1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine is an endogenous metabolite present in the blood and can be used as a diagnostic biomarker for depression in mouse models [1]. 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine alters the rigidity of the cell membrane and can interfere with tumor metastasis[2]. 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine is widely used as an internal standard to develop electrospray mass spectrometry for the identification of related compounds [3].
In vivo, 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine treatment via a single intravenous injection at a dose of 5mg/kg for 2 hours significantly reduced the interaction between TRPV4 and KCa3.1 channels in the coronary artery endothelial cells (CAECs) of mice and decreased the vascular dilation of the arterial segments[4].
References:
[1] Wang Y, Chen X, Chen Z, et al. Disturbances of phosphatidylcholines metabolism in major depressive disorder[J]. CNS spectrums, 2023, 28(5): 637-645.
[2] 1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine alters the rigidity of the cell membrane and can interfere with tumor metastasis.
[3] Rush M D, van Breemen R B. Role of ammonium in the ionization of phosphatidylcholines during electrospray mass spectrometry[J]. Rapid Communications in Mass Spectrometry, 2017, 31(3): 264-268.
[4] Mao A, He D, Zhang K, et al. Functional role of coupling the endothelial TRPV4 and KCa3. 1 channels in regulating coronary vascular tone[J]. British Journal of Pharmacology, 2023, 180(17): 2266-2279.
1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine是血液中存在的一种内源性代谢物，可作为小鼠模型抑郁症的诊断生物标志物[1]。1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine可改变细胞膜的刚性，并能干扰肿瘤转移[2]。1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine被广泛用作内标，以开发电喷雾质谱法用于鉴定相关化合物[3]。
在体内，单次静脉注射5mg/kg剂量的1-heptadecanoyl-2-hydroxy-sn-glycero-3-phosphocholine，持续2小时，显著降低了小鼠冠状动脉内皮细胞(CAECs)中TRPV4与KCa3.1通道之间的相互作用，并减少了动脉段的血管舒张[4]。