GlpBio

GLP-2(1-33) (human)

目录号: GC16646纯度: >99.00%同义词: 人GLP-2肽,GLP-2 (human); Glucagon-like peptide 2 (human)
GLP-2(1-33) (human)是一种内分泌激素，由肠道L细胞在营养摄入后释放。
GLP-2(1-33) (human)
Cas No.: 223460-79-5
规格价格库存数量操作
500ug¥1,200.00现货
1
1mg¥1,995.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

GLP-2(1-33) (human) is an endocrine hormone that is released from the intestinal L-cell in response to nutrient ingestion. GLP-2 has many beneficial effects in the gut, including stimulation of intestinal epithelial cell proliferation, as well as enhancing the barrier function of the epithelium and improving both nutrient absorption and blood flow[1]. GLP-2 can be used in a broad variety of intestinal diseases characterized by intestinal damage and insufficiency[2].

GLP-2(1-33) (human) increase the expression of IGFBP-4 mRNA in the FRIC cultures by 40.8 ± 15.2% (P < 0.05)[1].

GLP-2(1-33) (human) (0.25mg/kg/time, 1 time, i.p.) can regulate the release of stored TG from the enterocyte[3]. GLP-2(1-33) (human) (400µg/kg, 2 times/day, 10 days, s.c.) significant increase (p-value: <0.001)) the intestinal growth in Transgenic female TgN (GCG.DTR) mice[4].

References:
[1] Austin K, Imam NA, Pintar JE, et al. IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine. Endocrinology. 2015 Feb 1;156(2):429-36.
[2] Wallis K, Walters JR, Forbes A. glucagon‐like peptide 2–current applications and future directions. Alimentary pharmacology & therapeutics. 2007 Feb;25(4):365-72.
[3] Hsieh J, Trajcevski KE, Farr SL, et al. Glucagon-like peptide 2 (GLP-2) stimulates postprandial chylomicron production and postabsorptive release of intestinal triglyceride storage pools via induction of nitric oxide signaling in male hamsters and mice. Endocrinology. 2015 Oct 1;156(10):3538-47.
[4] Gadgaard S, Windeløv JA, Schiellerup SP, et al. Long-acting agonists of human and rodent GLP-2 receptors for studies of the physiology and pharmacological potential of the GLP-2 system. Biomedicine & Pharmacotherapy. 2023 Apr 1;160:114383.

GLP-2(1-33) (human)是一种内分泌激素，由肠道L细胞在营养摄入后释放。GLP-2在肠道中具有许多有益作用，包括刺激肠上皮细胞增殖，增强上皮屏障功能，改善营养吸收和血流[1]。GLP-2可用于多种以肠道损伤和功能不全为特征的肠道疾病[2]。

GLP-2(1-33) (human)使FRIC培养物中IGFBP-4 mRNA的表达增加40.8 ± 15.2%（P < 0.05）[1]。

GLP-2(1-33) (human)（0.25mg/kg/次，1次，腹腔注射）可调节肠细胞释放储存的TG[3]。GLP-2(1-33) (human)（400µg/kg，2次/天，10天，皮下注射）显著增加（p值：<0.001）转基因雌性TgN（GCG.DTR）小鼠的肠道生长[4]。

实验参考方法 Experimental Reference Method

Cell experiment [1]:

Cell lines

 Fetal rat intestinal cells

Preparation Method

 Fetal rat intestinal cells (FRICs) are collected by enzymatical digestion of whole fetal rat intestines (mixed sex) and cultured overnight in DMEM containing 4.5g/L glucose, 5% fetal bovine serum, and 40U/mL penicillin and 40μg/mL streptomycin in 10cm plates. Cells are then treated with GLP-2(1-33) (human) (10-8M) or vehicle in low-glucose DMEM with 0.5% FBS for 0.5 to 24 hours.

Reaction Conditions

 10-8M, 0.5-24 hours

Applications

 GLP-2(1-33) (human) increase the expression of IGFBP-4 mRNA in the FRIC cultures by 40.8 ± 15.2% (P < 0.05).
Animal experiment [2]:

Animal models

 Hamsters that underwent intraduodenal catheterization

Preparation Method

 Hamsters that undergo intraduodenal catheterization (idc) are allowed 7 days of recovery before jugular vein catheterization. For postprandial experiments, conscious fasted (16h) hamsters receive a 75mmol/kg iv bolus of L-NAME. After 10 minutes, baseline blood sample is collected (time 0), followed by an oralgastric gavage of 3μL Ci [9,10-3H(N)] triolein in 200μL olive oil. At t=10 minutes, F-127 is given ip (1g/kg) to inhibit peripheral TG-rich lipoprotein (TRL) catabolism. At t=20 minutes, the hamsters receive ip injections of either PBS or 0.25mg/kg GLP-2(1-33) (human). Blood (400μL) is collected every 30 minutes for 2 hours. Blood is centrifuged at 6000rpm for 10 minutes at 4°C to isolate plasma. Radioactivity is assessed using a liquid scintillation counter.

Dosage form

 0.25mg/kg/time, 1 time, i.p.

Applications

 GLP-2(1-33) (human) can regulate the release of stored TG from the enterocyte.

References:
[1] Austin K, Imam NA, Pintar JE, et al. IGF binding protein-4 is required for the growth effects of glucagon-like peptide-2 in murine intestine. Endocrinology. 2015 Feb 1;156(2):429-36.
[2] Hsieh J, Trajcevski KE, Farr SL, et al. Glucagon-like peptide 2 (GLP-2) stimulates postprandial chylomicron production and postabsorptive release of intestinal triglyceride storage pools via induction of nitric oxide signaling in male hamsters and mice. Endocrinology. 2015 Oct 1;156(10):3538-47.

产品文档 Product Documents

Purity:>99.00%

化学性质Chemical Properties

CAS 号
223460-79-5
同义词
人GLP-2肽,GLP-2 (human); Glucagon-like peptide 2 (human)
分子式
C165H254N44O55S
分子量
3766.14 g/mol
溶解性
Soluble to 100 mg/ml in DMSO
保存条件
Desiccate at -20&deg;C,protect from light
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol