GlpBio

CaMK

CaMK(钙调蛋白激酶)

The Ca2+/calmodulin-dependent kinase (CaMK) family has been recognized as a key mediator in living organisms and various biological processes.

Calcium/calmodulin kinase II (CaMK II) is a multifunctional cytoplasmic calcium and calmodulin-dependent protein kinase that phosphorylates and alters the function of a variety of substrates. The CaMK II pathway has been found to regulate the RANKL-induced osteoclast formation via the cAMP-response element binding protein (CREB) pathway.

Among many signaling pathways of proliferation, intracellular calciumol/L has been extensively demonstrated to be very important. In cytoplasm, calciumol/L binds to calmodulin, and then activates the Ca2+/calmodulin (CaM) dependent kinases (CaMKs) which are a family of structurally related serine/threonine protein kinases including CaMKI-IV. CaMKII, a multi functional protein kinase, is ubiquitously involved in many physiological processes including control of cell cycle, apoptosis, gene expression, and neurotransmission.

CaMK 相关产品(32)

  • GC50305 structure
    GC50305Autocamtide-2-related inhibitory peptide, myristoylated
    CAS: 201422-04-0

    Autocamtide-2 相关抑制肽，肉豆蔻酰化是肉豆蔻酰化 Autocamtide-2 相关抑制肽。

  • GC60037 structure
    GC60037A-3 hydrochloride
    CAS: 78957-85-4
    纯度: >99.50%

    A-3 hydrochloride, a potent, cell-permeable, reversible, ATP-competitive non-selective antagonist of various kinases, againsts cAMP-dependent protein kinase (PKA) (Ki=4.3 ?M), casein kinase II (CK2) (Ki=5.1 ?M) and myosin light chain kinase (MLCK) (Ki=7.4 ?M), also inhibits Protein Kinase C (PKC) and casein kinase I (CK1) with Ki values of 47 ?M and 80 ?M, respectively.

  • GC61521 structure
    GC61521Calmodulin-Dependent Protein Kinase II(290-309) acetate
    纯度: >98.50%

    Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂，抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。

  • GC62146 structure
    GC62146XST-14
    CAS: 2607143-50-8
    纯度: >99.50%

    XST-14 是一种有效的，竞争性强且高度选择性的 ULK1 抑制剂，IC50 为 26.6 nM。XST-14 通过减少 ULK1 下游底物的磷酸化来诱导自噬抑制。XST-14 诱导肝细胞癌 (HCC) 细胞凋亡，并具有抗肿瘤作用。

  • GC71047 structure
    GC71047TIM-063
    CAS: 2493978-38-2
    纯度: 不显示

    TIM-063CaMKKα和CaMKKβ的Ki值分别为0.35μM和0.2μM，IC50值分别为0.63μM和0.96μM。

  • GC71066 structure
    GC71066CS587
    CAS: 2388506-69-0
    纯度: >98.00%

    CS587是CaMK1D的特异性抑制剂，在10μM时具有神经细胞毒性。

  • GC72206 structure
    GC72206Autocamtide-3 acetate
    纯度: >99.00%

    Autocamtide-3 acetate含有Thr287的13个氨基酸的肽是选择性CaMKII（Ca2+/钙调素依赖性激酶II）（CaMK）底物。

  • GC91849 structure
    GC91849Autocamtide-2-related Inhibitory Peptide (trifluoroacetate salt)
    纯度: >95.00%

    Autocamtide-2-related inhibitory peptide is a calmodulin-dependent protein kinase II (CaMKII) inhibitor (IC50 = 40 nM) that was designed based on the sequence around the autophosphorylation site (Thr286/Thr287) in the autoinhibitory domain of the protein kinase.