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Alzheimer(阿尔茨海默病)

Alzheimer

Alzheimer’s disease (AD), a neurodegenerative disorder, is the most common cause of progressive dementia. Two microscopic characteristics of AD are extracellular amyloid plaques and intracellular neurofibrillary tangles. Amyloid β peptide (Aβ), derived from amyloid precursor protein (APP) by sequential protein cleavage, and other metabolites deposit around neurons and form amyloid plaques, which contribute to the disease’s pathogenesis. The neurofibrillary tangles are formed by the aggregation of phosphorylated tau proteins. Under pathogenic conditions, tau accumulates in dendritic spines and interferes with neurotransmission. The Aβoligomer promotes tau enrichment and facilitates disease progress. read more

Products for  Alzheimer

  1. Cat.No. 产品名称 Information
  2. GC52496 Sulfatide (bovine) (sodium salt)

    Galactosylceramide I3-sulfate, Ganglioside SM4, I3SO3-GalCer, SM4, Sulfated Galactocerebroside, 3-O-Sulfogalactosylceramide

    A mixture of isolated bovine sulfatides
  3. GC44968 Sulfatides (bovine) (sodium salt) Sulfatides are endogenous sulfoglycolipids with various biological activities in the central and peripheral nervous systems, pancreas, and immune system.
  4. GC44987 TAMRA-Amyloid-β (1-42) Peptide (trifluoroacetate salt)

    TAMRA-Aβ42, TAMRA-Aβ (1-42)

    A fluorescently labeled amyloid-β peptide
  5. GC91977 TrkB Agonist Prodrug R13

    TrkB-IN-1; Tropomyosin-related Kinase B Agonist Prodrug R13; Tropomyosin-related Kinase B Inhibitor 1

    TrkB Agonist Prodrug R13(R13)是原肌球蛋白相关激酶B(TrkB)激活剂7,8-二羟基黄酮的前药形式。
  6. GC45137 Valproic Acid Acyl-D-Glucuronide

    Valproic Acid Gluclonide

    A metabolite of valproic acid
  7. GC48969 Withanone

    NSC 179884

    A phytochemical with diverse biological activities
  8. GC91621 WLB-89462 WLB-89462 is a ligand of sigma intracellular receptor 2 (σ2 receptor).

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