C16 Sphingomyelin (d18:1/16:0) is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position [1]. C16 Sphingomyelin interacts favorably with sterols, jointly forming a domain rich in Sphingomyelin/sterols. [2]. The variation in the content of C16 Sphingomyelin can lead to various pathological changes in the placenta[3]. C16 Sphingomyelin (d18:1/16:0) can be used as an internal reference to develop a new type of electrospray ionization mass spectrometry method for identifying related compounds in fibroblast and neuron cells[4].
References:
[1] Chakraborty M, Jiang X C. Sphingomyelin and its role in cellular signaling[J]. Lipid-mediated Protein Signaling, 2013: 1-14.
[2] Slotte J P, Ramstedt B. The functional role of sphingomyelin in cell membranes[J]. European journal of lipid science and technology, 2007, 109(10): 977-981.
[3] Yamazaki K, Masaki N, Kohmura-Kobayashi Y, et al. Decrease in sphingomyelin (d18: 1/16: 0) in stem villi and phosphatidylcholine (16: 0/20: 4) in terminal villi of human term placentas with pathohistological maternal malperfusion[J]. PLoS One, 2015, 10(11): e0142609.
[4] Valsecchi M, Mauri L, Casellato R, et al. Ceramide and sphingomyelin species of fibroblasts and neurons in culture[J]. Journal of lipid research, 2007, 48(2): 417-424.
C16 Sphingomyelin (d18:1/16:0)是一种鞘磷脂形式，可变酰化位点包含palmitate (16:0) [1]。C16 Sphingomyelin与甾醇良好地相互作用，共同形成富含鞘磷脂/甾醇的结构域[2]。C16 Sphingomyelin含量的变化可导致胎盘发生多种病理改变[3]。C16 Sphingomyelin可作为内标物，用于开发新型电喷雾电离质谱法，以鉴定成纤维细胞和神经元细胞中的相关化合物[4]。