(4-Carboxybutyl-d4)triphenylphosphonium (bromide) is intended for use as an internal standard for the quantification of (4-carboxybutyl)triphenylphosphonium by GC- or LC-MS. (4-Carboxybutyl)triphenylphosphonium is a Wittig reagent.1 It has been used in the synthesis of prostaglandin F2α and the monounsaturated fatty acid 7-methyl-6-octadecenoic acid.1,2 (4-Carboxybutyl)triphenylphosphonium has also been used to enhance mitochondrial localization of albumin nanoparticles loaded with the anticancer agent docetaxel .3
1.Stork, G., Sher, P.M., and Chen, H.-L.Radical cyclization-trapping in the synthesis of natural products. A simple, stereocontrolled route to prostaglandin F2αJ. Am. Chem. Soc.108(20)6384-6385(1986) 2.Carballeira, N.M.Recent developments in the total synthesis of bioactive marine fatty acidsStudies in Natural Products Chemistry63-94(2002) 3.Battogtokh, G., Gotov, O., Kang, J.H., et al.Triphenylphosphine-docetaxel conjugate-incorporated albumin nanoparticles for cancer treatmentNanomedicine (Lond.)13(3)325-338(2018)