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Home >> Signaling Pathways >> Neuroscience >> Alzheimer

Alzheimer(阿尔茨海默病)

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

Products for  Alzheimer

  1. Cat.No. 产品名称 Information
  2. GC43708 Fulvic Acid

    富里酸

     A fungal metabolite
  3. GC52047 Fustin

    黄颜木素,(±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone

     A flavanone with diverse biological activities
  4. GC52078 Galantamine (hydrobromide)

    氢溴酸加兰他敏

    An alkaloid with AChE inhibitory and nAChR potentiating activities
  5. GC47389 Galantamine-d3 (hydrobromide) An internal standard for the quantification of galantamine
  6. GC20007 Ginsenoside CK

    20(S)-人参皂苷 C-K; Compound K

     Ginsenoside CK，一种由主要人参皂苷化合物转化而来的次级人参皂苷，比其母体人参皂苷具有更高的生物利用度和溶解性，具有极其重要的意义。
  7. GC49273 Glycerophosphorylethanolamine (sodium salt)

    Glycerol 3-phosphorylethanolamine, Glycerylphosphorylethanolamine

     An active metabolite of phosphatidylethanolamine
  8. GC40114 Histone H3K4Me3 (1-10) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) Histone H3K4Me3 (1-10) is an N-terminal peptide fragment of histone H3 that corresponds to amino acid residues 2-11 of the human histone H3 sequence.
  9. GC43858 Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ART-K(Me3)-QTARKSTGGKAPRKQLA, H3K4(Me3), Histone H3 (1-21) (Lys4me3), Lys(Me3)4-Histone H3 (1-21)

    A peptide fragment of histone H3
  10. GC45480 Histone H3K4Me3 (1-25) amide (human mouse, rat, porcine, bovine) (trifluoroacetate salt)

    ART-K(Me3)-QTARKSTGGKAPRKQLATKAA-NH2, Histone H3 (1-25) (Lys4me3), H3K4me3, Lys(Me3)4-Histone H3 (1-25) amide

    A peptide fragment of histone H3
  11. GC47437 Humanin (human) (trifluoroacetate salt)

    HN

     A neuropeptide with diverse biological activities
  12. GC49493 IRL 1620 (trifluoroacetate salt)

    PMZ-1620, SPI 1620, Suc-Glu9, Ala11,15-ET-1(8-21)

     A peptide ETB receptor agonist
  13. GC52027 Isolariciresinol

    异落叶松脂素,(+)-Cyclolariciresinol

     A lignan with diverse biological activities
  14. GC49306 Isopimaric Acid

    异海松酸

     A diterpenoid resin acid
  15. GC18568 JNJ-40418677 A modulator of γ-secretase
  16. GC49436 L-3-n-Butylphthalide

    (-)-3-Butylphthalide, levo-3-n-Butylphthalide, (S)-(-)-3-Butylphthalide, L-NBP

     A phthalide with antiplatelet and neuroprotective activities
  17. GC47563 L-Glutamic Acid (ammonium salt)

    谷氨酸一铵

     An excitatory neurotransmitter
  18. GC49417 L-Serine-13C3

    L-丝氨酸-13C3,(-)-Serine-13C3; (S)-Serine-13C3

     An internal standard for the quantification of L-serine
  19. GC49461 L-Serine-d7

    L-丝氨酸-D7,(-)-Serine-d7; (S)-Serine-d7

     An internal standard for the quantification of L-serine
  20. GC45917 Leucettine L41 An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3
  21. GC19221 Leucomethylene blue Mesylate

    TRx0237 mesylate; Methylene blue leuco base mesylate

     An inhibitor of tau aggregation
  22. GC44130 Mca-EVKMDAEF-K(Dnp)-NH2 (ammonium salt)

    β-Secretase Fluorogenic Substrate

     A fluorogenic substrate for β-secretase
  23. GC44131 Mca-HQKLVFFA-K(Dnp)-NH2 (trifluoroacetate salt)

    α-Secretase Fluorogenic Substrate

     A fluorogenic substrate for α-secretase
  24. GC40078 Memantine-d6 (hydrochloride)

    盐酸美金刚 d6 (盐酸盐)

     An internal standard for the quantification of memantine
  25. GC44225 ML-345 An inhibitor of the insulin-degrading enzyme
  26. GP10006 Myelin Basic Protein (68-82), guinea pig

    豚鼠髓磷脂碱性蛋白片段68-82,H2N-Tyr-Gly-Ser-Leu-Pro-Gln-Lys-Ser-Gln-Arg-Ser-Gln-Asp-Glu-Asn-OH

    髓鞘碱性蛋白 (68-82)，豚鼠是髓鞘碱性蛋白 (MBP) 的片段。
  27. GP10130 Myelin Basic Protein (87-99)

    Val-His-Phe-Phe-Lys-Asn-Ile-Val-Thr-Pro-Arg-Thr-Pro

    An encephalitogenic peptide
  28. GC44416 N-methyl Mesoporphyrin IX

    N-甲基中卟啉IX

     N-methyl Mesoporphyrin IX（NMM）是卟啉的过渡态类似物，是亚铁螯合酶的有效抑制剂，Kd值为7 nM。N-methyl Mesoporphyrin IX是G-四链体的特异性染色剂，激发/发射最大值分别为399/610 nm。
  29. GC47746 NAP 226-90

    3-(1-(S)-(N,N-二甲基氨基)乙基)苯酚

     A metabolite of rivastigmine
  30. GC44399 NIAD-4 A fluorescent probe for Aβ
  31. GC52214 Nicotinamide riboside-d4 (triflate) An internal standard for the quantification of nicotinamide riboside
  32. GC49090 Nilvadipine-d4

    (±)-Nilvadipine-d4

     An internal standard for the quantification of nilvadipine
  33. GC72054 Obovatol Obovatol是一种从厚朴叶中分离出来的联苯醚木脂素。
  34. GC49815 Oleuropein aglycone

    3,4-DHPEA-EA

     A polyphenol with diverse biological activities
  35. GC91070 p-methyl-N-salicyloyl Tryptamine

    LZWL02003, para-methyl-N-salicyloyl Tryptamine

    一种神经保护剂
  36. GC49024 Palmitic Acid MaxSpec® Standard

    棕榈酸

     A long-chain saturated fatty acid
  37. GC49023 Palmitic Acid-d9 MaxSpec® Standard

    棕榈酸-13,13,14,14,15,15,16,16,16-D9

     A quantitative analytical standard guaranteed to meet MaxSpec identity, purity, stability, and concentration specifications
  38. GC39419 PBD-150 A glutaminyl cyclase inhibitor
  39. GC47955 Phloroglucinol

    间苯三酚

     A phenol with diverse biological activities
  40. GC49192 Piracetam-d6

    UCB-6215-d6

     An internal standard for the quantification of piracetam
  41. GC48362 PMX-205 (trifluoroacetate salt) A potent antagonist of C5aR
  42. GC44674 Pramlintide (acetate hydrate)

    醋酸普兰林肽

     An amylin analog
  43. GC46208 Propentofylline

    普罗潘非林,HWA 285

     A xanthine derivative and neuroprotective agent
  44. GC49108 Racecadotril-d5

    消旋卡多曲杂质,Acetorphan-d5

     An internal standard for the quantification of racecadotril
  45. GC48028 Rasagiline-13C3 (mesylate)

    甲磺酸雷沙吉兰-13C3

     An internal standard for the quantification of rasagiline
  46. GC18483 RU-505 An inhibitor of the Aβ and fibrinogen interaction
  47. GC19799 Selegiline hydrochloride

    盐酸司来吉兰; Deprenyl hydrochloride; (-)-Selegiline hydrochloride; (-)-Deprenyl hydrochloride

     A selective inhibitor of MAO-B
  48. GC12096 Semagacestat (LY450139)

    司马西特,LY-450139, LY 450139,Semagacestat

    A pan γ-secretase inhibitor
  49. GC40068 Setosusin

    (+)-Setosusin

     A fungal metabolite
  50. GC48083 sn-Glycerol-3-phosphate (cyclohexyl ammonium salt hydrate)

    G3P

     A neuropeptide with diverse biological activities
  51. GC45831 SRI-011381 SRI-011381是一种具口服活性的转化生长因子β（TGF-β）信号通路的激活剂，具有神经保护作用。

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