Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC44015 KT109 N2 Regioisomer An N2-carbamoylated regioisomer of KT109
GC47532 KUS121 A VCP modulator
GC52328 KYL (trifluoroacetate salt)

KYL Peptide
An EphA4 inhibitor
GC63035 Kynuramine dihydrochloride Kynuramine 是一种内源性胺，是血浆胺氧化酶 (amine oxidase) 的荧光底物和探针。
GC36411 Kynurenic acid sodium Kynurenic acid sodium 是一种内源性色氨酸代谢物，是针对靶点 NMDA, glutamate, α7 nicotinic acetylcholine receptor 的光谱性拮抗剂。Kynurenic acid sodium 也是 GPR35/CXCR8 的激动剂。
GC26184 Kynurenic acid-d5

犬尿喹啉酸 d5; Quinurenic acid-d5

Kynurenic acid-d₅ 是 Kynurenic acid 的氘代物。
GC14620 L 760735 L 760735 是一种高亲和力、选择性和口服活性的 NK1 受体拮抗剂，对人 NK1 受体的 IC50 为 0.19 nM。
GC20029 L(-)-Borneol A bicyclic monoterpene
GC49436 L-3-n-Butylphthalide

(-)-3-Butylphthalide, levo-3-n-Butylphthalide, (S)-(-)-3-Butylphthalide, L-NBP
A phthalide with antiplatelet and neuroprotective activities
GC70264 L-365260 hemihydrate L-365260 hemihydrate是非肽胃泌素和脑胆囊收缩素受体(CCK-B)的口服选择性活性拮抗剂，Kis分别为1.9 nM和2.0 nM。
GC17350 L-655,708 A ligand for α₅ subunit-containing GABA_A receptors with nootropic activity
GC14810 L-701,324

7-氯-4-羟基-3-(3-苯氧基)苯基-2(1H)-喹啉
An NMDA receptor antagonist
GC72876 L-703606 oxalate hydrate L-703606 oxalate hydrate是一种有效的，选择性的NK1受体拮抗剂。
GC18128 L-732,138 An NK₁ receptor antagonist
GC13599 L-733,060 hydrochloride L-733,060 hydrochloride 是一种有效的速激肽 NK1 受体拮抗剂。
GC15619 L-741,626 A dopamine D₂ receptor antagonist
GC13036 L-741,742 hydrochloride highly potent and selective D4 dopamine receptor antagonist
GC14569 L-745,870 trihydrochloride L-745,870 trihydrochloride 是一种有效的、选择性的、脑渗透性和口服活性的多巴胺 D4 受体拮抗剂，Ki 为 0.43 nM。
GC38805 L-745870

三氢氯酸L-745,870
L-745870 is a high-affinity, selective and orally active antagonist of human dopamine D4 receptor with Ki of 0.43 nM. L-745870 considerably weaker D2 and D3 receptors affinity with Ki of 960 nM and 2300 nM, respectively. L-745870 has excellent brain penetration.
GC38806 L-745870 hydrochloride L-745870 hydrochloride 是一种高亲和力，选择性和口服活性的人多巴胺 D4 受体拮抗剂，Ki 为 0.43 nM，而对 D2 (Ki 为 960 nM) 和 D3 (Ki 为 2300 nM) 受体的亲和力相对较弱。L-745870 hydrochloride 具有出色的大脑渗透能力。
GC13314 L-Acetylcarnitine (hydrochloride)

乙酰左旋肉碱,Acetyl-L-Carnitine,ALCAR
A mitochondrial metabolite
GC40951 L-Allylglycine

(S)-(-)-2-氨基-4-戊烯酸,L-Allylglycine
A GAD inhibitor
GC17932 L-AP4

L(+)-2-氨基-4-膦酰基丁酸,L-APB
A selective Group III metabotropic glutamate receptor agonist
GC15136 L-AP6

DL-2-氨基-6-膦酰己酸
selective agonist for 'quis'-sensitized site
GC52310 L-Arginine-13C6 (hydrochloride)

L-(+)-Arginine-13C6
An internal standard for the quantification of L-arginine
GC49374 L-Arginine-d7 (hydrochloride)

L-精氨酸D7盐酸盐,(S)-(+)-Arginine-d7 hydrochloride
An internal standard for the quantification of L-arginine
GC12224 L-BMAA hydrochloride

L-BMAA盐酸盐,BMAA hydrochloride
A neurotoxic non-proteinogenic amino acid
GC13881 L-CCG-l

(2S,1'S,2'S)-2-(羧基环丙基)甘氨酸

group II metabotropic glutamate receptor agonist
GC30862 L-Cycloserine ((S)-4-Amino-3-isoxazolidone)

环丝氨酸,(S)-Cycloserine; (S)-4-Amino-3-isoxazolidone
An inhibitor of sphingolipid synthesis and aminotransferases
GC52283 L-Cysteine-15N-d3

L-Cys-15N-d3, L-(+)-Cysteine-15N-d3, (R)-Cysteine-15N-d3
An internal standard for the quantification of L-cysteine
GC25566 L-DAB HBR

L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide
L-DAB HBR (L-Dab Hydrobromide, L-2,4-Diaminobutyric acid hydrobromide) is an inhibitor of GABA (Gamma-aminobutyric acid) transaminase with IC50 of >500 μM
GC14281 L-DOPA methyl ester (hydrochloride)

盐酸左旋多巴甲酯,3,4-Dihydroxyphenylalanine methyl ester,LDME,Levodopa methyl ester,ST 41769
A dopamine precursor
GC74238 L-DOPA-13C

左旋多巴-13C
L-DOPA-13C是13C标记的L-DOPA。
GC47550 L-DOPA-d3

左旋多巴D3
An internal standard for the quantification of L-DOPA
GA10750 L-Glutamic acid

L-谷氨酸
L-Glutamic acid是哺乳动物中枢神经系统（CNS）中的主要兴奋性神经递质。L-Glutamic acid有两种主要类型的受体：离子型(NMDA-, AMPA- and kainate-selective iGluRs)和代谢型谷氨酸受体。L-Glutamic acid对突触后N-甲基-D-天冬氨酸受体的激动作用产生兴奋毒性，从而导致神经退行性病变。
GC47563 L-Glutamic Acid (ammonium salt)

谷氨酸一铵
An excitatory neurotransmitter
GC30788 L-Glutamic acid monosodium salt (Monosodium glutamate)

谷氨酸单钠盐
L-Glutamic acid monosodium salt is the sodium salt of glutamic acid, found naturally in tomatoes, cheese and other foods. L-Glutamic acid monosodium salt acts as an excitatory transmitter and an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). (S)-Glutamic acid shows a direct activating effect on the release of DA from dopaminergic terminals.
GC64352 L-Glutamic acid-15N

L-谷氨酸 15N
L-Glutamic acid-15N 是一种 15N 标记的 L-Glutamic acid。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。
GC65095 L-Glutamic acid-d5

L-谷氨酸 d5
L-Glutamic acid-d5 是 L-Glutamic acid 的氘代物。L-Glutamic acid 作为一种兴奋性氨基酸神经递质，为谷氨酸盐受体所有亚型(代谢型红藻氨酸、NMDA 和 AMPA)的激动剂。对 DA 从多巴胺能神经末梢释放的过程有激动作用。
GC49377 L-Glutamine-d5

L-谷氨酰胺-2,3,3,4,4-D5,L-Glutamic acid 5-amide-d5
An internal standard for the quantification of L-glutamine
GC66843 L-Homocysteic acid

L-HCA
L-Homocysteic acid (L-HCA) 是一种内源性兴奋性氨基酸，可作为 NMDA 受体激动剂 (EC50: 14 μM)。L-Homocysteic acid 具有神经毒性，可用于神经系统疾病的研究。
GC39130 L-Hyoscyamine sulfate

L-莨菪碱硫酸盐; Daturine sulfate
L-Hyoscyamine sulfate (Daturine sulfate) 是一种莨菪烷生物碱，是茄科某些植物的次生代谢物。体外实验表明它是一种 mAChR 受体的拮抗剂。
GC65504 L-Hyoscyamine-d3

Daturine-d3
L-Hyoscyamine-d3 (Daturine-d3) 是 L-Hyoscyamine 的氘代物。L-Hyscyamine (Daturine) 是一种天然的植物托烷生物碱，是有效的，竞争性的毒蕈碱受体 (MR) 拮抗剂。L-Hyscyamine 是 Atropine 的左旋异构体。
GC52323 L-Isoleucine-13C6

L-(+)-Isoleucine-13C6
An internal standard for the quantification of L-isoleucine
GC49505 L-Kynurenine-d4

3-anthraniloyl-Alanine-d4, L-KYN-d4
L-Kynurenine-d4是一种芳烃受体激动剂。
GC49382 L-Lysine-d3 (hydrochloride)

L-赖氨酸 d3 (盐酸)
An internal standard for the quantification of L-lysine
GC49782 L-Phenylalanine-13C6

L-苯丙氨酸-13C6,(S)-2-Amino-3-phenylpropionic acid-13C6
An internal standard for the quantification of phenylalanine
GC64148 L-Phenylalanine-15N

L-苯丙氨酸-15N,(S)-2-Amino-3-phenylpropionic acid-15N
L-Phenylalanine-15N ((S)-2-Amino-3-phenylpropionic acid-15N) 是一种 15N 标记的 L-Phenylalanine。L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2+ 通道拮抗剂，Ki 为 980 nM。L-Pheny
GC65050 L-Phenylalanine-d2

L-苯丙氨酸-Β,Β-D2,(S)-2-Amino-3-phenylpropionic acid-d2
L-Phenylalanine-d2 ((S)-2-Amino-3-phenylpropionic acid-d2) 是 L-Phenylalanine 的氘代物。L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2+ 通道拮抗剂，Ki 为 980 nM。L-Phenylalanine 是 NMDARs (KB 573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine 广泛用于食品香料和药品的生产中。
GC63982 L-Phenylalanine-d5

L-苯丙氨酸-d5
L-Phenylalanine-d5 是 L-Phenylalanine 的氘代物。L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) 是分离自大肠杆菌的必需氨基酸。L-Phenylalanine 是一种电压依赖性 α2δ 亚基 Ca2+ 通道拮抗剂，Ki 为 980 nM。L-Phenylalanine 是 NMDARs (KB 573 μM) 和非 NMDARs 的甘氨酸和谷氨酸结合位点的竞争性拮抗剂。L-Phenylalanine 广泛用于食品香料和药品的生产中。