Donepezil-d4 (hydrochloride) is intended for use as an internal standard for the quantification of donepezil by GC- or LC-MS. Donepezil is a reversible acetylcholinesterase inhibitor (IC50 = 23 nM) that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine.1 As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil has been used to study cognition, memory, and behavior in animal models.2,3
1.MuÑoz-Torrero, D.Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's diseaseCurr. Med. Chem.152433-2455(2008) 2.Ramalingayya, G.V., Nampoothiri, M., Nayak, P.G., et al.Naringin and rutin alleviates episodic memory deficits in two differentially challenged object recognition tasksPharmacogn. Mag.12(Suppl 1)S63-S70(2016) 3.Shumizu, S., Mizuguchi, Y., Sobue, A., et al.Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in miceJ. Pharmacol. Sci.127(4)439-445(2015)