Alzheimer
Alzheimer(阿尔茨海默病)
Alzheimer
Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more
Alzheimer 相关产品(103)
- GC42802Amyloid-β (1-8, A2V) Peptide纯度: >98.00%
A truncated form of Aβ containing the A2V mutation
- GC42803Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt)纯度: >95.00%
An 11-residue amyloid-β protein fragment
- GC42937Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt)纯度: >95.00%
An affinity probe for Aβ42 binding partners
- GC43494DL-threo-PDMP (hydrochloride)CAS: 80938-69-8纯度: >98.00%
An inhibitor of sphingolipid biosynthesis
- GC43858Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC44131Mca-HQKLVFFA-K(Dnp)-NH2 (trifluoroacetate salt)纯度: >95.00%
A fluorogenic substrate for α-secretase
- GC44416N-methyl Mesoporphyrin IXCAS: 142234-85-3纯度: >95.00% / >97.50%
N-methyl Mesoporphyrin IX（NMM）是卟啉的过渡态类似物，是亚铁螯合酶的有效抑制剂，K d 值为7 nM。N-methyl Mesoporphyrin IX是G-四链体的特异性染色剂，激发/发射最大值分别为399/610 nm。
- GC44987TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)纯度: >95.00%
A fluorescently labeled amyloid-β peptide
- GC45480Histone H3K4Me3 (1-25) amide (human mouse, rat, porcine, bovine) (trifluoroacetate salt)纯度: >95.00%
A peptide fragment of histone H3
- GC45765Deferiprone-d3CAS: 1346601-82-8纯度: >99.00%
An internal standard for the quantification of deferiprone
- GC46134Dityrosine (hydrochloride)CAS: 2716849-01-1纯度: >95.00%
A neuropeptide with diverse biological activities
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC42802 | Amyloid-β (1-8, A2V) Peptide | - | >98.00% | |
A truncated form of Aβ containing the A2V mutation | ||||
| GC42803 | Amyloid-β (25-35) Peptide (human) (trifluoroacetate salt) | - | >95.00% | |
An 11-residue amyloid-β protein fragment | ||||
| GC42937 | Biotin-Amyloid-β (1-42) Peptide (trifluoroacetate salt) | - | >95.00% | |
An affinity probe for Aβ42 binding partners | ||||
| GC43274 | Citromycetin | 478-60-4 | >95.00% | |
A fungal metabolite | ||||
| GC43322 | CRANAD 28 | 1623747-97-6 | >98.00% | |
A fluorescent affinity probe for amyloid-β | ||||
| GC43494 | DL-threo-PDMP (hydrochloride) | 80938-69-8 | >98.00% | |
An inhibitor of sphingolipid biosynthesis | ||||
| GC43700 | FSB | 760988-03-2 | >95.00% | |
A fluorescent probe | ||||
| GC43708 | Fulvic Acid | 479-66-3 | >98.00% | |
A fungal metabolite | ||||
| GC43858 | Histone H3K4Me3 (1-21) (human, mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC44130 | Mca-EVKMDAEF-K(Dnp)-NH2 (ammonium salt) | - | >95.00% | |
A fluorogenic substrate for β-secretase | ||||
| GC44131 | Mca-HQKLVFFA-K(Dnp)-NH2 (trifluoroacetate salt) | - | >95.00% | |
A fluorogenic substrate for α-secretase | ||||
| GC44399 | NIAD-4 | 868592-56-7 | >98.00% | |
A fluorescent probe for Aβ | ||||
| GC44416 | N-methyl Mesoporphyrin IX | 142234-85-3 | >95.00% / >97.50% | |
N-methyl Mesoporphyrin IX（NMM）是卟啉的过渡态类似物，是亚铁螯合酶的有效抑制剂，K d 值为7 nM。N-methyl Mesoporphyrin IX是G-四链体的特异性染色剂，激发/发射最大值分别为399/610 nm。 | ||||
| GC44674 | Pramlintide (acetate hydrate) | 196078-30-5 | >95.00% | |
An amylin analog | ||||
| GC44987 | TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt) | - | >95.00% | |
A fluorescently labeled amyloid-β peptide | ||||
| GC45137 | Valproic Acid Acyl-D-Glucuronide | - | >95.00% | |
A metabolite of valproic acid | ||||
| GC45378 | Alaproclate (hydrochloride) | 60719-83-7 | >95.00% | |
An SSRI | ||||
| GC45480 | Histone H3K4Me3 (1-25) amide (human mouse, rat, porcine, bovine) (trifluoroacetate salt) | - | >95.00% | |
A peptide fragment of histone H3 | ||||
| GC45765 | Deferiprone-d3 | 1346601-82-8 | >99.00% | |
An internal standard for the quantification of deferiprone | ||||
| GC45831 | SRI-011381 | 1629138-41-5 | >99.50% | |
SRI-011381是一种具口服活性的转化生长因子β（TGF-β）信号通路的激活剂，具有神经保护作用。 | ||||
| GC45917 | Leucettine L41 | 1112978-84-3 | >98.00% | |
An inhibitor of DYRK1A, DYRK2, CLK1, and CLK3 | ||||
| GC46134 | Dityrosine (hydrochloride) | 2716849-01-1 | >95.00% | |
A neuropeptide with diverse biological activities | ||||
| GC46208 | Propentofylline | 55242-55-2 | >98.00% | |
A xanthine derivative and neuroprotective agent | ||||
| GC46451 | 16F16 | 922507-80-0 | >98.00% | |
A PDI inhibitor | ||||