TB5

目录号: GC30988纯度: >98%

A potent and selective MAO-B inhibitor

Cas No.: 948841-07-4

规格	价格	库存	数量	操作
50 mg	¥2,340.00	现货	1
100 mg	¥3,420.00	现货	1

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Nature
641, 529–536 (2025)
Nature
628, 630–638 (2024)
Nature
632, 686–694 (2024)
Nature
618, 1017–1023 (2023)
Nature
610, 366–372 (2022)
Cell
187(9):2288-2304 (2024)
Cell
183(7):1867-1883 (2020)
Science
388(6745) (2025)
Science
387(6739) (2025)
Science
387(6734) (2025)
Cell Research
35, 97–116 (2025)
Cell Research
34, 683–706 (2024)
Cell Research
33, 273–287 (2023)
Cell Research
33, 546–561 (2023)
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33, 904–922 (2023)
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31, 1291–1307 (2021)

产品描述 Description

TB5 is a potent and selective monoamine oxidase B (MAO-B) inhibitor with K_i values of 110 and 1,450 nM for MAO-B and MAO-A, respectively.¹ It interacts with the catalytic site of human MAO-B in a competitive manner. In an enzyme assay, MAO-B activity increases?from 37% to 97% following inhibitor washout, indicating TB5 binding is reversible.?TB5 also demonstrates permeability in a parallel artificial membrane permeation assay (PAMPA), a model for the blood-brain barrier, and has minimal cytotoxicity (>84% cell viability) in HepG2 cells at a concentrations up to 25 μM.

1.Mathew, B., Haridas, A., U?ar, G., et al.Synthesis, biochemistry, and computational studies of brominated thienyl chalcones: A new class of reversible MAO-B inhibitorsChemMedChem11(11)1161-1171(2016)

实验参考方法 Experimental Reference Method

Kinase experiment:

Compounds are dissolved in DMSO (5 mg/mL) and diluted with PBS/EtOH (70:30).Kinetic analyses are carried out for TB5 and TB8. A set of Lineweaver–Burk plots are constructed in the absence and presence of various concentrations of compounds TB5 and TC8. The set consists of five graphs, each constructed by measuring MAO-B and MAO-A catalytic rates at different substrate concentrations (0.1-1 μM). The first Lineweaver–Burk plot is constructed in the absence of inhibitor, while the remaining four graphs are constructed in the presence of different concentrations of TB5 and TB8[1].

Cell experiment:

In vitro cytotoxicity of brominated thiophene chalcones and standard MAO inhibitors are tested in human HepG2 hepatic cancer cells at three different concentrations (1, 5 and 25 μM)[1].

References:

[1]. Mathew B, et al. Synthesis, Biochemistry, and Computational Studies of Brominated Thienyl Chalcones: A New Class of Reversible MAO-B Inhibitors. ChemMedChem. 2016 Jun 6;11(11):1161-71.

产品文档 Product Documents

Purity:>98%

COA SDS Data Sheet

化学性质Chemical Properties

CAS 号

948841-07-4

SMILES

O=C(C1=CC=C(Br)S1)/C=C/C2=CC=C(N(C)C)C=C2

分子式

C₁₅H₁₄BrNOS

分子量

336.25 g/mol

溶解性

DMF: 33 mg/ml,DMSO: 33 mg/ml,Ethanol: 1 mg/ml

保存条件

Store at -20°C

General tips

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。

Shipping Condition

评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

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