(±)11(12)-EET-d11

(±)11(12)-EET-d₁₁ contains 11 deuterium atoms at the 16, 16', 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of (±)11(12)-DiHETrE by GC- or LC-mass spectrometry. (±)11(12)-EET is biosynthesized from arachidonic acid in rat and rabbit liver microsomes by CYP450.^1,2 (±)11(12)-EET has been shown, along with (±)8(9)-EET , to play a role in the recovery of depleted Ca²⁺ pools in cultured smooth muscle cells.³

1.Chacos, N., Falck, J.R., Wixtrom, C., et al.Novel epoxides formed during the liver cytochrome P-450 oxidation of arachidonic acidBiochem. Biophys. Res. Commun.104(3)916-922(1982) 2.Oliw, E.H., Guengerich, F.P., and Oates, J.A.Oxygenation of arachidonic acid by hepatic monooxygenases. Isolation and metabolism of four epoxide intermediatesJ. Biol. Chem.257(7)3771-3781(1982) 3.Graber, M.N., Alfonso, A., and Gill, D.L.Recovery of Ca2+ pools and growth in Ca2+ pool-depleted cells is mediated by specific epoxyeicosatrienoic acids derived from arachidonic acidJ. Biol. Chem.272(47)29546-29553(1997)