C22 Galactosylceramide-d4 is intended for use as an internal standard for the quantification of C22 galactosylceramide by GC- or LC-MS. C22 Galactosylceramide is a sphingolipid that has been found in the central nervous system.1,2 C22 Galactosylceramide levels are increased in the spinal cord, but not the brain or liver, of mice fed a methionine-restricted diet.1 C22 Galactosylceramide has been found in postmortem hippocampus from patients with Alzheimer's disease.2 [Matreya, LLC.]
1.JovÉ, M., Ayala, V., RamÍrez-NÚÑez, O., et al.Specific lipidome signatures in central nervous system from methionine-restricted miceJ. Proteome Res.12(6)2679-2689(2013) 2.Hejazi, L., Wong, J.W.H., Cheng, D., et al.Mass and relative elution time profiling: Two-dimensional analysis of sphingolipids in Alzheimer's disease brainsBiochem. J.438(1)165-175(2011)