GlpBio

Tetrabenazine-d6

目录号: GC40180纯度: >99.00%同义词: (+)-丁苯那嗪 D6；(+)-丁苯喹嗪 D6；(+)-特苯那嗪 D6；(+)-四苯喹嗪 D6
An internal standard for the quantification of tetrabenazine
Tetrabenazine-d6
Cas No.: 1392826-25-3
规格价格库存数量操作
500μg¥450.00现货
1
1mg¥810.00现货
1
5mg¥2,700.00现货
1
10mg¥4,950.00现货
1
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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Tetrabenazine-d6 is intended for use as an internal standard for the quantification of tetrabenazine by GC- or LC-MS. Tetrabenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2) that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay). It dose-dependently reduces levels of the monoamines norepinephrine , dopamine , and serotonin in rat brain and has been used to induce depressive-like behavior in animal models. Tetrabenazine (5 mg/kg) improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal medium spiny neurons (MSNs) in a YAC128 transgenic mouse model of Huntington's disease. Formulations containing tetrabenazine have been used in the treatment of chorea associated with Huntington's disease.

产品文档 Product Documents

Purity:>99.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
1392826-25-3
同义词
(+)-丁苯那嗪 D6；(+)-丁苯喹嗪 D6；(+)-特苯那嗪 D6；(+)-四苯喹嗪 D6
SMILES
O=C1[C@H](CC(C)C)CN2[C@](C(C=C(OC([2H])([2H])[2H])C(OC([2H])([2H])[2H])=C3)=C3CC2)([H])C1
分子式
C19H21D6NO3
分子量
323.5 g/mol
溶解性
DMF: 30 mg/ml,DMF:PBS(pH7.2) (1:2): 0.33 mg/ml,DMSO: 25 mg/ml,Ethanol: 10 mg/ml
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol