mAChR
mAChR(毒蕈碱型乙酰胆碱受体)
mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.
mAChR 相关产品(183)
- GC14703Oxybutynin chlorideCAS: 1508-65-2纯度: >98.00%
An antagonist of muscarinic acetylcholine receptors
- GC15990VU 0238429CAS: 1160247-92-6纯度: >99.50%
A muscarinic M 5 receptor positive allosteric modulator
- GC16059Tarafenacin D-tartrateCAS: 1159101-48-0纯度: >99.50%
Tarafenacin D-tartrate (SVT-40776 D-tartrate) 是一种高度选择性的 M3 毒蕈碱受体拮抗剂 (Ki= 0.19 nM)，选择性是 M2 受体的约 200 倍。
- GC16655VU 0357017 hydrochlorideCAS: 1135242-13-5纯度: >99.00%
An M 1 muscarinic acetylcholine receptor agonist
- GC16791Benztropine mesylateCAS: 132-17-2纯度: >99.50%
An M 1 muscarinic acetylcholine receptor antagonist
- GC17157Cevimeline hydrochloride hemihydrateCAS: 153504-70-2纯度: >98.00%
Cevimeline hydrochloride hemihydrate (SNI-2011) 是乙酰胆碱的奎宁环衍生物，是一种选择性和口服活性的毒蕈碱 M1 和 M3 受体激动剂。
- GC17182Solifenacin succinateCAS: 242478-38-2纯度: >99.00%
A muscarinic M 1 , M 2 , and M 3 receptor antagonist
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC14113 | Oxybutynin | 5633-20-5 | >99.50% | |
An antagonist of muscarinic acetylcholine receptors | ||||
| GC14215 | Cevimeline | 107233-08-9 | >98.00% | |
Cevimeline是一种强效的直接作用muscarinic受体激动剂，具有口服生物利用度。 | ||||
| GC14419 | Bethanechol chloride | 590-63-6 | - | |
A muscarinic acetylcholine receptor agonist | ||||
| GC14703 | Oxybutynin chloride | 1508-65-2 | >98.00% | |
An antagonist of muscarinic acetylcholine receptors | ||||
| GC15029 | Glycopyrrolate | 596-51-0 | >99.00% | |
A muscarinic acetylcholine receptor antagonist | ||||
| GC15150 | Tropicamide | 1508-75-4 | >99.00% | |
A selective muscarinic M 4 antagonist | ||||
| GC15758 | BQCA | 338747-41-4 | >98.50% | |
A positive allosteric modulator of the M 1 mAChR | ||||
| GC15772 | Darifenacin HBr | 133099-07-7 | >98.00% | |
A muscarinic M 3 receptor antagonist | ||||
| GC15990 | VU 0238429 | 1160247-92-6 | >99.50% | |
A muscarinic M 5 receptor positive allosteric modulator | ||||
| GC16059 | Tarafenacin D-tartrate | 1159101-48-0 | >99.50% | |
Tarafenacin D-tartrate (SVT-40776 D-tartrate) 是一种高度选择性的 M3 毒蕈碱受体拮抗剂 (Ki= 0.19 nM)，选择性是 M2 受体的约 200 倍。 | ||||
| GC16073 | Dronedarone | 141626-36-0 | >99.50% | |
An antiarrhythmic agent | ||||
| GC16087 | Fesoterodine Fumarate | 286930-03-8 | - | |
A muscarinic acetylcholine receptor antagonist | ||||
| GC16526 | Atropine | 51-55-8 | >99.50% / >98.50% / >98.00% | |
A non-selective muscarinic acetylcholine receptor antagonist | ||||
| GC16553 | N-Desmethylclozapine | 6104-71-8 | >99.50% | |
An active metabolite of clozapine | ||||
| GC16635 | Diphemanil Methylsulfate | 62-97-5 | >98.00% | |
An anticholinergic agent | ||||
| GC16655 | VU 0357017 hydrochloride | 1135242-13-5 | >99.00% | |
An M 1 muscarinic acetylcholine receptor agonist | ||||
| GC16791 | Benztropine mesylate | 132-17-2 | >99.50% | |
An M 1 muscarinic acetylcholine receptor antagonist | ||||
| GC16819 | VU0152100 | 409351-28-6 | >98.00% | |
A muscarinic M 4 receptor positive allosteric modulator | ||||
| GC16937 | Carbamoylcholine chloride | 51-83-2 | >98.00% / >99.00% | |
Cholinergic receptor agonist | ||||
| GC17157 | Cevimeline hydrochloride hemihydrate | 153504-70-2 | >98.00% | |
Cevimeline hydrochloride hemihydrate (SNI-2011) 是乙酰胆碱的奎宁环衍生物，是一种选择性和口服活性的毒蕈碱 M1 和 M3 受体激动剂。 | ||||
| GC17182 | Solifenacin succinate | 242478-38-2 | >99.00% | |
A muscarinic M 1 , M 2 , and M 3 receptor antagonist | ||||
| GC17256 | Pilocarpine HCl | 54-71-7 | >99.00% / >98.00% | |
A muscarinic acetylcholine receptor agonist | ||||
| GC17483 | Trospium chloride | 10405-02-4 | >99.00% | |
An antagonist of muscarinic receptors | ||||
| GC17760 | Clozapine | 5786-21-0 | >98.00% | |
An atypical antipsychotic | ||||