GlpBio

Monoamine Oxidase

Monoamine Oxidase(单胺氧化酶)

Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase 相关产品(91)

  • GC31024 structure
    GC31024RS 8359
    CAS: 105365-76-2

    RS8359是一种选择性的，可逆的MAO-A抑制剂，具有抗抑郁的功效。

  • GC31094 structure
    GC31094CR4056
    CAS: 1004997-71-0

    CR4056是一个选择性的人重组MAO-A抑制剂，其IC50值为202.7nM。CR4056也是咪唑啉-2受体(I2R)的配体，其IC50值为596nM。

  • GC31104 structure
    GC31104Isocarboxazid
    CAS: 59-63-2
    纯度: >98.50%

    An inhibitor of MAO

  • GC31155 structure
    GC31155CX-157
    CAS: 205187-53-7

    CX-157是一个可逆的单胺氧化酶-A(MAO-A)抑制剂，其EC50值为19.3ng/mL。

  • GC31252 structure
    GC31252MAO-IN-1
    CAS: 124991-40-8
    纯度: >99.00%

    MAO-IN-1是单胺氧化酶B(MAOB)的抑制剂，IC50值为20nM。

  • GC31890 structure
    GC31890PXS-5153A
    CAS: 2125956-82-1

    PXS-5153A是一种有效的、选择性的、具有口服活性和快速起效的赖氨酰氧化酶2/3(LOXL2/LOXL3)的双抑制剂，对几乎所有哺乳动物LOXL2的IC50均<40nM，对人类LOXL3的IC50为63nM。PXS-5153A可减少交联，改善纤维化。

  • GC31949 structure
    GC31949PAT-1251 Hydrochloride
    CAS: 2098884-53-6

    PAT-1251是一种赖氨酰氧化酶样蛋白2（LOXL2；IC 50 =0.71μM）抑制剂。

  • GC32764 structure
    GC32764GSK-LSD1 Dihydrochloride
    CAS: 2102933-95-7
    纯度: >98.00%

    An LSD1 inhibitor

  • GC33573 structure
    GC33573Rasagiline 13C3 mesylate racemic (AGN1135 13C3 racemic)
    CAS: 1216757-55-9

    Rasagiline 13C3 mesylate racemic (AGN1135 13C3 racemic) 是一种 13C 标记的 Rasagiline mesylate 外消旋体。

  • GC33677 structure
    GC33677Iproniazid phosphate
    CAS: 305-33-9
    纯度: >98.00%

    Iproniazid (Marsilid, Iprazid) phosphate is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent.

  • GC33686 structure
    GC33686(S)-Rasagiline (TVP1022)
    CAS: 185517-74-2
    纯度: >99.00%

    (S)-雷沙吉兰 (TVP1022) (TVP1022) 是雷沙吉兰相对无活性的 S-对映异构体形式。

  • GC33714 structure
    GC33714Rasagiline (AGN1135)
    CAS: 136236-51-6
    纯度: >98.50%

    An inhibitor of MAO-B

  • GC33718 structure
    GC33718Brofaromine (CGP 11305A)
    CAS: 63638-91-5
    纯度: >98.50%

    Brofaromine (CGP 11305A) (CGP 11305A) 是一种单胺氧化酶 (MAO) 抑制剂，IC50 为 0.2μ；MAO-A 为 M。

  • GC33749 structure
    GC33749Salsolidine
    CAS: 5784-74-7

    An alkaloid

  • GC33983 structure
    GC33983Amitraz (BTS-27419)
    CAS: 33089-61-1

    A formamidine acaricide

  • GC34842 structure
    GC34842Toloxatone
    CAS: 29218-27-7
    纯度: >99.00%

    An inhibitor of MAO-A

  • GC35006 structure
    GC35006(S)-Rasagiline mesylate
    CAS: 202464-88-8

    (S)-Rasagiline (TVP1022) 甲磺酸盐是S-构型Rasagiline，对MAO-B的活性弱。

  • GC35192 structure
    GC351927-Hydroxy-3,4-dihydro-2(1H)-quinolinone
    CAS: 22246-18-0
    纯度: >99.50%

    7-Hydroxy-3,4-dihydrocarbostyril is used as the materials for the organic synthesis intermediates.

  • GC36638 structure
    GC36638Mofegiline hydrochloride
    CAS: 120635-25-8

    An inhibitor of MAO-B

  • GC36853 structure
    GC36853Pargyline
    CAS: 555-57-7
    纯度: >98.00%

    An irreversible MAO inhibitor

  • GC37558 structure
    GC37558Rosmarinic acid racemate
    CAS: 537-15-5

    Rosmarinic acid racemate是Rosmarinic acid的外消旋体。Rosmarinic acid抑制MAO-A, MAO-B 和COMT酶，IC50分别为50.1, 184.6 和26.7 μM。

  • GC38583 structure
    GC38583PXS-5153A monohydrochloride
    纯度: >99.50%

    PXS-5153A monohydrochloride 是一种有效的、选择性的、具有口服活性和快速起效的赖氨酰氧化酶 2/3 (LOXL2/LOXL3) 的双抑制剂，对几乎所有哺乳动物LOXL2的IC50 均< 40 nM，对人类LOXL3 的IC50 为63 nM。PXS-5153A monohydrochloride 可减少交联，改善纤维化。

  • GC39018 structure
    GC39018Obtusin
    CAS: 70588-05-5

    Obtusin 是来自决明子种子，是一种高度选择性和竞争性的人单胺氧化酶-A (hMAO-A) 抑制剂，IC50 为 11.12 μM，Ki 为 6.15。Obtusin 在神经退行性疾病，尤其是焦虑和抑郁中起预防作用。

  • GC39187 structure
    GC39187Azure B
    CAS: 531-55-5

    Azure B 是一种阳离子染料 (cationic dye)，是 Methylene blue 的主要代谢物，用于 Azure 曙红染色剂以进行血液涂片染色。Azure B 是一种高效、选择性和可逆的抑制单胺氧化酶 (MAO)-A 的抑制剂，对重组人的 MAO-A 和 MAO-B 的IC50 分别为 11 和 968 nM。Azure B 具有显著的抗抑郁作用。