Proteases
Proteases(蛋白酶)
Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.
- Aminopeptidase(21)
- ACE(75)
- Calpains(11)
- Carboxypeptidase(9)
- Cathepsin(65)
- DPP-4(18)
- Elastase(25)
- Gamma Secretase(50)
- HCV Protease(39)
- HSP(105)
- HIV Integrase(30)
- HIV Protease(35)
- MMP(195)
- NS3/4a protease(4)
- Serine Protease(19)
- Thrombin(47)
- Urokinase(2)
- Cysteine Protease
- Tyrosinases(50)
- Other Proteases(15)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(14)
- Acyltransferase(64)
- Aldehyde Dehydrogenase (ALDH)(30)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(49)
- Drug Metabolite(513)
- E1/E2/E3 Enzyme(92)
- Endogenous Metabolite(1768)
- FABP(9)
- Farnesyl Transferase(20)
- Glutaminase(17)
- Glutathione Peroxidase(35)
- Isocitrate Dehydrogenase (IDH)(28)
- Lactate Dehydrogenase(19)
- Lipoxygenase(274)
- Mitochondrial Metabolism(260)
- NEDD8-activating Enzyme(6)
- Neprilysin(12)
- PAI-1(14)
- Ser/Thr Protease(49)
- Tryptophan Hydroxylase(12)
- Xanthine Oxidase(18)
- MALT1(10)
- Caspase(117)
- PCSK9(13)
- ADAMTS(1)
- Density Lipoprotein
- TrxR(1)
- DGK(3)
Proteases 相关产品(4079)
- GC15493Enalaprilat DihydrateCAS: 84680-54-6纯度: >98.00%
Enalaprilat Dihydrate是一种具有口服活性的血管紧张素转换酶（ACE）抑制剂，在体内可迅速水解为活性代谢物Enalaprilat，Enalaprilat通过抑制血管紧张素II的生成，有效舒张血管，降低血压，并减轻心脏负荷。
- GC15577Bestatin hydrochlorideCAS: 65391-42-6纯度: >99.50% / >99.00%
Bestatin hydrochloride是氨基肽酶N（APN/CD13）抑制剂，其IC 50 值为14.9±3.4μM。
- GC16316Q-VD-OPh hydrateCAS: 1135695-98-5纯度: >99.50% / >97.00%
Q-VD-OPh hydrate是一种广谱、可渗透细胞、高效且无毒的caspase抑制剂，对重组caspase1,3,8和9的IC 50 值在25-400nM范围内。
- GC16530Batimastat (BB-94)CAS: 130370-60-4纯度: >98.50% / >98.00%
Batimastat (BB-94)是一种有效的广谱基质金属蛋白酶（MMPs）抑制剂，能够抑制MMP-1，MMP-2，MMP-9，MMP-7和MMP-3，IC 50 值分别为3nM，4nM，4nM，6nM和20nM。
- GC16966VER 155008CAS: 1134156-31-2纯度: >99.50%
VER 155008是一种强效的，源自腺苷的热休克蛋白70（Hsp70）家族抑制剂，对Hsp70、热休克同源蛋白70（Hsc70）和葡萄糖调节蛋白78（Grp78）的IC 50 值分别为0.5μM、2.6μM和2.6μM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC13467 | PMPA (NAALADase inhibitor) | 173039-10-6 | >98.00% | |
A potent inhibitor of GCP II/NAALADase | ||||
| GC13487 | ARP 100 | 704888-90-4 | >99.00% / >98.00% | |
A selective inhibitor of MMP-2 | ||||
| GC13673 | BMS-708163 (Avagacestat) | 1146699-66-2 | >98.00% | |
A potent inhibitor of γ-secretase | ||||
| GC13716 | Lopinavir | 192725-17-0 | >99.50% / >99.00% | |
A potent HIV-1 protease inhibitor | ||||
| GC13750 | Doxycycline HCl | 10592-13-9 | - | |
Doxycycline HCl 是一种抗生素，是一种具有口服活性的广谱金属蛋白酶 (MMP) 抑制剂。 | ||||
| GC14322 | MPC-3100 | 958025-66-6 | - | |
An inhibitor of Hsp90 | ||||
| GC14523 | GM 6001 | 142880-36-2 | >98.00% | |
GM 6001 是一种广谱 MMP 抑制剂，可用于癌症和神经退行性疾病的研究，GM 6001对 MMP-1、2、3、8 和 9 的 Ki 值分别为 0.4、0.5、27、0.1和 0.2 nM。 | ||||
| GC14785 | Alvelestat | 848141-11-7 | >99.50% | |
An inhibitor of neutrophil elastase | ||||
| GC14870 | OSMI-1 | 1681056-61-0 | >98.00% / >99.50% | |
OSMI-1是一种O-GlcNAc转移酶（OGT）小分子抑制剂，不会显著影响其他糖基转移酶。 | ||||
| GC15066 | Z-FA-FMK | 197855-65-5 | >98.00% | |
An inhibitor of cysteine proteases, including cathepsin B | ||||
| GC15180 | BIBR-1048 | 211915-06-9 | >99.50% | |
A prodrug form of dabigatran | ||||
| GC15390 | Dabigatran etexilate mesylate | 872728-81-9 | >98.00% | |
A prodrug form of dabigatran | ||||
| GC15493 | Enalaprilat Dihydrate | 84680-54-6 | >98.00% | |
Enalaprilat Dihydrate是一种具有口服活性的血管紧张素转换酶（ACE）抑制剂，在体内可迅速水解为活性代谢物Enalaprilat，Enalaprilat通过抑制血管紧张素II的生成，有效舒张血管，降低血压，并减轻心脏负荷。 | ||||
| GC15561 | MK-2048 | 869901-69-9 | - | |
MK-2048 是一种有效的整合酶和 INR263K 抑制剂，IC50 分别为 2.6 nM 和 1.5 nM。 | ||||
| GC15577 | Bestatin hydrochloride | 65391-42-6 | >99.50% / >99.00% | |
Bestatin hydrochloride是氨基肽酶N（APN/CD13）抑制剂，其IC 50 值为14.9±3.4μM。 | ||||
| GC15760 | Ramipril | 87333-19-5 | >98.00% | |
A prodrug from of ramiprilat | ||||
| GC16293 | BIBR 953 (Dabigatran, Pradaxa) | 211914-51-1 | >98.50% | |
A thrombin inhibitor | ||||
| GC16316 | Q-VD-OPh hydrate | 1135695-98-5 | >99.50% / >97.00% | |
Q-VD-OPh hydrate是一种广谱、可渗透细胞、高效且无毒的caspase抑制剂，对重组caspase1,3,8和9的IC 50 值在25-400nM范围内。 | ||||
| GC16530 | Batimastat (BB-94) | 130370-60-4 | >98.50% / >98.00% | |
Batimastat (BB-94)是一种有效的广谱基质金属蛋白酶（MMPs）抑制剂，能够抑制MMP-1，MMP-2，MMP-9，MMP-7和MMP-3，IC 50 值分别为3nM，4nM，4nM，6nM和20nM。 | ||||
| GC16892 | XL-888 | 1149705-71-4 | >99.50% | |
An orally bioavailable Hsp90 inhibitor | ||||
| GC16901 | PSI-6206 | 863329-66-2 | >99.50% | |
An inactive derivative of a HCV NS5B inhibitor | ||||
| GC16966 | VER 155008 | 1134156-31-2 | >99.50% | |
VER 155008是一种强效的，源自腺苷的热休克蛋白70（Hsp70）家族抑制剂，对Hsp70、热休克同源蛋白70（Hsc70）和葡萄糖调节蛋白78（Grp78）的IC 50 值分别为0.5μM、2.6μM和2.6μM。 | ||||
| GC18004 | MK-5172 | 1350514-68-9 | >99.50% | |
MK-5172是一种丙型肝炎病毒（HCV）NS3/4a蛋白酶选择性抑制剂，对多种基因型及耐药变异株均具有广谱活性，并能抑制SARS-CoV-2 3CL蛋白酶活性。 | ||||
| GC18065 | ZJ 43 | 723331-20-2 | - | |
ZJ 43 是一种有效的 NAAG 肽酶抑制剂，IC50 为 2.4 nM，Ki 为 0.8 nM。 | ||||