Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC10126 Desipramine hydrochloride

盐酸去甲咪嗪；盐酸地昔帕明
Desipramine hydrochloride 是去甲肾上腺素转运蛋白 (NET)、5-HT 转运蛋白 (SERT) 和多巴胺转运蛋白 (DAT) 的抑制剂，Kis 分别为 4、61 和 78,720 nM。
GC49858 Desipramine-d4 (hydrochloride)

盐酸去郁敏D4
An internal standard for the quantification of desipramine
GC16416 Desloratadine

地氯雷他定; Sch34117
A histamine H₁ receptor antagonist and an active metabolite of loratadine
GC47196 Desloratadine-d4

Sch34117-d4
An internal standard for the quantification of desloratadine
GC30392 Desmethoxyyangonin (Demethoxyyangonin)

去甲氧基醉椒素,Demethoxyyangonin; 5,6-Dehydrokavain
An Analytical Reference Standard
GC62926 Desmethyl cariprazine Desmethyl cariprazine 是 Cariprazine 的活性代谢产物。Cariprazine，是抗精神病药候选药物，结合 D3, D2 和 5-HT1A 的 Ki 为 0.085 nM，0.49 nM，2.6 nM。
GC49202 Desmethyl Mirtazapine (hydrochloride)

盐酸去甲基米氮平
A metabolite of mirtazapine
GC64136 Desmethyl Naproxen-d3 Desmethyl Naproxen-d3 是 Desmethyl Naproxen。Desmethyl Naproxen 是抗炎剂 Naproxen 的代谢物。
GC13120 Desmethyl-YM 298198 mGlu1-selective antagonist
GC43422 Desmethyldoxepin (hydrochloride)

N-去甲盐酸多塞平,Desmethyldoxepin hydrochloride
The primary metabolite of doxepin
GC43423 Desmethylene Paroxetine (hydrochloride)

帕罗西汀杂质5
A major metabolite of the SSRI paroxetine
GC11570 Desvenlafaxine

去甲文拉法辛; O-Desmethylvenlafaxine
An active metabolite of venlafaxine
GC14262 Desvenlafaxine Succinate

琥珀酸去甲文拉法辛; O-Desmethylvenlafaxine succinate hydrate
An active metabolite of venlafaxine
GC18139 Devazepide

地伐西匹; L-364,718; MK-329
Devazepide (L-364,718) 是一种有效、竞争性、选择性和口服活性的胆囊收缩素 (CCK) 受体非肽拮抗剂，对大鼠胰腺、牛胆囊和豚鼠脑 CCK 受体的 IC50 分别为 81 pM、45 pM 和 245 nM .
GC47202 Dexamethasone-d4

地塞米松,Hexadecadrol-d4; Prednisolone F-d4
An internal standard for the quantification of dexamethasone
GC43427 Dexchlorpheniramine (maleate)

马来酸右氯苯那敏; S-(+)-Chlorpheniramine maleate salt
A histamine H₁ receptor antagonist
GC35845 Dexetimide

右苄替米特,(+)-Benzetimide; (S)-(+)-Dexetimide; Dexbenzetimide
Dexetimide ((+)-Benzetimide) 是一种高亲和力的毒蕈碱受体拮抗剂，也是强效持久抗胆碱药，可用于治疗神经抑制性帕金森病。
GC35846 Dexloxiglumide

右氯谷胺
A CCK₁ receptor antagonist
GC35847 Dexpramipexole

右旋普拉克索; (R)-Pramipexole; R-(+)-Pramipexole; KNS-760704
Dexpramipexole(KNS-760704)也叫R-(+)-Pramipexole，是神经保护剂，是弱的非麦角类多巴胺受体激动剂。
GC35848 Dexpramipexole dihydrochloride

右旋普拉克索二盐酸盐; (R)-Pramipexole dihydrochloride; R-(+)-Pramipexole dihydrochloride; KNS-760704 dihydrochloride
An anti-apoptotic antioxidant
GC71511 Dexpramipexole-d3 dihydrochloride Dexpramipexole-d3 dihydrochloride是氘标记的右旋普拉克索。
GC11246 DFB

DFB
A positive allosteric modulator of mGluR5
GC43437 Diallyl Disulfide

二烯丙基二硫
A natural H₂S donor
GC35858 Dianicline Dianicline是一种α4β2烟碱型乙酰胆碱受体部分激动剂，一类包括伐尼克兰和金雀花碱的戒烟药物。
GC18517 Diapocynin An inhibitor of NADPH-oxidase
GC47210 Dichlorphenamide-13C6

Diclofenamide-13C6
An internal standard for the quantification of dichlorphenamide
GC11090 Diclofenac

双氯芬酸
双氯芬酸是一种有效的非选择性抗炎药，作为 COX 抑制剂，对人 COX-1 和 COX-2 在 CHO 细胞中的 IC50 分别为 4 和 1.3 nM ，对羊 COX-1 的 IC50 分别为 5.1 和 0.84 μM和 COX-2，分别。
GC47212 Diclofenac amide

1-(2,6-二氯苯基)-1,3-二氢-2H-吲哚-2-酮
A prodrug form of diclofenac
GC14587 Diclofenac Diethylamine

双氯芬酸二乙胺
An NSAID and a COX inhibitor
GC43446 Diclofenac ethyl ester An esterified form of diclofenac
GC43447 Diclofenac methyl ester

双氯酚甲酯
A prodrug form of diclofenac
GC14622 Diclofenac Potassium

双氯芬酸钾
双氯芬酸钾是一种有效的非选择性抗炎剂，作为 COX 抑制剂，对人 COX-1 和 COX-2 在 CHO 细胞中的 IC50 分别为 4 和 1.3 nM ，对羊 COX- 的 IC50 分别为 5.1 和 0.84 μM。 1 和 COX-2，分别。
GC14261 Diclofenac Sodium

双氯芬酸钠; GP 45840
An NSAID and a COX inhibitor
GC47213 Diclofenac-d4

双氯芬酸 D4
An internal standard for the quantification of diclofenac
GC18187 Diclofensine (hydrochloride)

4-(3,4-二氯苯)-7-甲氧基-2-甲基-1,2,3,4-四氢异喹啉盐酸盐,Ro 8-4650 hydrochloride
An Analytical Reference Standard
GC33711 Diclofensine (Ro 8-4650)

(+/-)-双氮奋兴,Ro 8-4650
Diclofensine (Ro 8-4650)(Ro-8-4650) 是一种有效的单胺再摄取抑制剂，阻断大鼠脑突触体对多巴胺、去甲肾上腺素和血清素的摄取，IC50 值分别为 0.74、2.3 和 3.7 nM。
GC70918 Dicloromezotiaz Dicloromezotiaz是一种作用于烟碱乙酰胆碱受体(nAChRs)的强效杀虫剂。
GC62932 Didesmethyl cariprazine Didesmethyl cariprazine 是 Cariprazine 的代谢物，作为主要的循环活性部分。Didesmethyl cariprazine 的半衰期较长，为 1-3 周。Cariprazine是一种新型抗精神病候选药物，能结合 D3, D2 和 5-HT1A 。
GC43450 Dieldrin

Aldrin epoxide, Dieldrex, exo-Dieldrin

Dieldrin is an organochlorine insecticide and an antagonist of GABAA receptors (IC50 = 3.27 μM in rat brain vesicles).
GC49304 Difelikefalin (trifluoroacetate salt)

CR845, FE 202845
A κ-opioid receptor agonist
GC12591 Diflunisal

二氟尼柳,MK-647
A non-selective COX inhibitor
GC35864 Dihydrexidine

DAR-0100
Dihydrexidine (DAR-100) 是一种高效、选择性和全效的 D1 多巴胺受体激动剂，IC50 值为 10 nM，对 D2 受体有一定的亲和力。Dihydrexidine (DAR-100) 具有高效的抗帕金森活性。
GC60774 Dihydro Donepezil

盐酸多奈哌齐二氢杂质,Dihydro E2020
DihydroDonepezil(DihydroE2020)是Donepezil的代谢产物。Donepezil是一种有效的特异性AChE抑制剂，对bAChE和hAChE的IC50分别为8.12nM和11.6nM。
GC13118 Dihydro-β-erythroidine hydrobromide

DHβE hydrobromide
Dihydro-β-erythroidine (DHβE) hydrobromide 是一种有效的、具有口服活性的竞争性神经元 nAChR 拮抗剂。
GC13256 Dihydroergocristine mesylate

甲磺酸双氢麦角汀,DHEC mesylate

An alkaloid with diverse biological activities
GC14558 Dihydroergotamine mesylate

甲磺酸二氢麦角胺
An agonist of 5-HT_1B and 5-HT_1D receptors
GC10530 Dihydroergotoxine mesylate

甲磺酸二氢麦角碱; Ergoloid mesylates
A mixture of alkaloids with diverse biological activities
GC40143 Dihydrotetrabenazine

反式(2,3)-二氢丁苯那嗪
An active metabolite of tetrabenazine
GC63620 Dihydrowithaferin A

二氢醉茄素A; 2,3-Dihydrowithaferin A
Dihydrowithaferin A (2, 3-dihydrowithaferin A) 是一种从 Withania somnifera 分离的睡茄内酯类化合物。Dihydrowithaferin A 对乙酰胆碱酯酶有抑制活性。
GC49325 Dihydroxyacetone Phosphate (magnesium salt hydrate)

DHAP, Glycerone Phosphate
甘油脂前体