GlpBio

MK-7622 (M1 receptor modulator)

目录号: GC30836纯度: >98.50%同义词: 3-[(1S,2S)-2-羟基环己基]-6-[(6-甲基-3-吡啶基)甲基]苯并[H]喹唑啉-4(3H)-酮,M1 receptor modulator
A positive allosteric modulator of M1 mAChRs
MK-7622 (M1 receptor modulator)
Cas No.: 1227923-29-6
规格价格库存数量操作
5mg¥549.00现货
1
10mg¥882.00现货
1
50mg¥3,150.00现货
1
100mg¥5,400.00现货
1
10mM (in 1mL DMSO)¥604.00现货
1
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文献被引

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    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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    31, 1291–1307 (2021)

产品描述 Description

MK-7622 is a positive allosteric modulator of muscarinic M1 acetylcholine receptors (mAChRs).1 It increases ACh-induced calcium flux in CHO cells expressing human M1 receptors (EC50 = 21 nM). MK-7622 (0.3 and 1 mg/kg) reverses scopolamine-induced cognitive deficits in an object retrieval detour task in rhesus macaques.

1.Uslaner, J.M., Kuduk, S.D., Wittmann, M., et al.Preclinical to human translational pharmacology of the novel M1 positive allosteric modulator MK-7622J. Pharmacol. Exp. Ther.365(3)556-566(2018)

产品文档 Product Documents

Purity:>98.50%

化学性质Chemical Properties

CAS 号
1227923-29-6
同义词
3-[(1S,2S)-2-羟基环己基]-6-[(6-甲基-3-吡啶基)甲基]苯并[H]喹唑啉-4(3H)-酮,M1 receptor modulator
SMILES
O=C1N([C@@H]2[C@@H](O)CCCC2)C=NC3=C1C=C(CC4=CC=C(C)N=C4)C5=CC=CC=C53
分子式
C25H25N3O2
分子量
399.48 g/mol
溶解性
DMSO : ≥ 100 mg/mL (250.33 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol