α-Linolenic acid ethyl ester is an esterified form of α-linolenic acid . It increases cyclin E levels and the activity of Cdk2/cyclin E, ERK, and JNK in hepatic stellate cells when used at a concentration of 50 μM.1 α-Linolenic acid ethyl ester (25 μg/ml) inhibits the growth of S. mutans, C. albicans, and P. gingivalis by 98, 72, and 92%, respectively, in vitro.2 It has been found in biodiesel produced from castor oil using ethanol.3 α-Linolenic acid ethyl ester has been used as a substrate in lipid peroxidation assays for antioxidant activity.4
1.Li, J., Hu, W., Baldassare, J.J., et al.The ethanol metabolite, linolenic acid ethyl ester, stimulates mitogen-activated protein kinase and cyclin signaling in hepatic stellate cellsLife Sci.73(9)1083-1096(2003) 2.Huang, C.B., and Ebersole, J.L.A novel bioactivity of omega-3 polyunsaturated fatty acids and their ester derivativesMol. Oral Microbiol.25(1)75-80(2010) 3.Concei??o, M.M., Fernandes, V.J., Jr., Bezerra, A.F., et al.Dynamic kinetic calculation of castor oil biodieselJ. Therm. Anal. Calorim.87(3)865-869(2007) 4.Miyake, T., and Shibamoto, T.Antioxidative activities of natural compounds found in plantsJ. Agric. Food Chem.45(5)1819-1822(1997)