapoptotic effect against inducers of mitochondrial oxidative stress in neurons. Antioxid Redox Signal. 2009 Mar;11(3):469-80. doi: 10.1089/ars.2008.2215. PMID: 18754708.
[5]. Peeters TH, Lenting K, et,al. Isocitrate dehydrogenase 1-mutated cancers are sensitive to the green tea polyphenol epigallocatechin-3-gallate. Cancer Metab. 2019 May 20;7:4. doi: 10.1186/s40170-019-0198-7. PMID: 31139406; PMCID: PMC6526618.
[6]. Kim SR, Seong KJ, et,al. Epigallocatechin Gallate Protects against Hypoxia-Induced Inflammation in Microglia via NF-κB Suppression and Nrf-2/HO-1 Activation. Int J Mol Sci. 2022 Apr 4;23(7):4004. doi: 10.3390/ijms23074004. PMID: 35409364; PMCID: PMC8999549.
[7]. Chen CP, Su TC, et,al. Green tea epigallocatechin gallate suppresses 3T3-L1 cell growth via microRNA-143/MAPK7 pathways. Exp Biol Med (Maywood). 2022 Sep;247(18):1670-1679. doi: 10.1177/15353702221108925. Epub 2022 Jul 27. PMID: 35894140; PMCID: PMC9597208.
[8]. Jin H, Gong W, et,al. Epigallocatechin gallate inhibits the proliferation of colorectal cancer cells by regulating Notch signaling. Onco Targets Ther. 2013;6:145-53. doi: 10.2147/OTT.S40914. Epub 2013 Mar 8. PMID: 23525843; PMCID: PMC3596123.
[9]. Yang N, Li X. Epigallocatechin gallate relieves asthmatic symptoms in mice by suppressing HIF-1α/VEGFA-mediated M2 skewing of macrophages. Biochem Pharmacol. 2022 Aug;202:115112. doi: 10.1016/j.bcp.2022.115112. Epub 2022 May 29. PMID: 35640712.
(-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡[1-2]。EGCG具有清除自由基的特性[3]。EGCG对神经元氧化应激具有抗炎和抗凋亡作用[4]。此外,它还能抑制谷氨酸脱氢酶1/2 (GDH1/2, GLUD1/2)的活性[5]。
(-)-Epigallocatechin Gallate sulfate (EGCG) (200 µM; 1 h)下调CoCl2处理BV2细胞中促炎细胞因子和介质的表达水平[6]。(-)-Epigallocatechin Gallate sulfate (EGCG)通过miR-143/MAPK7途径抑制3T3-L1细胞生长[7]。
(-)-Epigallocatechin Gallate sulfate (EGCG) (5 -30 mg/kg; i.g; 14 days)减少肿瘤(HT-29结直肠癌)的生长[8]。(-)-Epigallocatechin Gallate sulfate (EGCG)治 (50 mg/kg / d)溶解于玉米油中,于第7天至第11天室内尘螨(HDM)处理前1 h腹腔注射)通过抑制HIF-1α/ vegfa介导的巨噬细胞M2偏移来缓解小鼠哮喘症状[9]。