GlpBio

Serotonin Transporter

Serotonin Transporter(血清素转运蛋白)

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter 相关产品(57)

  • GC10126 structure
    GC10126Desipramine hydrochloride
    CAS: 58-28-6
    纯度: >99.50% / >99.00%

    Desipramine hydrochloride 是去甲肾上腺素转运蛋白 (NET)、5-HT 转运蛋白 (SERT) 和多巴胺转运蛋白 (DAT) 的抑制剂，Kis 分别为 4、61 和 78,720 nM。

  • GC10876 structure
    GC10876Vilazodone Hydrochloride
    CAS: 163521-08-2
    纯度: >98.00%

    An SSRI and a partial agonist of 5-HT 1A

  • GC10911 structure
    GC10911Venlafaxine hydrochloride
    CAS: 99300-78-4
    纯度: >99.50%

    Venlafaxine hydrochloride是一种具有口服活性的5-羟色胺和去甲肾上腺素再摄取抑制剂 （SNRIs; Serotonin-norepinephrine reuptake inhibitors），对配体与人NE和5-HT转运蛋白结合的Ki值分别为2480nM和82nM。

  • GC11570 structure
    GC11570Desvenlafaxine
    CAS: 93413-62-8

    An active metabolite of venlafaxine

  • GC11709 structure
    GC11709Fluoxetine HCl
    CAS: 56296-78-7
    纯度: >99.50%

    An Analytical Reference Material

  • GC11798 structure
    GC11798Cinchonidine
    CAS: 485-71-2
    纯度: >98.00%

    Cinchonidine (α-Quinidine) 是一种金鸡纳生物碱，存在于金鸡纳 (Cinchona officinalis) 和 Gongronema latifolium 中。

  • GC12055 structure
    GC12055Milnacipran HCl
    CAS: 101152-94-7
    纯度: >99.50%

    A serotonin and norepinephrine reuptake inhibitor

  • GC12720 structure
    GC12720Sertraline HCl
    CAS: 79559-97-0
    纯度: >99.50%

    A selective serotonin reuptake inhibitor

  • GC12885 structure
    GC12885Imipramine (hydrochloride)
    CAS: 113-52-0
    纯度: >99.50% / >98.00%

    A tricyclic antidepressant

  • GC13092 structure
    GC13092Fluvoxamine
    CAS: 54739-18-3

    Fluvoxamine是一种选择性血清素（5-HT）再摄取抑制剂（SSRI），具有抗抑郁活性。

  • GC13161 structure
    GC13161Escitalopram
    CAS: 128196-01-0

    Escitalopram是一种高选择性的5-羟色胺再摄取抑制剂（K i =0.89nM）。

  • GC13871 structure
    GC13871Duloxetine HCl
    CAS: 136434-34-9
    纯度: >99.50%

    A serotonin and norepinephrine reuptake inhibitor

  • GC14035 structure
    GC14035Citalopram hydrobromide
    CAS: 59729-32-7
    纯度: >99.50%

    A selective serotonin reuptake inhibitor

  • GC14262 structure
    GC14262Desvenlafaxine Succinate
    CAS: 386750-22-7
    纯度: >99.50%

    An active metabolite of venlafaxine

  • GC14330 structure
    GC14330Milnacipran
    CAS: 92623-85-3
    纯度: >98.00%

    A serotonin and norepinephrine reuptake inhibitor

  • GC14437 structure
    GC14437Vortioxetine (Lu AA21004) HBr
    CAS: 960203-27-4
    纯度: >99.50%

    A multimodal serotonergic agent

  • GC15013 structure
    GC15013Vilazodone
    CAS: 163521-12-8
    纯度: >99.00%

    Vilazodone (EMD 68843; SB 659746A) 是一种强效、选择性和口服活性的血清素再摄取抑制剂 (SSRI) 和部分 5-HT1A 受体激动剂。

  • GC15025 structure
    GC15025Fluvoxamine maleate
    CAS: 61718-82-9
    纯度: >99.50%

    A selective serotonin reuptake inhibitor

  • GC15107 structure
    GC15107Clomipramine HCl
    CAS: 17321-77-6
    纯度: >99.00%

    A tricyclic antidepressant

  • GC16312 structure
    GC16312Vortioxetine
    CAS: 508233-74-7
    纯度: >99.50%

    Vortioxetine是一种多模式抗抑郁药，对重组人5-HT1A（K i =15nM）、5-HT1B（K i =33nM）、5-HT3A（K i =3.7nM）、5-HT7（K i =19nM）、noradrenergic β1 receptor（K i =46nM）以及SERT（K i =1.6nM）具有高亲和力。

  • GC16797 structure
    GC16797Escitalopram Oxalate
    CAS: 219861-08-2
    纯度: >99.50%

    Escitalopram Oxalate是一种高选择性的5-羟色胺再摄取抑制剂（K i =0.89nM）。

  • GC17061 structure
    GC17061Dapoxetine HCl
    CAS: 129938-20-1
    纯度: >99.50%

    An Analytical Reference Standard

  • GC17229 structure
    GC17229Paroxetine HCl
    CAS: 78246-49-8
    纯度: >99.50% / >99.00%

    A selective serotonin reuptake inhibitor

  • GC18497 structure
    GC18497Dapoxetine
    CAS: 119356-77-3
    纯度: >99.50%

    Dapoxetine (LY-210448) 是一种具有口服活性的选择性血清素再摄取 (serotonin reuptake) 抑制剂 (SSRI)。Dapoxetine 可用于早泄 (PE) 的相关研究。