Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC41666 (±)9-HODE cholesteryl ester A racemic monohydroxy fatty acid cholesteryl ester
GC30586 (±) Anabasine

八角枫碱
(±)Anabasine是一种肌肉松弛剂，可用于外科手术时肌肉松驰。
GC61647 (+)-Longifolene

长叶烯
(+)-Longifolene is a naturally occurring, oily liquid hydrocarbon found primarily in the high-boiling fraction of certain pine resins
GC10675 (+,-)-Octopamine HCl

章胺盐酸盐; (±)-p-Octopamine hydrochloride
An endogenous biogenic amine
GC45245 (-)-Caryophyllene oxide

石竹素,(-)-Caryophyllene oxide
A bicyclic sesquiterpene
GC17470 (-)-Cotinine

可替宁; (-)-Cotinine; (S)-Cotinine; NIH-10498
A major metabolite of nicotine
GC17242 (-)-epigallocatechin

(-)-表没食子儿茶素; Epigallocatechin; L-Epigallocatechin
A green tea polyphenol
GC14049 (-)-Epigallocatechin gallate (EGCG)

(-)-表没食子儿茶素没食子酸酯,EGCG
(-)-Epigallocatechin Gallate sulfate (EGCG) 是绿茶中的一种主要多酚,可抑制细胞增殖并诱导细胞凋亡。
GC40218 (-)-Epigallocatechin Gallate-d3/d4

EGCG-d3/d4
An internal standard for the quantification of (–)-epigallocatechin gallate
GC34951 (-)-Menthol

L-薄荷醇
A monoterpene with diverse biological activities
GC90533 (-)-Pinoresinol
一种具有多种生物活性的木脂素
GC45252 (-)-Sitagliptin Carbamoyl Glucuronide

BETA-D-吡喃葡萄糖醛酸1-[N-[(1R)-3-[5,6-二氢-3-(三氟甲基)-1,2,4-三唑并[4,3-A]吡嗪-7(8H)-基]-3-氧代-1-[(2,4,5-三氟苯基)甲基]丙基]氨基甲酸酯]
A minor phase II metabolite of (–)-sitagliptin
GC72832 (1R)-IDH889 (1R)-IDH889是IDH889的异构体并且可以用作实验对照。
GC18622 (2'S)-Nicotine-1-oxide

(2'S)-尼古丁氧化物
A nicotine metabolite
GC38299 (2-Aminoethyl)phosphonic acid

2-氨基乙基膦酸
2-Aminoethylphosphonic acid (2-AEP, (2-Aminoethyl)phosphonic acid) is a type of abundant and ubiquitous naturally occurring phosphonate used as sources of phosphorus by many prokaryotic lineages.
GC68509 (25R)-12α-Hydroxyspirost-4-en-3-one (25R)-12α-Hydroxyspirost-4-en-3-one 是由 Nocardia globerula 作用于 Hecogenin 产生的一种次要代谢物。
GC38265 (2R,3R)-2,3-Dihydroxysuccinic acid

L-酒石酸; L-(+)-Tartaric acid
Tartaric acid (2,3-Dihydroxysuccinic acid, Threaric acid, Racemic acid, Uvic acid, Paratartaric acid, Winestone) is a white crystalline organic acid that occurs naturally in many plants, most notably in grapes. It has several applications for industrial and pharmaceutical use.
GC62731 (2R,3R)-Butane-2,3-diol

(2R,3R)-(-)-2,3-丁二醇
(2R,3R)-(-)-2,3-Butanediol ((2R,3R)-Butane-2,3-diol) is an endogenous metabolite.
GC38296 (2S,3R,4S,5R)-2-Amino-3,4,5,6-tetrahydroxyhexanal hydrochloride

盐酸D-甘露糖胺
An amino monosaccharide
GC33797 (3-Carboxypropyl)trimethylammonium chloride

(3-羧丙基)三甲基氯化铵,γ-Butyrobetaine hydrochloride
(3-Carboxypropyl)trimethylammonium chloride (γ-Butyrobetaine, γBB hydrochloride) is an intermediary metabolite by gut microbes from dietary L-carnitine in mice.
GC41694 (3S)-hydroxy Quinidine

(3S)-3-羟基奎尼定
An active quinidine metabolite
GC38283 (3S,4S,5R)-1,3,4,5,6-Pentahydroxyhexan-2-one

D-塔格糖; D-(-)-Tagatose
D-Tagatose is an isomer of fructose and is used as a sweetener in beverages, yogurt, creams, and dietetic candy.
GC12395 (D)-(+)-Neopterin

新蝶呤,D-(+)-Neopterin; D-erythro-Neopterin
A biochemical tool to screen for immune disorders
GC60399 (E)-10-Hydroxynortriptyline

E-10-OH-NT
An active metabolite of amitriptyline and nortriptyline
GC65239 (E)-3,4-(Methylenedioxy)cinnamic acid

(2E)-3-(1,3-苯并二氧杂环戊-5-基)-2-丙烯酸,(E)-Piperonylprop-2-enoic acid
(E)-3,4-(Methylenedioxy)cinnamic acid 是从Brombya platynema的茎皮中获得的肉桂酸衍生物。
GC91418 (E)-KPT-330

KTP-330; trans Selinexor
(E)-KPT-330是selinexor的代谢产物，它是exportin 1 (XPO1/CRM1)抑制剂的一种。它由细胞色素P450（CYP）亚型CYP3A4从selinexor中形成。
GC38684 (E)-m-Coumaric acid

3-羟基肉桂酸
3-hydroxycinnamic acid (meta-Coumaric acid, m-Coumaric acid, m-Coumarate) is an aromatic acid that can be found in vinegar.
GC62734 (E)-Oct-2-enoic acid

2-辛烯酸
2-Octenoic acid (2-Octenoate) is a normal organic acid produced by hepatic microsomal oxidation of aliphatic aldehydes and is a metabolite naturally found in the urine and plasma.
GC40286 (E,Z)-2-propyl-2-Pentenoic Acid

2-丙基-2-戊烯酸
A valproic acid metabolite
GC49189 (E/Z)-4-hydroxy Tamoxifen-d5

Afimoxifene-d5, 4-OHT-d5
An internal standard for the quantification of (E/Z)-4-hydroxy tamoxifen
GC67476 (E/Z)-Sulindac sulfide (E/Z)-Sulindac sulfide 是一种有效的 γ-secretase 调节剂。(E/Z)-Sulindac sulfide 可选择性地减少 Aβ42 产生，有利于更短的 Aβ 类型的产生。(E/Z)-Sulindac sulfide 可用于阿尔兹海默症的研究。
GC60404 (Ethoxymethyl)benzene

苄基乙醚
(Ethoxymethyl)benzene是一种内源性代谢产物。
GA11210 (H-Cys-OH)2

L-胱氨酸
(H-Cys-OH)2 是一种氨基酸和细胞内硫醇，在细胞过程的调节中起关键作用。
GN10783 (R) Ginsenoside Rh2

20(R)-人参皂苷Rh2
A steroid glycoside with diverse biological activities
GC41721 (R)-α-Lipoic Acid

硫辛酸; (R)-(+)-α-Lipoic acid; R-(+)-Thioctic acid
A cyclic disulfide antioxidant
GC34442 (R)-(+)-Citronellal

(R)-(+)-香茅醛; (+)-Citronellal
(R)-(+)-Citronellal可从柑橘、薰衣草和桉树油中分离得到，是一种单萜化合物，是香茅醛的主要成分，具有独特的柠檬香味。是一种调味剂。可用于驱虫和抗真菌。
GC38262 (R)-(-)-1,3-Butanediol

(R)-(-)-1,3-丁二醇
(R)-(-)-1,3-Butanediol 可以用于调节糖类脂类代谢。
GC62737 (R)-(-)-O-Desmethyl Venlafaxine D6

(R)-O-去甲文拉法辛 d6
(R)-(-)-O-Desmethyl Venlafaxine D6 是 (R)-(-)-O-Desmethyl Venlafaxine 的氘代物。O-Desmethyl Venlafaxine 是 Venlafaxine 的活性代谢产物。Venlafaxine 是 5-羟色胺-去甲肾上腺素再摄取抑制剂 (SNRI) 类的抗抑郁剂。
GC30210 (R)-3-Hydroxybutanoic acid

(R)-3-羟基丁酸,(R)-(-)-3-Hydroxybutanoic acid; (R)-3-Hydroxybutyric acid
(R)-3-Hydroxybutanoic acid是一种聚羟基丁酸酯（PHB）单体，能够通过与各种羟基脂肪酸反应制备共聚物，具有工业和医药用途。
GC61759 (R)-3-Hydroxybutanoic acid sodium

(R)-(-)-3-羟基丁酸钠盐; (R)-(-)-3-Hydroxybutanoic acid sodium; (R)-3-Hydroxybutyric acid sodium
(R)-3-Hydroxybutanoicacidsodium((R)-3-Hydroxybutyricacid)是一种代谢物，由3-羟基丁酸脱氢酶催化乙酸乙酯获得。(R)-3-Hydroxybutanoicacidsodium可作为营养来源和维生素、抗生素和信息素的前体。
GC71626 (R)-3-Hydroxybutanoic acid-13C2 sodium (R)-3-Hydroxybutanoic acid-13C2 sodium是13C标记的R-3-羟基丁酸钠。
GC30661 (R)-3-Hydroxyisobutyric acid

(R)-2-羟甲基丙酸

(R)-3-Hydroxyisobutyricacid是l-缬氨酸和胸腺嘧啶途径中的中间产物，在诊断罕见遗传性代谢疾病3-羟异丁酸和甲基丙二醛脱氢酶缺乏症中起着重要的作用。
GC38282 (R)-5-Oxopyrrolidine-2-carboxylic acid

D-焦谷氨酸
A metabolite of D-glutamate
GC19012 (R)-GNE-140

(R)-3-((2-氯苯基)硫基)-4-羟基-6-(4-吗啉苯基)-6-(噻吩-3-基)-5,6-二氢吡啶-2(1H)-酮
(R)-GNE-140 是一种有效的乳酸脱氢酶 A (LDHA) 抑制剂，对 LDHA 和 LDHB 的 IC50 分别为 3 nM 和 5 nM； (R)-GNE-140 的效力是 S 对映体的 18 倍。
GC52290 (R)-HTS-3 An inhibitor of LPCAT3
GC61858 (R)-MLN-4760 (R)-MLN-4760 是 MLN-4760 的活性较低的 R 型异构体，是一种 ACE2 抑制剂，IC50 值为 8.4 µM。
GC38364 (R)-Ornithine hydrochloride

D-鸟氨酸盐酸盐,(R)-Ornithine hydrochloride

An enantiomer of L-ornithine
GC38363 (R)-pyrrolidine-2-carboxylic acid

D-脯氨酸,(+)-(R)-Proline; (R)-(+)-Proline; (R)-2-Carboxypyrrolidine; (R)-Proline
D-proline is an isomer of the naturally occurring amino acid, L-Proline.
GC38720 (R)-Trolox

(R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
(R)-Trolox 是水溶性维生素 E 类似物，是一种竞争性酪氨酸酶抑制剂，Ki 值为 0.83 mM，ID50 值为 1.88 mM。(R)-Trolox 具有比 (S) 对映异构体更强的酪氨酸酶亲和力 (Ki 值为 0.61 mM)。
GC39832 (R,R)-(+)-Hydrobenzoin

氢胺
(R,R)-(+)-Hydrobenzoin 是一种有机催化剂。