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Home >> Signaling Pathways >> Neuroscience >> Alzheimer

Alzheimer(阿尔茨海默病)

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

Products for  Alzheimer

  1. Cat.No. 产品名称 Information
  2. GC11965 (±)-Huperzine A

    (±)-石杉碱甲

     A neuroprotective AChE inhibitor
  3. GC26199 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine

    1-十七碳酰-甘油-3-磷酰胆碱
  4. GC46451 16F16 A PDI inhibitor
  5. GC65195 2-O-Acetyl-20-hydroxyecdysone

    2-乙酰基Β-蜕皮甾酮,20-Hydroxyeedysone 2-acetate

     An ecdysone steroid hormone
  6. GC18817 3β-hydroxy-5-Cholestenoic Acid

    3β-hydroxy-5-CA, Cholesterol-26-carboxylic Acid

     An active cholesterol metabolite
  7. GC40053 5α,6α-epoxy Cholestanol

    胆固醇-5Α,6Α-环氧化物,NSC 18176

     5α,6α-epoxy Cholestanol 是一种胆固醇衍生物，可以通过线粒体中的细胞色素P450酶系催化生成或是在脂质过氧化过程中诱导生成，可调节胆汁酸的生物合成、诱导肿瘤细胞的分化和死亡。
  8. GC52172 5-hydroxy Indole-3-acetic Acid-d6

    5-HIAA-d6, 5-Hydroxyindoleacetic Acid-d6, 5-hydroxy IAA-d6

     An internal standard for the quantification of 5-hydroxy indole-3-acetic acid
  9. GC46720 6,9-Dichloro-1,2,3,4-tetrahydroacridine

    NSC 1227

     A synthetic intermediate in the synthesis of AChE inhibitors
  10. GC42584 6-O-desmethyl Donepezil

    6-O-去甲基多奈哌齐

     An active metabolite of donepezil
  11. GC40587 8,12-iso-iPF2α-VI

    8,12-iso-Isoprostane-F2α-VI, 12-iso-5,6E,14Z-PGF2α, 125,6E,14ZProstaglandin F2α

     An isoprostane used as a biomarker for oxidative stress
  12. GC45378 Alaproclate (hydrochloride)

    阿拉丙酯盐酸盐

     An SSRI
  13. GC40024 Altenusin

    细格菌素,Alutenusin

     A fungal metabolite with diverse biological activities
  14. GC42794 Amylin (8-37) (human) (trifluoroacetate salt)

    IAPP (8-37) (human), Islet Amyloid Polypeptide (8-37) (human)

     A peptide fragment of amylin
  15. GC42795 Amylin (human) (amidated) (trifluoroacetate salt)

    IAPP (human) (amidated), Islet Amyloid Polypeptide (human) (amidated)

     A peptide hormone
  16. GC42796 Amylin (human) (trifluoroacetate salt)

    IAPP (human), Islet Amyloid Polypeptide (human)

     An antidiabetic peptide that forms amyloid fibrils
  17. GP10099 amyloid A protein fragment [Homo sapiens]

    H2N-Ala-Gly-Leu-Pro-Glu-Lys-Tyr-OH

    Apolipoproteins related to HDL in plasma
  18. GP10118 Amyloid Beta-Peptide (1-40) (human)

    BETA淀粉样蛋白片段1-40,Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val

    Amyloid Beta-Peptide (1-40) (human)是老年斑淀粉样蛋白的主要成分，作为生理性肽段存在于脑组织、脑脊液（CSF）及血浆中。
  19. GP10049 Amyloid Beta-Peptide (12-28) (human)

    淀粉-Β-蛋白片段12-28,Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys

    Amyloid Beta-Peptide (12-28)（人）是 Amyloid Beta 蛋白 (1-42) (Aβ (1-42)) 的肽片段。
  20. GP10082 Amyloid Beta-peptide (25-35) (human)

    BETA-淀粉样蛋白片断25-35,Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met

    淀粉样蛋白β肽(Aβ) (25-35)(human)是阿尔茨海默病淀粉样蛋白β肽的片段，具有神经毒性作用。
  21. GP10046 Amyloid Precursor C-Terminal Peptide

    H2N-Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn-OH

    For beta amyloid generation
  22. GP10057 Amyloid β-Peptide (10-20) (human)

    Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe

    Amyloid β-Peptide (10-20) (human) 是 Amyloid-&#946 的片段；肽，可用于神经系统疾病的研究。
  23. GP10094 Amyloid β-peptide (10-35), amide

    H2N-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-NH2

    Truncated peptide model
  24. GP10097 Amyloid β-Protein (1-15)

    H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-OH

    淀粉样蛋白 β-蛋白 (1-15) 是 β-淀粉样蛋白肽的片段。
  25. GC46851 Amyloid-β (1-42) Peptide (trifluoroacetate salt)

    Aβ (1-42), Aβ42

     A 42-amino acid protein fragment of amyloid-β
  26. GC42801 Amyloid-β (1-8) Peptide

    Aβ (1-8)

     A wild-type control for amyloid-β (1-8, A2V) peptide
  27. GC42802 Amyloid-β (1-8, A2V) Peptide

    Aβ (1-8, A2V), Aβ (1-8) mutant, Amyloid-β (1-8) dominant negative

     A truncated form of Aβ containing the A2V mutation
  28. GC42803 Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)

    Aβ (25-35)

     An 11-residue amyloid-β protein fragment
  29. GP10083 Beta-Amyloid (1-11)

    H2N-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-OH

    Beta-Amyloid (1-11) 是 Amyloid-&#946 的片段；肽，可用于神经系统疾病的研究。
  30. GP10101 Beta-Sheet Breaker Peptide iAβ5

    H2N-Leu-Pro-Phe-Phe-Asp-OH

    Peptide which can inhibit amyloidogenesis
  31. GC42937 Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

    Biotin-Aβ (1-42), Biotin-Aβ42

     An affinity probe for Aβ42 binding partners
  32. GC46992 C18 Ganglioside GM1-d3 (d18:1/18:0-d3) (ammonium salt)

    N-omega-CD3-Octadecanoyl monosialoganglioside GM1-d3, N-CD3-Stearoyl-GM, C18 GM1-d3, GM1 (18:1/18:0-d3), GM1 (d18:1/C18:0)-d3, Monosialoganglioside GM1-d3, N-Stearoyl Monosialoganglioside GM1-d3

     A neuropeptide with diverse biological activities
  33. GC46997 C22 Galactosylceramide (d18:1/22:0)

    N-Docosanoyl-β-D-Galactosylceramide, Galactosylceramide (d18:1/22:0), GalCer(d18:1/22:0)

     A sphingolipid
  34. GC46998 C22 Galactosylceramide-d4 (d18:1/22:0-d4)

    Galactosylceramide-d4 (d18:1/22:0-d4), N-Docosanoyl-β-D-Galactosylceramide-d4, GalCer(d18:1/22:0-d4)

     A neuropeptide with diverse biological activities
  35. GC91899 Carmustine-d8

    BCNU-d8; bis-Chloroethylnitrosourea-d8

     Carmustine-d8旨在用作气相色谱或液相色谱-质谱定量卡莫司汀的内标。
  36. GC43274 Citromycetin

    柠檬菌素

     A fungal metabolite
  37. GP10010 COG 133

    Leu-Arg-Val-Arg-Leu-Ala-Ser-His-Leu-Arg-Lys-Leu-Arg-Lys-Arg-Leu-Leu

    A peptide fragment of ApoE and an α7 nAChR antagonist
  38. GC43322 CRANAD 28 A fluorescent affinity probe for amyloid-β
  39. GC49557 Cu-GTSM

    CuII(gtsm), copper-GTSM

     A copper-containing compound with diverse biological activities
  40. GC12942 DAPT (GSI-IX)

    gamma-Secretase Inhibitor IX, DAPT, GSI-IX

     DAPT (GSI-IX) 是一种具有口服活性的 γ-分泌酶抑制剂，对人原代神经元培养物中产生的总淀粉样蛋白-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。
  41. GC49913 Davunetide (acetate)

    AL-108, NAP, NAPVSIPQ

     A neuroprotective ADNP-derived peptide
  42. GC41151 Decursinol angelate Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.
  43. GC45765 Deferiprone-d3

    去铁酮 d3

     An internal standard for the quantification of deferiprone
  44. GC47186 Deoxy Donepezil (hydrochloride)

    1-苄基-4-((5,6-二甲氧基-2,3-二氢-1H-茚-2-基)甲基)哌啶盐酸盐

     A potential impurity found in bulk preparations of donepezil
  45. GC47196 Desloratadine-d4

    Sch34117-d4

     An internal standard for the quantification of desloratadine
  46. GC46134 Dityrosine (hydrochloride)

    Bityrosine, o,o-Ditryosine

     A neuropeptide with diverse biological activities
  47. GC43494 DL-threo-PDMP (hydrochloride) An inhibitor of sphingolipid biosynthesis
  48. GC47263 Donecopride (fumarate hydrate)

    MR31147

     A 5-HT4 receptor partial agonist and AChE inhibitor
  49. GC40018 Donepezil N-oxide

    多奈哌齐N氧化物

     An active metabolite of donepezil
  50. GC47264 Donepezil-d4 (hydrochloride)

    多奈哌齐-D4,E2020-d4

     An internal standard for the quantification of donepezil
  51. GC43700 FSB A fluorescent probe

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