SP-8356, an anti-inflammatory synthetic verbenone derivative, is a CD147 inhibitor with respect to its regulation of breast cancer cell behavior and cancer progression.
SP-8356, a synthetic anti-inflammatory verbenone derivative, exerts remarkable anti-atherosclerotic effects through inhibiting CD147-CypA interactions and reducing CypA-induced MMP-9 activation and monocyte adhesion.[2]
SP-8356 suppresses collagenase activity, MMP-9, and CypA, preventing the formation of plaque and attenuates its vulnerability in mice models of atherosclerosis.[2]
[1] Pahk K, et al. J Transl Med. 2019 Aug 20;17(1):274. [2] Pahk K, et al. Int J Mol Sci. 2019 Dec 21;21(1):95.