Picamilon is a derivative of γ-aminobutyric acid (GABA).1 It increases parietal cortical blood flow in rats and rabbits when administered at doses of 50 mg/kg, i.p. and 10 mg/kg, i.v., respectively.2 Picamilon (10 mg/kg) increases latency to enter the dark compartment in the passive avoidance conditioned reflex test in rats compared with control animals, indicating nootropic effects.1
|1. Kopelevich, V.M., Bulanova, L.N., Grigor'ev, I.A., et al. Synthesis and study of psychotropic and hypotensive properties of new picamilon derivatives. Pharm. Chem. J. 31(10), 536-539 (1997).|2. Mirzoyan, R.S., Gan'shina, T.S., Kosoi, M.Y., et al. Effect of picamilon on the cerebral cortical blood supply and microcirculation in the pial arteriolar system. Biull. Eksp. Biol. Med. 107(5), 668-670 (1989).