Proteases(蛋白酶)

Proteases, also known as peptidases or proteolytic enzymes, consists of a large number of enzymes catalyzing the hydrolysis of peptide bonds and subsequently resulting in the degradation of protein substrates into amino acids. Proteases are involved in a wide range of human diseases, including cancer, neurodegenerative disorders, inflammatory diseases and cardiovascular diseases. Thus numerous proteases inhibitors (small molecules and proteins) have been identified to block activity of proteases. Proteases inhibitors can be classified into different types based on the class of proteases they inhibit through two general mechanisms, irreversible “trapping” reactions and reversible tight-binding reactions. Proteases inhibitors have been used as diagnostic or therapeutic agents for the treatment of proteases-related diseases.

Products for Proteases

Cat.No. 产品名称 Information
GC41722 (R,S)-Carvedilol Glucuronide

卡维地洛葡糖苷酸
A phase II metabolite of carvedilol
GC34417 (R,S)-Ivosidenib ((R,S)-AG-120) (R,S)-Ivosidenib是一种异柠檬酸脱氢酶(IDH1)抑制剂。
GC60410 (Rac)-3′-Hydroxy simvastatin

辛伐他汀杂质
(Rac)-3′-Hydroxysimvastatin是一种Simvastatin代谢物。Simvastatin是一种竞争性的HMG-CoA还原酶抑制剂，Ki值为0.2nM。
GC68414 (Rac)-Atropine-d3

(Rac)-Tropine tropate-d3; (Rac)-Hyoscyamine-d3
(Rac)-Atropine-d3 是 (Rac)-Atropine 的氘代物。
GC67993 (Rac)-Cotinine-d4

(±)-Cotinine-d4; (Rac)-NIH-10498-d4
(Rac)-Cotinine-d4 是 (Rac)-Cotinine 的氘代物。
GC73585 (Rac)-M826 (Rac)-M826是M826的外消旋体。
GC62744 (Rac)-OSMI-1 (Rac)-OSMI-1 是 OSMI-1 的外消旋体。OSMI-1 是一种 O-GlcNAc 转移酶 (OGT) 抑制剂，IC50 值为 2.7 μM。OSMI-1 抑制哺乳动物细胞系中的蛋白 O-连接的 N-乙酰氨基葡萄糖 (O-GlcNAcylation)，而没有定性地改变细胞表面 N-或 O-连接的聚糖。
GC39833 (S)-(+)-1,2-Propanediol

(S)-1,2-丙二醇
(S)-(+)-1,2-Propanediol 是一种内源性代谢产物。
GC62747 (S)-(-)-Citronellal

(-)-香茅醛; (-?)?-?Citronellal
(-)-Citronellal, a constituent of citronella oil, is used in the synthesis of bioactive compounds.
GC38371 (S)-(-)-Phenylethanol

S-(-)-苯乙醇
(S)-(-)-1-Phenylethanol ((S)-1-Phenylethanol, (S)-(-)-Phenylethanol) is an enantiomer of 1-Phenylethanol with flavor properties.
GC62748 (S)-2-Amino-3-(4-hydroxy-3,5-diiodophenyl)propanoic acid dihydrate

3,5-二碘-L-酪氨酸二水合物
3,5-Diiodotyrosine Dihydrate (Iodogorgoic acid, apothyrin, jodgorgon) is a product from the iodination of monoiodotyrosine. In the biosynthesis of thyroid hormones, diiodotyrosine residues are coupled with other monoiodotyrosine or diiodotyrosine residues to form T4 or T3 thyroid hormones.
GC31630 (S)-2-Hydroxy-3-phenylpropanoic acid

L-3-苯乳酸
(S)-2-Hydroxy-3-phenylpropanoic acid (L-(-)-3-Phenyllactic acid, (2S)-2-Hydroxy-3-phenylpropanoic acid) is a valuable building block in the pharmaceutical and chemical industry—has recently emerged as an important monomer in the composition of the novel degradable biocompatible material of polyphenyllactic acid.
GC64746 (S)-2-Hydroxybutanoic acid

(S)-2-羟基丁酸
(S)-2-Hydroxybutanoic acid 是 2-Hydroxybutanoic acid 的 S-对映异构体。2-Hydroxybutanoic acid 是蛋白质代谢的副产物，是一种胰岛素抵抗 (IR) 生物标志物。
GC31622 (S)-2-Hydroxysuccinic acid

L-苹果酸; (S)-Hydroxybutanedioic acid; (S)-E 296
(S)-2-Hydroxysuccinic acid (L-Malic acid), is a naturally occurring isomer of malic acid, found mainly in sour and unripe fruits.
GC30649 (S)-3,4-Dihydroxybutyric acid (S)-3,4-Dihydroxybutyricacid是一种正常的人体尿液代谢物，在琥珀酸半醛脱氢酶(SSADH)缺乏症患者中浓度增加。
GC64473 (S)-3,4-Dihydroxybutyric acid lithium hydrate (S)-3,4-Dihydroxybutyric acid (lithium hydrate) 是一种正常的人体尿液代谢物，在琥珀酸半醛脱氢酶 (SSADH) 缺乏症患者中浓度增加。
GC62749 (S)-3-Hydroxy-2-(Phosphonooxy)Propanoic Acid

L-GLYCERATE3-PHOSPHATE二钠盐
(S)-3-Hydroxy-2-(Phosphonooxy)Propanoic Acid 是一种内源性代谢产物。
GC30304 (S)-3-Hydroxybutanoic acid ((S)-β-Hydroxybutanoic acid)

(S)-3-羟基丁酸,(S)-β-Hydroxybutanoic acid; L-(+)-3-Hydroxybutyric acid; L-β-Hydroxybutyric acid

(S)-3-Hydroxybutanoic acid ((S)-β-Hydroxybutanoic acid) 是一种正常的人体代谢物，已发现在缓解抑郁症的老年患者中升高。
GC30623 (S)-3-Hydroxyisobutyric acid

2-甲基-3-羟基丙酸
(S)-3-Hydroxyisobutyric acid 是一种重要的器官间代谢物，是 l-缬氨酸和胸腺嘧啶途径的中间体，也是良好的糖异生底物。
GC30148 (S)-b-aminoisobutyric acid

L-3-氨基异丁酸
(S)-b-aminoisobutyricacid是源自胸腺嘧啶和缬氨酸分解代谢的非蛋白质氨基酸。
GC73433 (S)-BAY 2965501 (S)-BAY 2965501是BAY 2965501的左旋异构体。
GC41736 (S)-Dibutyl 3-Hydroxybutyl Phosphate

(S)TBPOH
A compound produced from tributyl phosphate
GC32993 (S)-GNE-140 (S)-GNE-140是活性较小的GNE-140的对映体，能够抑制乳酸脱氢酶A(LDHA)。
GC62751 (S)-Higenamine hydrobromide

(S)-(-)-去甲乌药碱氢溴酸盐,(S)-Norcoclaurine hydrobromide
(S)-Higenamine ((S)-Norcoclaurine) hydrobromide，Higenamine 的 S 型异构体，是苄基异喹啉生物碱生物合成的起始化合物，由去甲月桂碱合酶 (NCS) 将多巴胺和 4-羟基苯乙醛 (4-HPAA) 缩合生成。
GC40145 (S)-Laudanosine

(+)-Laudanosine, L-Laudanosine, L-(+)-Laudanosine, NSC 35045
The (S) enantiomer of laudanosine
GC30735 (S)-Leucic acid

(S)-2-羟基-4-甲基戊酸
Leucic acid ((S)-α-hydroxyisocaproic acid) is a metabolite of the branched chain amino acid known as leucine, which plays a significant role in the synthesis of muscle protein.
GC69914 (S)-Malic acid-d3

(S)-Hydroxybutanedioic acid-d₃; (S)-E 296-d₃
(S)-Malic acid-d3 是 (S)-Malic acid 的氘代物。(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是一种天然存在的二羧酸，水果酸甜味的来源，常用作食品添加剂。
GC35003 (S)-Nornicotine

3-(吡咯烷-2-基)吡啶
(S)-Nornicotine 是尼古丁的代谢物。
GC49179 (S)-O-Desmethyl Naproxen

萘普生杂质A
A metabolite of (S)-naproxen
GC60419 (S)-O-Desmethyl Venlafaxine N-Oxide

S-O-去甲-文拉法辛N-氧化物
(S)-O-DesmethylVenlafaxineN-Oxide是(S)-O-DesmethylVenlafaxine的N-氧化物。O-DesmethylVenlafaxine是Venlafaxine的活性代谢产物。Venlafaxine是5-羟色胺-去甲肾上腺素再摄取抑制剂(SNRI)类的抗抑郁剂。
GC65883 (S,R)-WT IDH1 Inhibitor 2

GSK321
(S,R)-WT IDH1 Inhibitor 2 (GSK321) 是一个有效的选择性突变型 IDH1 抑制剂，抑制 R132G、R132C、R132H 和 WT IDH1 的 IC50 值分别为 2.9、3.8、4.6 和 46 nM，选择性比 IDH2 高出 100 倍。(S,R)-WT IDH1 Inhibitor 2 诱导细胞内 2-HG 减少，髓细胞分化阻滞失效，在白血病母细胞和更不成熟的干细胞水平诱导粒细胞分化。(S,R)-WT IDH1 Inhibitor 2 可用于急性髓系白血病 (AML) 及其他癌症的研究。
GC67682 (S,S)-GSK321 (S,S)-GSK321 是 GSK321 的 (S,S)-对映异构体。
GC64535 (S,S)-TAPI-1

TAPI
A TACE inhibitor
GC60427 (Z)-10-Hydroxynortriptyline

Z-10-羟基去甲替林
An active metabolite of amitriptyline and nortriptyline
GC67761 (Z)-10-Hydroxynortriptyline-d3 (Z)-10-Hydroxynortriptyline-d3 是 (Z)-10-Hydroxynortriptyline 的氘代物。(Z)-10-Hydroxynortriptyline 是 Nortriptyline 的代谢物。Nortriptyline 是三环类抗抑郁药，是 Amitriptyline 的主要活性代谢物，用于缓解抑郁症状。
GC11847 (Z-Ala-Ala-Ala-Ala)2Rh110

(Z-Ala-Ala-Ala-Ala)2Rhodamine110|bis-(CBZ-L-alanyl-L-arginine amide) Rhodamine 110

A fluorogenic elastase substrate
GC18596 (±)-2-propyl-4-Pentenoic Acid

2-丙基-4-五烯酸,2-Allylpentanoic Acid, 4-ene VPA
A metabolite of valproic acid
GC16375 (±)-Jasmonic Acid methyl ester

甲基茉莉酮酸酯,(±)-Methyl Jasmonate
A plant growth regulator
GC45978 1,10-Phenanthroline (hydrate)

邻菲罗啉,1,10-Phenanthroline monohydrate
A metal chelator and inhibitor of metalloproteases
GC41765 1,2,3-Tri-13(Z)-Docosenoyl-rac-glycerol

三芥精
A triacylglycerol
GC41767 1,2,3-Triarachidonoyl-rac-glycerol

三花生精
A triacylglycerol
GC41768 1,2,3-Tridecanoyl-rac-glycerol

甘油三癸酸酯; Tricaprin; Glyceryl tridecanoate
A triacylglycerol
GC41770 1,2,3-Trieicosapentaenoyl-rac-glycerol

二十碳五烯酸甘油三酯(CIS-5,8,11,14,17)
A polyunsaturated triacylglycerol
GC45948 1,2,3-Trilinoelaidoyl-rac-glycerol

十八碳二烯酸甘油三酯(TRANS-9,12)
A triacylglycerol
GC46041 1,2,3-Trilinoleoyl-rac-glycerol

甘油三亚油酸酯
A triacylglycerol
GC41774 1,2,3-Trimyristoyl-rac-glycerol

三肉豆蔻酸甘油酯
A triacylglycerol
GC41776 1,2,3-Trioleoyl-rac-glycerol

三油酸甘油酯
A triacylglycerol
GC41778 1,2,3-Tripalmitoyl-rac-glycerol

(三)棕榈酸甘油酯
A triacylglycerol
GC39766 1,2-Cyclohexanedione

1,2-环己二酮
1,2-环己二酮（1,2-Cyclohexanedione）是一种有机化合物，是三种同分异构的环己二酮之一。它是一种无色化合物，可溶于多种有机溶剂。由二氧化硒氧化环己酮而得
GC41804 1,2-Dimyristoyl-sn-glycero-3-PE

1,2-十四酰基磷脂酰乙醇胺
A phospholipid