Neuroscience(神经科学)

Neuroscience

Neurons communicate with each other, effector organs and sensory organs through the neurotransmitter – receptor pathway at synapses. Neurotransmitters can be divided into 4 major groups: 1. Amino acids (glumate, aspartate, serine, glycine and GABA); 2. Monoamines (norepinephrine, epinephrine, dopamine, histamine, and serotonin); 3. Peptides (opioid peptides, substance P, somatostatin); and 4. Others (acetylcholine, NO, nucleosides). read more

Products for Neuroscience

Cat.No. 产品名称 Information
GC39344 BAY-1797 A P2X₄ receptor antagonist
GC39342 AZD7325
BAER-101
A positive allosteric modulator of α₂- and α₃ subunit-containing GABA_A receptors
GC50644 SK 609 Dopamine D3 receptor biased agonist
GC50564 PRX 07034
5-氯-2,3-二甲氧基-Α-甲基-N-[2-(甲基磺酰基)-5-(1-哌嗪基)苯基]-苯甲胺盐酸盐
PRX 07034 是一种高度选择性和有效的 5-HT6 受体拮抗剂，Ki = 4-8 nM，IC50 为 19 nM。
GC50446 DREADD agonist 21 dihydrochloride A muscarinic hM3Dq DREADD agonist
GC50433 GNE 9278 Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
GC50405 JNJ 39758979 dihydrochloride 高亲和力和选择性组胺H4拮抗剂；口服生物利用度
GC50401 RAGE antagonist peptide
拮抗剂多肽RAGEANTAGONIST
RAGE 拮抗剂肽是一种晚期糖基化终产物 (RAGE) 拮抗剂。
GC50390 TAT-Gap19 TAT-Gap19 是一种 Cx 模拟肽，是一种特异性的连接蛋白 43 半通道 (Cx43 HC) 抑制剂。
GC50375 PZ-II-029 α6β3γ2-selective GABAA positive allosteric modulator
GC50355 NS 6740
High affinity α7 nAChR partial agonist; anti-inflammatory
GC50329 M 30 dihydrochloride M 30 dihydrochloride 是一种具有口服活性、脑渗透性和脑选择性的不可逆 MAO-A (IC50=37 nM) 和 MAO-B (IC50=57 nM) 抑制剂。
GC50320 Calcitonin (human)
降钙素,人
A peptide hormone that lowers blood calcium levels
GC50306 CMPI hydrochloride Potent positive allosteric modulator of α4β2 nAChRs; also inhibitor of (α4)2(β2)3, muscle-type and Torpedo nAChRs
GC50305 Autocamtide-2-related inhibitory peptide, myristoylated Autocamtide-2 相关抑制肽，肉豆蔻酰化是肉豆蔻酰化 Autocamtide-2 相关抑制肽。
GC50260 HS 38 HS 38 是一种有效的、选择性的和 ATP 竞争性的死亡相关蛋白激酶 1 (DAPK1) 和拉链相互作用蛋白激酶 (ZIPK，也称为 DAPK3) 抑制剂，Kd 值分别为 300 nM 和 280 nM。
GC50258 (R)-Citalopram oxalate
(R)-草酸西酞普兰
Enantiomer of escitalopram oxalate
GC50213 WAY 181187 oxalate
SAX-187 oxalate
WAY-181187 (SAX-187) oxalate 是一种有效的选择性全 5-HT6 受体激动剂，Ki 为 2.2 nM，EC50 为 6.6 nM。
GC50202 SSR 180711 hydrochloride SSR 180711 hydrochloride 是一种具有口服活性、选择性和可逆的 α7 乙酰胆碱烟碱受体 (n-AChRs) 部分激动剂。
GC50199 Ropinirole - d7
4-[2-[丙基(丙基-1,1,2,2,3,3,3-D7)氨基]乙基]-1,3-二氢-2H-吲哚-2-酮盐酸盐
An internal standard for the quantification of ropinirole
GC50198 Topiramate - d12
托吡酯-D12,McN 4853 D12 ; RWJ 17021 D12
An internal standard for the quantification of topiramate
GC50195 Citalopram - d4 hydrobromide
Bonitrile-d4, Nitalapram-d4, Prepram-d4
An internal standard for the quantification of citalopram
GC50193 Clozapine - d8
HF 1854-d8
Clozapine - d8 (HF 1854-d8) 是氘标记的氯氮平。
GC50192 Tomoxetine - d3 hydrochloride
盐酸阿托西汀-d3
An internal standard for the quantification of atomoxetine
GC50191 Fluoxetine - d5 hydrochloride
氘代盐酸氟西汀,LY 110140-d5
An internal standard for the quantification of fluoxetine
GC50126 CC4
野决明定
High affinity and subtype-selective α6β2 and α4β2 nAChR partial agonist
GC50088 A 85380 dihydrochloride High affinity and selective α4β2 nAChR agonist
GC50084 Eplivanserin hemifumarate
富马酸依利色林,SR-46349 hemifumarate; SR 46349B
Eplivanserin (SR-46349) hemifumarate 是一种有效、选择性和口服活性的 5-HT2A 受体拮抗剂，在大鼠皮质膜中的 IC50 为 5.8 nM，Kd 为 1.14 nM。
GC50079 NS3861 fumarate
NS3861 fumarate 是烟碱型乙酰胆碱受体 (nAChRs) 的激动剂，并以高亲和力与异聚体 α3β4 nAChR 结合。
GC50069 GR 203040 Potent and selective NK1 antagonist
GC50042 CP 122721 hydrochloride High affinity NK1 antagonist
GC50033 RS 127445 hydrochloride
4-(4-氟-1-萘基)-6-(1-甲基乙基)-2-嘧啶胺盐酸盐
A 5-HT_2B receptor antagonist
GC50031 Tandospirone hydrochloride
SM-3997 hydrochloride
Tandospirone (SM-3997) hydrochloride 是一种有效的选择性 5-HT1A 受体部分激动剂，Ki 为 27 nM。
GC50027 Xaliproden hydrochloride
盐酸扎利罗登,SR57746A; SR57746 hydrochloride
A 5-HT_1A receptor agonist
GC50018 Fenoldopam hydrochloride Selective D1-like partial agonist
GC50014 SB 215505
6-氯-2,3-二氢-5-甲基-N-5-喹啉基-1H-吲哚-1-甲酰胺
SB 215505 是一种有效的亚型选择性 5-HT2B 受体拮抗剂，对 5-HT2B、5-HT2A、5-HT2C 的 pKi 值分别为 8.3、6.77、7.66。
GC50007 RS 102221 hydrochloride A 5-HT_2C receptor antagonist
GC50006 RU 24969 hemisuccinate
5-甲氧基-3-(1,2,3,6-四氢-4-吡啶基)-1H-吲哚半琥珀酸盐
A 5-HT_1A and 5-HT_1B receptor agonist
GC39307 4-Methylamino antipyrine
4-(甲氨基)安替比林
An active metabolite of metamizole
GC39293 ICA-27243 ICA-27243, a selective activator of the neuronal M current and KCNQ2/Q3 channels, induces a concentration-dependent increase in a 86Rb+ efflux from CHO cells expressing KCNQ2/Q3 channels with EC50 of 0.2 μM.
GC39277 Nemifitide diTFA
INN 00835 diTFA
Nemifitide diTFA (INN 00835 diTFA) 是一种合成的五肽抗抑郁药，具有迅速起效的潜力。Nemifitide diTFA 是黑色素细胞抑制因子 (MIF) 的肽类似物。Nemifitide diTFA 可以透过血脑屏障。
GC39256 LP-935509 LP-935509 是一种小分子衔接蛋白-2 相关激酶1 (AAK1) 选择性和脑渗透抑制剂 (IC50=3.3 nM)，一种 ATP 竞争性抑制剂，其 Ki 为 0.9 nM。 LP-935509 是 BIKE 的有效抑制剂 (IC50=14 nM) 和适度的 GAK 抑制剂 (IC50=320 nM)。 LP-935509 可逆转 SNL 手术后的疼痛。
GC39254 Anatabine dicitrate
柠檬酸新烟草碱
Anatabine dicitrate 是一种烟草生物碱，可以穿过血脑屏障。Anatabine dicitrate 是一种有效的 α4β2 nAChR 激动剂。Anatabine dicitrate 通过阻止淀粉样蛋白前体蛋白的 β 裂解，抑制 NF-κB 激活，并降低淀粉样 β (Aβ) 的产生。Anatabine dicitrate 具有抗炎作用，可用于神经退行性疾病的研究。
GC39248 Afoxolaner
阿福拉纳
An isoxazoline insecticide and acaricide
GC39237 Perospirone
哌罗匹隆; SM-9018 free base
Perospirone (SM-9018 free base) is an orally active antagonist of 5-hydroxytryptamine2 (5-HT2) receptor, dopamine2 (D2) receptor and 5-HT1A receptor with Ki of 0.6 nM, 1.4 nM and 2.9 nM, respectively.
GC46221 Seselin
邪蒿素
An angular pyranocoumarin with diverse biological activities
GC46213 Ro 41-0960 A COMT inhibitor
GC46208 Propentofylline
普罗潘非林,HWA 285
A xanthine derivative and neuroprotective agent
GC46206 Picamilon
匹卡米隆,Nicotinoyl-GABA; Nicotinoyl-γ-aminobutyric acid
A GABA derivative
GC46202 Phenoxybenzamine-d5 (hydrochloride)
盐酸酚苄明 d5 (盐酸盐)
An internal standard for the quantification of phenoxybenzamine