GlpBio

VU 0238429

目录号: GC15990纯度: >99.50%同义词: HY-12157, ML129
A muscarinic M5 receptor positive allosteric modulator
VU 0238429
Cas No.: 1160247-92-6
规格价格库存数量操作
5mg¥540.00现货
1
10mg¥864.00现货
1
25mg¥1,620.00现货
1
50mg¥2,610.00现货
1
100mg¥4,140.00现货
1
10mM (in 1mL DMSO)¥594.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

VU 0238429 is positive allosteric modulator of muscarinic acetylcholine receptor subtype 5 (mAChR5 or M5), with an EC50 of 1.16 μM.

VU 0238429 is positive allosteric modulator of mAChR5 (M5), with an EC50 of 1.16 μM, >30-fold selectivity versus M1 and M3, with no M2 or M4 potentiator activity[1].

References:
[1]. Bridges TM, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
1160247-92-6
同义词
HY-12157, ML129
化学名
1-(4-methoxybenzyl)-5-(trifluoromethoxy)indoline-2,3-dione
SMILES
FC(F)(OC1=CC=C(C(C2=O)=C1)N(C2=O)CC(C=C3)=CC=C3OC)F
分子式
C17H12F3NO4
分子量
351.28 g/mol
溶解性
<35.13mg/ml in DMSO
保存条件
Store at RT
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol