GlpBio

Serotonin Transporter

Serotonin Transporter(血清素转运蛋白)

Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Serotonin Transporter 相关产品(57)

  • GC19117 structure
    GC19117Dasotraline
    CAS: 675126-05-3

    Dasotraline 是一种三重再摄取抑制剂，可阻断多巴胺、去甲肾上腺素和血清素转运蛋白，IC50 值分别为 4、6 和 11 nM。

  • GC19118 structure
    GC19118Dasotraline hydrochloride
    CAS: 675126-08-6
    纯度: >99.50%

    Dasotraline hydrochloride (SEP-225289 hydrochloride) 是一种三重再摄取抑制剂，可阻断多巴胺、去甲肾上腺素和血清素转运蛋白，IC50 值分别为 4、6 和 11 nM。

  • GC25708 structure
    GC25708Paroxetine mesylate
    CAS: 217797-14-3

    Paroxetine Mesylate(BRL-29060A mesylate,FG-7051 mesylate) is the mesylate salt form of paroxetine, a phenylpiperidine derivative and a selective serotonin reuptake inhibitor (SSRI) with antidepressant and anxiolytic properties.

  • GC30375 structure
    GC30375Clomipramine D3
    CAS: 136765-29-2

    An Analytical Reference Standard

  • GC30772 structure
    GC30772Dopamine serotonin antagonist-1
    CAS: 1977-07-7

    Deschloroclozapine, a metabolite of Clozapine, is a highly potent muscarinic DREADDs (muscarinic Designer Receptors Exclusively Activated by Designer Drugs) agonist, and binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM, respectively.

  • GC30981 structure
    GC30981Amitifadine hydrochloride (DOV-21947 hydrochloride)
    CAS: 410074-74-7
    纯度: >99.50%

    Amitifadine hydrochloride (DOV-21947 hydrochloride) 是一种 5-羟色胺-去甲肾上腺素-多巴胺再摄取抑制剂 (SNDRI)，在 HEK 293 细胞中对 5-羟色胺、去甲肾上腺素和多巴胺的 IC50 分别为 12、23、96 nM。

  • GC30992 structure
    GC30992Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate)
    CAS: 110429-35-1

    Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.

  • GC31020 structure
    GC31020SPD-473 citrate
    CAS: 161190-26-7

    SPD-473citrate是5-HT/多巴胺/去甲肾上腺素再摄取抑制剂。

  • GC31029 structure
    GC31029Nitroxazepine (CIBA 2330Go)
    CAS: 47439-36-1

    Nitroxazepine (CIBA 2330Go) 是一种用于抑郁症研究的三环类抗抑郁药 (TCA)。

  • GC31041 structure
    GC31041Wf-516
    CAS: 310392-94-0

    Wf-516是一种5-HTreuptake的抑制剂，同时为5-HT1A和5-HT2A受体拮抗剂，对人体5-HT1A和5-HT2A受体的Ki值分别为5nM和40nM，具有抗抑郁作用。

  • GC31064 structure
    GC31064Duloxetine ((S)-Duloxetine)
    CAS: 116539-59-4
    纯度: >98.00% / >99.50%

    Duloxetine (LY-248686) is a potent inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and noradrenaline (NE) uptake in vitro and in vivo and is 3- to 5-times more effective at inhibiting 5-HT uptake.

  • GC31175 structure
    GC31175Centanafadine hydrochloride (EB-1020 (hydrochloride))
    CAS: 923981-14-0
    纯度: >99.50%

    Centanafadine (hydrochloride) 是去甲肾上腺素 (NE)/多巴胺 (DA) 转运蛋白双重抑制剂，也抑制血清素转运蛋白，对人 NE、DA 和血清素转运蛋白的 IC50 分别为 6 nM、38 nM 和 83 nM。

  • GC31283 structure
    GC31283Centanafadine (EB-1020)
    CAS: 924012-43-1

    Centanafadine (EB-1020) 是双重去甲肾上腺素 (NE)/多巴胺 (DA) 转运蛋白抑制剂，也抑制血清素转运蛋白，对人 NE、DA 和血清素转运蛋白的 IC50 分别为 6 nM、38 nM 和 83 nM。

  • GC33715 structure
    GC33715Fluoxetine (LY-110140)
    CAS: 54910-89-3
    纯度: >98.00%

    氟西汀Fluoxetine (LY-110140)是一种具有口服活性的选择性5-羟色胺再摄取抑制剂（SSRI），常用于治疗抑郁症、强迫症、恐慌症等多种精神疾病。

  • GC34559 structure
    GC34559DOV-216,303 Free Base
    CAS: 66504-40-3
    纯度: >98.00%

    DOV-216,303(FreeBase)是有效的5-羟色胺、去甲肾上腺素、多巴胺再摄取的三重抑制剂，其对hSERT、hNET和hDAT的IC50值分别为14nM，20nM和78nM。在嗅球切除大鼠模型中，可增加前额皮质中单胺的释放及具有抗抑郁的作用。

  • GC34575 structure
    GC34575Eplivanserin mixture
    CAS: 130581-13-4
    纯度: >99.50%

    Eplivanserinmixture是一种选择性的血清素再摄取抑制剂，是5-HT2A受体的拮抗剂。化合物信息来自专利WO2005/002578A1。

  • GC35443 structure
    GC35443Azaphen
    CAS: 24853-80-3

    Pipofezine(Azafen,Azaphen)是5-羟色胺重吸收抑制剂。

  • GC35444 structure
    GC35444Azaphen dihydrochloride monohydrate
    CAS: 63302-99-8
    纯度: >99.50%

    Pipofezine(Azafen，Azaphen)是5-羟色胺重吸收抑制剂。

  • GC37906 structure
    GC37906Vilazodone D8
    CAS: 1794789-93-7

    An internal standard for the quantification of vilazodone

  • GC44057 structure
    GC44057Levomilnacipran (hydrochloride)
    CAS: 175131-60-9
    纯度: >98.00%

    A serotonin and norepinephrine reuptake inhibitor

  • GC47101 structure
    GC47101Clomipramine-d3 (hydrochloride)
    CAS: 1398065-86-5
    纯度: >99.00% / >99.50%

    An Analytical Reference Standard

  • GC47277 structure
    GC47277Duloxetine-d3 (hydrochloride)
    CAS: 1188266-11-6
    纯度: >99.00%

    An internal standard for the quantification of duloxetine

  • GC48255 structure
    GC48255Vortioxetine-d8
    CAS: 2140316-62-5
    纯度: >99.00%

    An internal standard for the quantification of vortioxetine

  • GC60394 structure
    GC60394(±)-Duloxetine hydrochloride
    CAS: 947316-47-4
    纯度: >99.50%

    (±)-Duloxetine((Rac)-Duloxetine)hydrochloride是Duloxetinehydrochloride的外消旋体。Duloxetinehydrochloride是一种5-羟色胺去甲肾上腺素再摄取抑制剂，可用于糖尿病性神经痛和纤维肌痛以及抑郁症的研究。