C19 Ceramide is a naturally occurring ceramide that has been found in J. juncea extracts as well as rat brain and mouse heart.[1],[2],[3] It is elevated in adult and decreased in juvenile whole rat brain extracts by 114 and 37%, respectively, following chronic ethanol exposure.[2] C19 Ceramide is also increased in mouse hearts following administration of angiotensin II.[3]
Reference:
[1]. Krishna, N., Muralidhar, P., Kumar, M.M., et al. A new sphingolipid from the gorgonian Junceella juncea of the Indian ocean. Nat. Prod. Res. 18(6), 551-555 (2004).
[2]. Roux, A., Muller, L., Jackson, S.N., et al. Chronic ethanol consumption profoundly alters regional brain ceramide and sphingomyelin content in rodents. ACS Chem Neurosci. 6(2), 247-259 (2015).
[3]. Glenn, D.J., Cardema, M.C., Ni, W., et al. Cardiac steatosis potentiates angiotensin II effects in the heart. Am. J. Physiol. Heart Circ. Physiol. 308(4), H339-350 (2015).