MCHr1 antagonist 1 is a selective antagonist of melanin concentrating hormone-1 (MCH1) receptor, with a Kb of 1 nM and a Ki of 4 nM at human MCH1, and may be used to reduce the body mass.
MCHr1 antagonist 1 shows potent activities against melanin concentrating hormone-1 receptor, but less potent against human MCH1, NPY1, NPY5, GALR1, GALR2, GALR3, and rat 5HT2C receptors, with Kis of >50000 nM[1].
[1]. Selective melanin concentrating hormone-1 (MCH1) receptor antagonists and uses thereof. US 20030069261 A1