GlpBio

Humanin (human) (trifluoroacetate salt)

目录号: GC47437纯度: >95.00%同义词: HN
A neuropeptide with diverse biological activities
Humanin (human) (trifluoroacetate salt)
Cas No.: N/A
规格价格库存数量操作
1mg¥5,051.00现货
1
5mg¥1,760.00现货
1
10mg¥2,970.00现货
1
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文献被引

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

Humanin is a neuroprotective peptide.1 It completely blocks amyloid-β (1-42) (Aβ42) and Aβ43-induced cell death of primary cortical neurons when used at a concentration of 10 μM. Humanin also prevents amyloid precursor protein (APP) antibody-induced cell death and reduces neurotoxicity in FH11 cells induced by the APP mutants A617G-APP, L648P-APP, V642I-APP, and NL-APP, which are associated with familial Alzheimer's disease (IC50s = 0.1-1 μM). In vivo, humanin (0.375 mg/kg per hour) increases systemic insulin sensitivity and enhances glucose uptake in skeletal muscle of rats.2

1.Hashimoto, Y., Niikura, T., Ito, Y., et al.Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer's disease-relevant insultsJ. Neurosci.21(23)9235-9245(2001) 2.Muzumdar, R.H., Huffman, D.M., Atzmon, G., et al.Humanin: A novel central regulator of peripheral insulin actionPLoS One4(7)e6334(2009)

产品文档 Product Documents

Purity:>95.00%Appearance:A solid

化学性质Chemical Properties

CAS 号
N/A
同义词
HN
SMILES
[H]N[C@H](C(N[C@H](C(N1CCC[C@H]1C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H](C(N[C@@H](CO)C(N[C@H](C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@]([C@@H](C)O)([H])C(N[C@@H](CO)C(N[C@@H](CCC(O)=O)C(N[C@]([C@H](CC)C)([H])C(N[C@H](C(N[C@@H](CC(C)C)C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)C)=O)=O)=O)=O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)CS)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)C)=O)CCSC.OC(C(F)(F)F)=O
分子式
C119H204N34O32S2.XCF3COOH
分子量
2687.2 g/mol
溶解性
Formic Acid: 1 mg/ml
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol