GlpBio

mAChR

mAChR(毒蕈碱型乙酰胆碱受体)

mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.

mAChR 相关产品(183)

  • GC17779 structure
    GC17779Levetiracetam
    CAS: 102767-28-2
    纯度: >99.50%

    An antiepileptic compound

  • GC17821 structure
    GC17821VU 0365114
    CAS: 1208222-39-2
    纯度: >99.50%

    A positive allosteric modulator of muscarinic M 5 receptors

  • GC17825 structure
    GC17825Methscopolamine
    CAS: 155-41-9

    A muscarinic acetylcholine receptor antagonist

  • GC17908 structure
    GC17908Homatropine Methylbromide
    CAS: 80-49-9
    纯度: >98.00%

    An anticholinergic agent

  • GC17954 structure
    GC17954Tolterodine tartrate
    CAS: 124937-52-6
    纯度: >99.50%

    A muscarinic acetylcholine receptor antagonist

  • GC18255 structure
    GC18255Xanomeline (oxalate)
    CAS: 141064-23-5
    纯度: >99.50%

    Potent agonist of muscarinic receptors

  • GC30409 structure
    GC30409Elucaine
    CAS: 25314-87-8

    Elucaine是蕈毒碱型乙酰胆碱受体(mAChR)拮抗剂，具有抗溃疡功效。

  • GC30426 structure
    GC30426YM-58790
    CAS: 214558-72-2

    YM-58790是一种有效的M3muscarinic受体拮抗剂，Ki值为15nM。

  • GC30446 structure
    GC30446MHP 133
    CAS: 147340-43-0

    MHP133是一种多靶点抑制剂，可以抑制AChE的活性，KKi值为69μM;同时抑制毒蕈碱M1和M2受体，5HT4受体和咪唑I2受体。

  • GC30809 structure
    GC30809VU0467154
    CAS: 1451993-15-9
    纯度: >99.50%

    A positive allosteric modulator of the M 4 muscarinic acetylcholine receptor

  • GC30812 structure
    GC30812Imidafenacin (KRP-197)
    CAS: 170105-16-5
    纯度: >98.00%

    Imidafenacin (KRP-197, ONO-8025) is a urinary antispasmodic of the anticholinergic class. It is a novel antimuscarinic agent with safety and efficacy, has been clinically used for the treatment of overactive bladder. Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors(IC50=4.13 nM). IC50 value: 0.3 nM(M3).

  • GC30822 structure
    GC30822Solifenacin (YM905)
    CAS: 242478-37-1
    纯度: >98.00%

    Solifenacin (YM905) is a competitive muscarinic receptor antagonist. The binding of acetylcholine to these receptors, particularly the M3 receptor subtype, plays a critical role in the contraction of smooth muscle.

  • GC30836 structure
    GC30836MK-7622 (M1 receptor modulator)
    CAS: 1227923-29-6
    纯度: >98.50%

    A positive allosteric modulator of M 1 mAChRs

  • GC30849 structure
    GC30849DREADD agonist 21
    CAS: 56296-18-5
    纯度: >99.50%

    A muscarinic hM3Dq DREADD agonist

  • GC30859 structure
    GC30859AC260584
    CAS: 560083-42-3
    纯度: >99.00%

    AC260584是M1毒蕈碱受体变构激动剂，pEC50值为7.6。

  • GC30901 structure
    GC30901Scopolamine N-oxide hydrobromide (Hyoscine N-oxide hydrobromide)
    CAS: 6106-81-6

    Scopolamine N-Oxide (Hyoscine N-oxide, Genoscopolamine) is a muscarinic antagonist used to study binding characteristics of muscarinic cholinergic receptors.

  • GC30912 structure
    GC30912Piperidolate hydrochloride
    CAS: 129-77-1
    纯度: >99.50%

    Piperidolate盐酸盐是一种抗胆碱剂，作用于大鼠和狗，可抑制乙酰胆碱引起的肠抽筋。

  • GC30925 structure
    GC30925Benzetimide hydrochloride (R4929)
    CAS: 5633-14-7
    纯度: >98.00%

    A muscarinic acetylcholine receptor antagonist

  • GC30955 structure
    GC30955Cimetropium Bromide (DA-3177)
    CAS: 51598-60-8

    Cimetropium Bromide (DA-3177) (DA-3177) 是一种 mAChR 拮抗剂，用于长期治疗肠易激综合征。

  • GC30968 structure
    GC30968Metixene hydrochloride hydrate
    CAS: 7081-40-5
    纯度: >99.50%

    Metixenehydrochloridehydrate是一种抗胆碱能、抗帕金森剂，能够有效抑制二苯羟乙酸奎宁酯与毒蕈碱受体(muscarinicreceptor)结合，IC50和Kd值分别为55nM和15nM。

  • GC30971 structure
    GC30971Rapacuronium bromide (Org 9487)
    CAS: 156137-99-4
    纯度: >98.00%

    雷帕库溴铵 (Org 9487) (Org 9487) 是一种非去极化神经肌肉阻滞剂，是毒蕈碱乙酰胆碱受体 (mAChR) 的变构调节剂。

  • GC30996 structure
    GC30996Alvameline (Lu 25-109)
    CAS: 120241-31-8

    Alvameline (Lu 25-109) (Lu25-109) 是一种部分 M1 激动剂和 M2/M3 拮抗剂。

  • GC31001 structure
    GC31001Pilocarpine nitrate
    CAS: 148-72-1
    纯度: >98.00%

    Pilocarpinenitrate是一种选择性的M3型毒蕈碱乙酰胆碱受体(M3muscarinicreceptor)激动剂。

  • GC31004 structure
    GC31004Temiverine hydrochloride
    CAS: 136529-33-4

    Temiverinehydrochloride是一种合成的抗胆碱剂。