KN-92 hydrochloride is an inactive analogue of KN-93 and can be converted to KN-93 by modification[1]. KN-92 hydrochloride has a weak ionic current inhibition activity and can inhibit some Kv channels[2]. KN-92 hydrochloride is often used as a negative control to elucidate the inhibitory activity of KN-93 on CaMKII in mammalian eggs[3]. KN-92 hydrochloride can be used as a model compound to develop a new HPLC-MS technology for the identification of related substances[4].
References:
[1] Bruno C, Lentini G, Catalano A, et al. Microwave-Assisted Synthesis of KN-93, a Potent and Selective Inhibitor of Ca2+/Calmoduline-Dependent Protein Kinase II[J]. Synthesis, 2010, 2010(24): 4193-4198.
[2] Rezazadeh S, Claydon T W, Fedida D. KN-93 (2-[N-(2-hydroxyethyl)]-N-(4-methoxybenzenesulfonyl)] amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels[J]. The Journal of pharmacology and experimental therapeutics, 2006, 317(1): 292-299.
[3] Tatone C, Iorio R, Francione A, et al. Biochemical and biological effects of KN-93, an inhibitor of calmodulin-dependent protein kinase II, on the initial events of mouse egg activation induced by ethanol[J]. Reproduction, 1999, 115(1): 151-157.
[4] Erwin T, Rekulapally S P, Abraham T S, et al. A non-radioactive in vitro CaMKII activity assay using HPLC-MS[J]. Journal of Pharmacological and Toxicological Methods, 2018, 94: 64-70.
KN-92 hydrochloride是KN-93的非活性类似物，可通过结构修饰转化为KN-93[1]。KN-92 hydrochloride具有较弱的离子电流抑制活性，能够抑制部分Kv通道[2]。KN-92 hydrochloride常作为阴性对照，用于阐明KN-93对哺乳动物卵细胞中CaMKII的抑制活性[3]。KN-92 hydrochloride可作为模型化合物，用于开发鉴定相关物质的新型HPLC-MS技术[4]。