SYP-5

目录号: GC32876纯度: >99.50%

A HIF-1 inhibitor

Cas No.: 1384268-04-5

规格	价格	库存	数量
5mg	¥637.00	现货	1
10mg	¥980.00	现货	1
50mg	¥2,800.00	现货	1
100mg	¥4,200.00	现货	1
10mM (in 1mL DMSO)	¥701.00	现货	1

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文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例

Nature
641, 529–536 (2025)
Nature
628, 630–638 (2024)
Nature
632, 686–694 (2024)
Nature
618, 1017–1023 (2023)
Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
Science
387(6739) (2025)
Science
387(6734) (2025)
Cell Research
35, 97–116 (2025)
Cell Research
34, 683–706 (2024)
Cell Research
33, 273–287 (2023)
Cell Research
33, 546–561 (2023)
Cell Research
33, 904–922 (2023)
Cell Research
31, 1291–1307 (2021)

产品描述 Description

SYP-5 is an inhibitor of hypoxia-inducible factor-1 (HIF-1).¹ It inhibits HIF-1 activity in a reporter assay when used at concentrations ranging from 0.1 to 100 ?M. SYP-5 (2, 10, and 50 ?M) reduces hypoxia- or VEGF-induced capillary tube formation in human umbilical vein endothelial cells (HUVECs). It inhibits the migration and invasion of Hep3B hepatocellular carcinoma and BCaP-37 breast cancer cells in a concentration-dependent manner.

1.Wang, L.-H., Jiang, X.-R., Yang, J.-Y., et al.SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesisEur. J. Pharmacol.791560-568(2016)

实验参考方法 Experimental Reference Method

Cell experiment:

The cells (1×105 cells/mL) are seeded into 96-well culture plates. After overnight ncubation, the cells are treated with various concentrations of SYP-5 (2, 10, 50 μM) for 24 h. Then 10μLMTT) solution (2.5 mg/mL in PBS) is added to each well, and the plates are incubated for additional 4 h at 37°C. After centrifugation (2500 rpm, 10 min), the medium containing MTT is aspirated, and 100 μL DMSO is added. The optical density of each well is measured at 570 nm with a SpectraMax Paradigm Reader[1].

References:

[1]. Wang LH, et al. SYP-5, a novel HIF-1 inhibitor, suppresses tumor cells invasion and angiogenesis. Eur J Pharmacol. 2016 Nov 15;791:560-568.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号

1384268-04-5

SMILES

O=C(C1=C(O)C(C=CC(C)(C)O2)=C2C=C1)/C=C/C3=CC=CS3

分子式

C₁₈H₁₆O₃S

分子量

312.38 g/mol

溶解性

DMSO : 33.33 mg/mL (106.70 mM)

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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分子量 (MW)

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