Alzheimer
Alzheimer(阿尔茨海默病)
Alzheimer
Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more
Alzheimer 相关产品(103)
- GC12942DAPT (GSI-IX)CAS: 208255-80-5纯度: >98.00%
DAPT (GSI-IX) 是一种具有口服活性的 γ-分泌酶抑制剂，对人原代神经元培养物中产生的总淀粉样蛋白-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。
- GC19799Selegiline hydrochlorideCAS: 14611-52-0纯度: >99.00% / >98.00%
Selegiline hydrochloride一种选择性单胺氧化酶B抑制剂，用于治疗帕金森病和重度抑郁症。
- GC20007Ginsenoside CKCAS: 39262-14-1纯度: >98.00%
Ginsenoside CK，一种由主要人参皂苷化合物转化而来的次级人参皂苷，比其母体人参皂苷具有更高的生物利用度和溶解性，具有极其重要的意义。
- GC261991-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholineCAS: 50930-23-9纯度: >99.00% / >98.00%
1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine是血液中存在的一种内源性代谢物，可作为小鼠模型抑郁症的诊断生物标志物。
- GC400535α,6α-epoxy CholestanolCAS: 1250-95-9纯度: >95.00%
5α,6α-epoxy Cholestanol 是一种胆固醇衍生物，可以通过线粒体中的细胞色素P450酶系催化生成或是在脂质过氧化过程中诱导生成，可调节胆汁酸的生物合成、诱导肿瘤细胞的分化和死亡。
- GC40078Memantine-d6 (hydrochloride)CAS: 1189713-18-5纯度: >99.00%
An internal standard for the quantification of memantine
- GC40114Histone H3K4Me3 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
Histone H3K4Me3 (1-10) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence.
- GC405878,12-iso-iPF2α-VICAS: 1445349-99-4纯度: >95.00%
An isoprostane used as a biomarker for oxidative stress
- GC41151Decursinol angelateCAS: 130848-06-5纯度: >98.00%
Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.
- GC42796Amylin (human) (trifluoroacetate salt)纯度: >95.00%
An antidiabetic peptide that forms amyloid fibrils
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC11965 | (±)-Huperzine A | 120786-18-7 | >98.00% | |
A neuroprotective AChE inhibitor | ||||
| GC12096 | Semagacestat (LY450139) | 425386-60-3 | >99.50% | |
A pan γ-secretase inhibitor | ||||
| GC12942 | DAPT (GSI-IX) | 208255-80-5 | >98.00% | |
DAPT (GSI-IX) 是一种具有口服活性的 γ-分泌酶抑制剂，对人原代神经元培养物中产生的总淀粉样蛋白-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。 | ||||
| GC18483 | RU-505 | 1314206-29-5 | - | |
An inhibitor of the Aβ and fibrinogen interaction | ||||
| GC18568 | JNJ-40418677 | 1146594-87-7 | - | |
A modulator of γ-secretase | ||||
| GC18817 | 3β-hydroxy-5-Cholestenoic Acid | 6561-58-6 | - | |
An active cholesterol metabolite | ||||
| GC19221 | Leucomethylene blue Mesylate | 1236208-20-0 | >98.00% | |
An inhibitor of tau aggregation | ||||
| GC19799 | Selegiline hydrochloride | 14611-52-0 | >99.00% / >98.00% | |
Selegiline hydrochloride一种选择性单胺氧化酶B抑制剂，用于治疗帕金森病和重度抑郁症。 | ||||
| GC20007 | Ginsenoside CK | 39262-14-1 | >98.00% | |
Ginsenoside CK，一种由主要人参皂苷化合物转化而来的次级人参皂苷，比其母体人参皂苷具有更高的生物利用度和溶解性，具有极其重要的意义。 | ||||
| GC26199 | 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine | 50930-23-9 | >99.00% / >98.00% | |
1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine是血液中存在的一种内源性代谢物，可作为小鼠模型抑郁症的诊断生物标志物。 | ||||
| GC39419 | PBD-150 | 790663-33-1 | >98.00% | |
A glutaminyl cyclase inhibitor | ||||
| GC40018 | Donepezil N-oxide | 120013-84-5 | >98.00% | |
An active metabolite of donepezil | ||||
| GC40024 | Altenusin | 31186-12-6 | >98.00% | |
A fungal metabolite with diverse biological activities | ||||
| GC40053 | 5α,6α-epoxy Cholestanol | 1250-95-9 | >95.00% | |
5α,6α-epoxy Cholestanol 是一种胆固醇衍生物，可以通过线粒体中的细胞色素P450酶系催化生成或是在脂质过氧化过程中诱导生成，可调节胆汁酸的生物合成、诱导肿瘤细胞的分化和死亡。 | ||||
| GC40068 | Setosusin | 182926-45-0 | >99.00% | |
A fungal metabolite | ||||
| GC40078 | Memantine-d6 (hydrochloride) | 1189713-18-5 | >99.00% | |
An internal standard for the quantification of memantine | ||||
| GC40114 | Histone H3K4Me3 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
Histone H3K4Me3 (1-10) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence. | ||||
| GC40587 | 8,12-iso-iPF2α-VI | 1445349-99-4 | >95.00% | |
An isoprostane used as a biomarker for oxidative stress | ||||
| GC41151 | Decursinol angelate | 130848-06-5 | >98.00% | |
Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A. | ||||
| GC42584 | 6-O-desmethyl Donepezil | 120013-56-1 | >98.00% | |
An active metabolite of donepezil | ||||
| GC42794 | Amylin (8-37) (human) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of amylin | ||||
| GC42795 | Amylin (human) (amidated) (trifluoroacetate salt) | - | >95.00% | |
A peptide hormone | ||||
| GC42796 | Amylin (human) (trifluoroacetate salt) | - | >95.00% | |
An antidiabetic peptide that forms amyloid fibrils | ||||
| GC42801 | Amyloid-β (1-8) Peptide | - | >98.00% | |
A wild-type control for amyloid-β (1-8, A2V) peptide | ||||