Benzetimide is a muscarinic acetylcholine receptor (mAChR) antagonist.1 It induces mydriasis and inhibits pilocarpine-induced salivation and lacrimation in rats (ED50s = 0.06 and 0.04 mg/kg, respectively).2
1.Gray, J.A., Lüllmann, H., Mitchelson, F.J., et al.Stereoselective binding in cardiac tissue of the enatiomers of benzetimide, and antimuscarinic drugBr. J. Pharmacol.56(4)485-490(1976) 2.Janssen, P.A.J., and Niemegeers, C.J.E.The peripheral and central anticholinergic properties of benzetimide (R 4929) and other atropine-like drugs as measured in a new anti-pilocarpine test in ratsPsychopharmacologia11(3)231-254(1967)