GlpBio

MCHR1 (GPR24)

MCHR1 (GPR24)(黑色素浓缩激素受体1)

MCHR1 (GPR24), also known as Melanin concentrating hormone receptor 1, belongs to a member of the G protein-coupled receptor family 1, is an integral plasma membrane protein which binds melanin-concentrating hormone, and is one of the melanin-concentrating hormone receptors found in all mammals. MCHR1 can inhibit cAMP accumulation and stimulate intracellular calcium flux, and is probably involved in the neuronal regulation of food consumption. Although structurally similar to somatostatin receptors, this protein does not seem to bind somatostatin. MCHR1 is thought to regulate appetite, and also functions in stress, anxiety and depression.

MCHR1 (GPR24) 相关产品(16)

  • GC10175 structure
    GC10175GW 803430
    CAS: 515141-51-2
    纯度: >98.00%

    An antagonist of MCH 1

  • GC10865 structure
    GC10865TC-MCH 7c
    CAS: 864756-35-4
    纯度: >99.00%

    TC-MCH 7c 是一种苯基吡啶酮衍生物，是一种口服的、选择性的、可穿透脑的 MCH1R 拮抗剂，对 hMCH1R 的 IC50 为 5.6 nM。

  • GC17846 structure
    GC17846SNAP 94847 hydrochloride
    CAS: 487051-12-7
    纯度: >99.50%

    An antagonist of MCH 1

  • GC31149 structure
    GC31149Melanin Concentrating Hormone, salmon (MCH (salmon))
    CAS: 87218-84-6

    黑色素浓缩激素鲑鱼 (MCH (salmon)) 是一种 19 个氨基酸的神经肽，最初在硬骨鱼的脑垂体中发现，可调节食物摄入、能量平衡、睡眠状态和心血管系统。

  • GC31388 structure
    GC31388ALB-127158(a)
    CAS: 1173154-32-9
    纯度: >99.50%

    ALB-127158(a)是一种有效的选择性黑色素浓缩激素1(MCH1)受体拮抗剂。

  • GC31422 structure
    GC31422MCH-1 antagonist 1
    CAS: 1039825-68-7

    MCH-1antagonist1是一种有效的黑色素浓缩激素1(MCH-1)拮抗剂，Ki值为2.6nM。MCH-1antagonist1还抑制CYP3A4，IC50为10μM。

  • GC31479 structure
    GC31479BMS-819881
    CAS: 1197420-05-5

    BMS-819881是一种黑色素浓缩激素受体1(MCHR1)拮抗剂，结合大鼠MCHR1，Ki值为7nM。BMS-819881还有效且选择性地作用于CYP3A4，EC50为13μM.

  • GC31504 structure
    GC31504NGD-4715
    CAS: 476322-70-0

    NGD-4715是选择性，有口服活性的黑色素浓缩激素受体1(melanin-concentratinghormonereceptor1(MCHR1))的拮抗剂。

  • GC31505 structure
    GC31505MCHr1 antagonist 2
    CAS: 863115-70-2
    纯度: >98.00%

    MCHr1antagonist2是一种黑色素聚集激素受体1(melaninconcentratinghormonereceptor1)拮抗剂，IC50值为65nM；MCHr1antagonist2同时抑制hERG，在IMR-32细胞中，IC50值为4.0nM。

  • GC31506 structure
    GC31506SB-568849
    CAS: 395679-53-5

    SB-568849是一种黑色素浓缩激素受体1(MCHR1)拮抗剂，pKi值为7.7。

  • GC31628 structure
    GC31628MCHr1 antagonist 1
    CAS: 391610-37-0

    MCHr1antagonist1是一种选择性的黑色素浓集激素1型受体(melaninconcentratinghormone-1receptor)拮抗剂，对人MCH1受体的Kb和Ki值分别为1nM和4nM，在降低体重方面可能起作用。

  • GC31643 structure
    GC31643AZD1979
    CAS: 1254035-84-1

    AZD1979是一个Melanin-concentratinghormonereceptor1(MCHr1)拮抗剂,其IC50值约为12nM。

  • GC36580 structure
    GC36580Melanin Concentrating Hormone, salmon (TFA)

    Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是最初在硬骨鱼的垂体中发现的 19 个氨基酸组成的神经肽，它调节食物摄入，能量平衡，睡眠状态和心血管系统。Melanin Concentrating Hormone, salmon TFA (MCH (salmon) TFA) 是 SLC-1/GPR24 和 MCHR2 的配体。

  • GC36727 structure
    GC36727Neuropeptide EI, rat
    CAS: 125934-45-4

    Neuropeptide EI, rat 是一种黑色素聚集激素 (MCH) 拮抗剂，同时是一种黑素细胞刺激素 (MSH) 激动剂。

  • GC40787 structure
    GC40787γ-Linolenic Acid ethyl ester
    CAS: 31450-14-3
    纯度: >98.00%

    Esterified form of γ-linolenic acid

  • GC63822 structure
    GC63822Ethyl linolenate
    CAS: 1191-41-9
    纯度: >98.00%

    An esterified form of α-linolenic acid