C3a Receptor Agonist is a selective and specific agonist for the complement 3a receptor (C3aR)[1]. C3aR is a G protein-coupled receptor that is mainly expressed on immune cells (such as monocytes, macrophages, and dendritic cells) and non-immune cells (such as endothelial cells and neurons)[2]. After being activated, C3aR can mediate downstream signal transduction, including ERK1/2 phosphorylation and intracellular calcium ion mobilization, thereby triggering a series of biological effects, such as cell chemotaxis, release of inflammatory factors, cell adhesion and increased vascular permeability[3]. C3a Receptor Agonist can be used in the research of disease mechanisms related to the complement system.
References:
[1] Klos A, Wende E, Wareham KJ, Monk PN. International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors. Pharmacol Rev. 2013;65(1):500-543.
[2] Kim BJ, Mastellos DC, Li Y, Dunaief JL, Lambris JD. Targeting complement components C3 and C5 for the retina: Key concepts and lingering questions. Prog Retin Eye Res. 2021;83:100936.
[3] Klos A, Tenner AJ, Johswich KO, Ager RR, Reis ES, Köhl J. The role of the anaphylatoxins in health and disease. Mol Immunol. 2009;46(14):2753-2766.
C3a Receptor Agonist是一种选择性的补体3a受体（C3aR）特异性激动剂[1]。C3aR是一种G蛋白偶联受体，主要表达于免疫细胞（如单核细胞、巨噬细胞、树突状细胞）和非免疫细胞（如内皮细胞、神经元）上[2]。C3aR被激活后可介导下游信号传导，包括ERK1/2磷酸化和细胞内钙离子动员，从而引发一系列生物学效应，如细胞趋化、炎症因子释放、细胞黏附和血管通透性增加[3]。C3a Receptor Agonist可用于补体系统相关疾病机制研究。