GlpBio

CaMK

CaMK(钙调蛋白激酶)

The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.

Calcium/calmodulin kinase II (CaMK II) is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.

Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the Ca2+/calmodulin (CaM) dependent kinases (CaMKs) which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.

CaMK 相关产品(32)

  • GC10629 structure
    GC10629KN-93
    CAS: 139298-40-1
    纯度: >99.00%

    KN-93是一种有效的、细胞膜通透性的、选择性Ca 2+ /钙调蛋白依赖性蛋白激酶II（CaMKII）抑制剂，IC 50 值为0.37μM。

  • GC11362 structure
    GC11362K 252a
    CAS: 99533-80-9
    纯度: >98.00%

    A non-selective PKC inhibitor

  • GC12501 structure
    GC12501KN-93 hydrochloride
    CAS: 1956426-56-4
    纯度: >99.00% / >99.50%

    KN-93 hydrochloride是一种有效的、细胞膜通透性的、选择性Ca 2+ /钙调蛋白依赖性蛋白激酶II（CaMKII）抑制剂，IC 50 值为0.37μM。

  • GC12739 structure
    GC12739A 484954
    CAS: 142557-61-7
    纯度: >98.00%

    An eEF-2K inhibitor

  • GC12804 structure
    GC12804KN-93 Phosphate
    CAS: 1913269-12-1
    纯度: >99.50%

    KN-93 Phosphate是一种有效的、细胞膜通透性的、选择性Ca 2+ /钙调蛋白依赖性蛋白激酶II（CaMKII）抑制剂，IC 50 值为0.37μM。

  • GC13793 structure
    GC13793NH125
    CAS: 278603-08-0
    纯度: >98.00%

    NH125是一种多靶标的活性物质，是多种组氨酸蛋白激酶家族成员的抑制剂，其中NH125可抑制真核延长因子2激酶（eEF-2K）活性，IC 50 =60nM。

  • GC14132 structure
    GC14132KN-92
    CAS: 176708-42-2

    An inactive control compound for a CaMKII inhibitor

  • GC14202 structure
    GC14202KN-62
    CAS: 127191-97-3
    纯度: >99.00%

    KN-62是一种选择性钙调蛋白依赖性蛋白激酶II（CaMKII）抑制剂，同时是强效非竞争性P2X7受体拮抗剂。

  • GC14326 structure
    GC14326Calmidazolium chloride
    CAS: 57265-65-3
    纯度: >98.00%

    Calmidazolium chloride是一种高效的Ca 2+ 钙调蛋白依赖性酶抑制剂，其抑制脑磷酸二酯酶、红细胞Ca 2+ -ATP酶和磷酸化酶b激酶的IC 50 值分别为0.01μM、0.2μM和5.0μM。

  • GC15988 structure
    GC15988KN-92 hydrochloride
    CAS: 1431698-47-3
    纯度: >99.50%

    KN-92 hydrochloride是KN-93的非活性类似物，可通过结构修饰转化为KN-93。

  • GC16981 structure
    GC16981KN-92 phosphate
    CAS: 1135280-28-2
    纯度: >99.50%

    KN-92 phosphate 是 KN-93 的无活性衍生物，没有 CaM 激酶抑制活性。 KN-92 磷酸盐旨在用作旨在阐明 KN-93 拮抗剂活性的研究中的对照化合物。 KN-93 是一种细胞渗透性、可逆性和竞争性 CaMKII 抑制剂。

  • GC17329 structure
    GC17329MLCK inhibitor peptide 18
    CAS: 224579-74-2
    纯度: >99.50%

    A selective, cell-permeable inhibitor of MLCK

  • GC30356 structure
    GC30356Metofenazate (Methophenazine)
    CAS: 388-51-2

    Metofenazate (Methophenazine) 是一种选择性钙调蛋白抑制剂。

  • GC31170 structure
    GC31170Calmodulin-Dependent Protein Kinase II 290-309
    CAS: 115044-69-4

    A CaMKII inhibitor

  • GC33683 structure
    GC33683Autocamtide 2 (Autocamtide II)
    CAS: 129198-88-5
    纯度: >98.50%

    Autocamtide 2 (Autocamtide II) 是钙/钙调蛋白依赖性蛋白激酶 II (CaMKII) 的高选择性肽底物。

  • GC33732 structure
    GC33732Syntide 2
    CAS: 108334-68-5

    A protein kinase substrate

  • GC33775 structure
    GC33775Rimacalib (SMP 114)
    CAS: 215174-50-8
    纯度: >99.50%

    Rimacalib (SMP 114) (SMP 114) 是一种 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂，IC50 为 ~1 μ；M 代表 CaMKIIα；至 ~30 μ；M 代表 CaMKIIγ；。

  • GC34390 structure
    GC34390Autocamtide 2, amide
    纯度: >99.00%

    Autocamtide2,amide是钙调蛋白激酶(CaMK)家族实验的底物(100μMfinalconcentration)。

  • GC35432 structure
    GC35432Autocamtide-2-related inhibitory peptide (TFA)
    纯度: >95.00%

    A CaMKII inhibitor

  • GC35601 structure
    GC35601CaMKII-IN-1
    CAS: 1208123-85-6
    纯度: >99.50% / >98.00%

    CaMKII-IN-1是一种强效且高度选择性的CaMKII抑制剂，IC 50 值为63nM。

  • GC35820 structure
    GC35820DDD107498 succinate
    CAS: 2444781-71-7
    纯度: >98.50%

    DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.

  • GC37694 structure
    GC37694STO-609
    CAS: 52029-86-4
    纯度: >98.00%

    STO-609是一种选择性且细胞可渗透的Ca²⁺/钙调蛋白依赖性蛋白激酶激酶（CaM-KK）抑制剂，对重组CaM-KKα和CaM-KKβ的K i 值分别为80ng/mL和15ng/mL。

  • GC37710 structure
    GC37710Syntide 2 (TFA)
    纯度: >99.50%

    A protein kinase substrate

  • GC43128 structure
    GC43128Calmodulin-Dependent Protein Kinase II (290-309) (trifluoroacetate salt)
    纯度: >95.00%

    A CaMKII inhibitor