DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.
DDD107498 shows excellent activity against 3D7 parasites, with no toxic to human cells (MRC5 and Hep-G2 cells) at much higher concentrations.[1]
There is a lag of about 24-48 h, during which time the effects of DDD107498 are reversible following wash-out. Rapid killing occurred after parasites when exposed to DDD107498 for more than 48 h.[1]
[1] Beatriz Baraga?a, et al. Nature. 2015 Jun 18;522(7556):315-20.