Monoamine Oxidase
Monoamine Oxidase(单胺氧化酶)
Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.
Monoamine Oxidase 相关产品(91)
- GC11703Moclobemide (Ro 111163)CAS: 71320-77-9纯度: >99.50%
Moclobemide (Ro 111163)是一种可透过血脑屏障的可逆的单胺氧化酶A（MAO-A）抑制剂，对hMAO-A的IC 50 值为6.061μM。
- GC13016SafinamideCAS: 133865-89-1纯度: >99.50%
Safinamide 是一种强效、选择性和可逆的单胺氧化酶 B (MAO-B) 抑制剂 (IC50=0.098 μM)，优于 MAO-A (IC50=580 μM)。
- GC14122Clorgyline (hydrochloride)CAS: 17780-75-5纯度: >99.50%
Clorgyline (hydrochloride)是一种不可逆、强效和选择性单胺氧化酶（MAO）A 抑制剂，对MAO-A和MAO-B的K i 值分别为0.054和58μM，IC 50 值分别为 0.0012和1.9μM。
- GC19311Ro 41-1049 hydrochlorideCAS: 127917-66-2纯度: >99.50%
Ro 41-1049 hydrochloride 是单胺氧化酶-A (MAO-A) 的可逆选择性抑制剂。
- GC30051Methylene Blue (Basic Blue 9)CAS: 61-73-4纯度: >98.00% / >99.00%
Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase.
- GC30392Desmethoxyyangonin (Demethoxyyangonin)CAS: 15345-89-8纯度: >99.00%
An Analytical Reference Standard
- GC30544(2-Chloropyridin-4-yl)methanamine hydrochlorideCAS: 916210-98-5纯度: >98.50%
(2-Chloropyridin-4-yl)methanamine hydrochloride是一种高选择性的赖氨酰氧化酶样蛋白-2（LOXL2）抑制剂，其IC 50 为126nM。
- GC30766Tranylcypromine hemisulfate (dl-Tranylcypromine hemisulfate)CAS: 13492-01-8纯度: >99.00%
Tranylcypromine (Parnate) is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity.
- GC30949Minaprine dihydrochlorideCAS: 25953-17-7纯度: >99.50%
Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂，还对乙酰胆碱酯酶有微弱抑制，抗抑郁类化合物。
- GC30963Eprobemide (LIS 630)CAS: 87940-60-1纯度: >99.50%
Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia.
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC11703 | Moclobemide (Ro 111163) | 71320-77-9 | >99.50% | |
Moclobemide (Ro 111163)是一种可透过血脑屏障的可逆的单胺氧化酶A（MAO-A）抑制剂，对hMAO-A的IC 50 值为6.061μM。 | ||||
| GC12801 | Rasagiline Mesylate | 161735-79-1 | >99.50% | |
An inhibitor of MAO-B | ||||
| GC12962 | Isatin | 91-56-5 | >98.00% | |
Isatin (Indoline-2,3-dione) 是一种有效的单胺氧化酶 (MAO) 抑制剂，IC50 为 3 μM。 | ||||
| GC13016 | Safinamide | 133865-89-1 | >99.50% | |
Safinamide 是一种强效、选择性和可逆的单胺氧化酶 B (MAO-B) 抑制剂 (IC50=0.098 μM)，优于 MAO-A (IC50=580 μM)。 | ||||
| GC14122 | Clorgyline (hydrochloride) | 17780-75-5 | >99.50% | |
Clorgyline (hydrochloride)是一种不可逆、强效和选择性单胺氧化酶（MAO）A 抑制剂，对MAO-A和MAO-B的K i 值分别为0.054和58μM，IC 50 值分别为 0.0012和1.9μM。 | ||||
| GC15384 | Harmane | 486-84-0 | >99.50% | |
A β-carboline with diverse biological activities | ||||
| GC16824 | Pargyline (hydrochloride) | 306-07-0 | >99.50% / >99.00% | |
An irreversible MAO inhibitor | ||||
| GC17314 | OG-L002 | 1357302-64-7 | >99.50% | |
An LSD1 inhibitor | ||||
| GC19311 | Ro 41-1049 hydrochloride | 127917-66-2 | >99.50% | |
Ro 41-1049 hydrochloride 是单胺氧化酶-A (MAO-A) 的可逆选择性抑制剂。 | ||||
| GC30051 | Methylene Blue (Basic Blue 9) | 61-73-4 | >98.00% / >99.00% | |
Methylene Blue (Basic Blue 9, Tetramethylthionine chloride, methylthioninium chloride, CI-52015) is used as a dye in chromoendoscopy. It Inhibits tau filament formation with IC50 of 1.9μM. Also it inhibits soluble guanylyl cyclase. | ||||
| GC30112 | PAT-1251 | 2007885-39-2 | >99.50% | |
PAT-1251是一种赖氨酰氧化酶样蛋白2（LOXL2；IC 50 =0.71μM）抑制剂。 | ||||
| GC30218 | Minaprine | 25905-77-5 | - | |
Minaprine dihydrochloride is hydrochloride salt form of Minaprine, which acts as a reversible inhibitor of MAO-A in rats and weakly inhibit acetylcholinesterase in rat brain (striatum) homogenates. | ||||
| GC30362 | MAO-B-IN-1 | 1124198-17-9 | - | |
MAO-B-IN-1是一种monoamineoxidaseB抑制剂，可用于精神疾病的研究。 | ||||
| GC30392 | Desmethoxyyangonin (Demethoxyyangonin) | 15345-89-8 | >99.00% | |
An Analytical Reference Standard | ||||
| GC30544 | (2-Chloropyridin-4-yl)methanamine hydrochloride | 916210-98-5 | >98.50% | |
(2-Chloropyridin-4-yl)methanamine hydrochloride是一种高选择性的赖氨酰氧化酶样蛋白-2（LOXL2）抑制剂，其IC 50 为126nM。 | ||||
| GC30766 | Tranylcypromine hemisulfate (dl-Tranylcypromine hemisulfate) | 13492-01-8 | >99.00% | |
Tranylcypromine (Parnate) is an irreversible inhibitor of monoamine oxidase (MAO) with a rapid onset of activity. | ||||
| GC30773 | Phenelzine sulfate | 156-51-4 | >99.00% | |
Phenelzine sulfate是一种单胺氧化酶（MAO）抑制剂。 | ||||
| GC30870 | Nialamide | 51-12-7 | - | |
Nialamide是一种非选择性的,不可逆的单胺氧化酶抑制剂(MAOI),用作抗抑郁药。 | ||||
| GC30949 | Minaprine dihydrochloride | 25953-17-7 | >99.50% | |
Minaprine二盐酸盐是单胺氧化酶MAO-A可逆性抑制剂，还对乙酰胆碱酯酶有微弱抑制，抗抑郁类化合物。 | ||||
| GC30963 | Eprobemide (LIS 630) | 87940-60-1 | >99.50% | |
Eprobemide is a reversible monoamine oxidase A (MAO-A) inhibitor. Eprobemide acts as an antidepressant in Russia. | ||||
| GC30976 | Modaline sulfate | 2856-75-9 | >98.50% | |
Modaline硫酸盐是MAO抑制剂,用于治疗抑郁症。 | ||||
| GC30979 | Lazabemide (Ro 19-6327) | 103878-84-8 | >99.50% | |
An inhibitor of MAO-B | ||||
| GC30988 | TB5 | 948841-07-4 | - | |
A potent and selective MAO-B inhibitor | ||||
| GC31021 | 2614W94 | 205187-35-5 | - | |
2614W94是具有选择性的，可逆的monoamineoxidase-A抑制剂，IC50值和Ki值分别为5nM和1.6nM。 | ||||